今天是:2017年11月19日 星期日 农历十月初二
兰轲 副教授(硕士生导师)
作者:佚名  来源:  发布时间:2016年02月06日  点击/评论:7507/0

四川大学华西药学院

通讯地址成都市人民南路三段17

电话/传真028-85503722

电子邮件lanwoco@scu.edu.cn

简历

1996~2001年,四川大学华西药学院,临床药学专业本科

2001~2004年,四川大学华西药学院,药剂学专业硕士研究生

2004~2007年,四川大学华西药学院,药剂学专业博士研究生

2007~2011年,四川大学华西药学院,讲师

2011~,四川大学华西药学院,副教授

研究方向与兴趣

1. 天然药物药代动力学研究:1). 探索具有重要生理活性的复杂结构天然药物的生物转化过程;1). 探索化学组成复杂的天然药物药代动力学研究的代谢组学技术方法。

2. 天然药物口服固体制剂的体内外相关性研究:1). 发展适用于化学组成复杂的天然药物的溶出度评价与调控方法;2). 探讨天然药物口服固体制剂中活性成分的溶出与体内药动学过程的相关性。

代表论著

1.        Ke Lan, Guoxiang Xie, Wei Jia*. Towards polypharmacokinetics: pharmacokinetics of multi-component drugs and herbal medicines using a metabolomics approach. EVID BASED COMPLEMENT ALTERNAT MED. 2013, 819147.

2.        Zhanguo Wang, Huiling Hu, Fang Chen*, Ke.Lan, Anqi Wang. Reduced system exposures of total rhein and baicalin after combinatory oral administration of rhein, baicalin and berberine to beagle dogs and rats. J ETHNOPHARMACOL. 2013, 145(2): 442-449.

3.        Anqi Wang, Zhanguo Wang, WenJun Yu, Ting Zhong, Yang Daiwei, Liang Xu, Tao Gong, Ke Lan*. Self-Reference chemical profiling in the comprehensive dissolution test of herbal medicines. J PHARMACEUT BIOMED, 2012, 70: 117-125.

4.        Guoxiang Xie, Aihua Zhao, Linjing Zhao, Tianlu Chen, Huiyaun Chen, Xin Qi, Xiaojiao Zheng, Yan Ni, Yu Cheng, Chun Yao, Ke Lan, Mingfeng Qiu, Wei Jia*. Metabolic fate of tea polyphenols in humans. J PROTEOME RES, 2012, 11(6): 3449?3457.

5.        Zhanguo Wang, Huiling Hu, Fang Chen*, Liang Zou, Mingfu Yang, Anqi Wang, Ke Lan*. Metabolic profiling assisted quality assessment of Rhodiola rosea extracts by high performance liquid chromatography. PLANTA MED, 2012, 78(7):740-746.

6.         An-Qi Wang, Bo-Ping Wei, Yan Zhang, Yu-Jun Wang, Liang Xu, Ke Lan*. An ultra-high sensitive bioanalytical method for plasma melatonin by liquid chromatography–tandem mass spectrometry using water as calibration matrix. J CHROMATOGR B, 2011, 879(23): 2259-2264.

7.         Ke Lan*, Wei Jia*. An integrated metabolomics and pharmacokinetics strategy for multi-component drugs evaluation. CURR DRUG METAB, 2010, 11(1): 105-114.

8.         Ke Lan*, Yang Zhang, Junyi Yang and Liang Xu. Simple quality assessment approach for herbal extracts using high performance liquid chromatography-UV based metabolomics platform. J CHROMATOGR A, 2010, 1217 (8): 1414–1418.

9.         Li Chen, Xuehua Jiang, Liang Huang, Ke Lan*, Haiying Wang, Lina Hu, Jing Ren, Xihong Li, Qin Zou. Bioequivalence of a single 10-mg dose of finasteride 5-mg oral disintegrating tablets and branded tablets in healthy adult male Chinese Han volunteers: a randomized sequence, open-label, two-period crossover study. CLIN THER, 2009, 31(10):2242-2248.

10.     Zhanguo Wang, Qingqing Du, Xuelan Qiu, Fang Liu, Fei Tan, Ke Lan*, Xuehua Jiang and Qian Jiang. Simultaneous determination of six herbal components in intestinal perfusate by high-performance liquid chromatography. BIOMED CHROMATOGR. 2009, 23 (8): 798-803.

11.     Ke Lan, Jian-lin He, Yang Tian, Fei Tan, Xue-hua Jiang*, Ling Wang, Li-ming Ye. Intra-herb pharmacokinetics interaction between quercetin and isorhamentin. ACTA PHARMACOL SIN. 2008, 29 (11): 1376-1382.

12.     Ke Lan, Xuehua Jiang*, Yunxia Li, Ling Wang, Jing Zhou, Qian Jiang, Limin Ye. Quantitative determination of rosuvastatin in human plasma by ion pair liquid-liquid extraction using liquid chromatography with electrospray ionization tandem mass spectrometry. J PHARMACEUT BIOMED, 2007, 44(2): 540-546.

13.     Ke Lan, Xuehua Jiang*, Jianling He. Quantitative determination of isorhamnetin, quercetin and kaempferol in rat plasma by liquid chromatography with electrospray ionization tandem mass spectrometry and its application to the pharmacokinetic study of isorhamnetin. RAPID COMMUN MASS SP, 2007, 21 (2): 112-120.




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