今天是:2017年8月19日 星期六 农历六月廿八
高会乐 副教授(硕士生导师)
作者:佚名  来源:  发布时间:2016年02月07日  点击/评论:11917/0
 

单位:四川大学华西药学院药剂学系

通讯地址:成都市人民南路三段17号四川大学华西药学院药学大楼609

E-mail:gaohuile@scu.edu.cn

 

简历

2004.09-2008.07复旦大学药学院,获理学学士学位

2008.09-2013.06 复旦大学药学院,获药剂学博士学位

2013.07-2014.06四川大学华西药学院药剂系讲师

2014.07至今    四川大学华西药学院药剂系副教授、硕导

2015.10-2016.10 斯坦福大学医学院访问学者

 

 

研究方向

1、新型脑靶向递药系统的构建和评价;

2、基于荧光碳量子点的纳米递药系统的设计、表征及应用;

3、具有环境敏感性的纳米递药系统及其材料的设计、合成和评价。

 

主要承担课题

1、    国家自然科学基金面上项目,“基于生物点击化学的肿瘤微环境响应性纳米载体的肿瘤靶向递药研究”,31571016,实施年限:2016.01.01-2019.12.31主持

2、    国家自然科学基金青年项目,“基于粒径智能调节、具有肿瘤微环境响应的脑转移瘤靶向递药系统研究”,81402866,实施年限:2015.01.01-2017.12.31主持

3、    四川大学优秀青年基金项目,“基于生物点击化学的肿瘤微环境响应性纳米载体的肿瘤靶向递药研究”,2015SCU04A14,实施年限:2015.1-2017.12主持

4、    四川大学-泸州市人民政府战略合作科技项目,“(川大-泸州)替莫唑胺胶囊的研制与研发”,2013CDLZ-S14,实施年限2014.01.01-2015.12.31主持。

5、    四川大学青年教师科研启动基金,“靶向分子对纳米系统与血浆蛋白相互作用及靶向性的影响”,2014SCU11044,实施年限:2014.01.01-2015.12.31主持。

 

获得荣誉及学术任职:

1、    201611月起担任《Journal of Microencapsulation》编委

2、    201609月主编专著《Neurotoxicity of Nanomaterials and Nanomedicine》,Elsevier出版社

3、    201608月担任《Current Drug Metabolism》客座主编,主编2016年第8

4、    201511月至今担任《药学学报》青年编委

5、    201508月至今担任《中国医院药学杂志》通讯编委

6、    201510月获中国药学会中恒青年药剂学奖

7、    201504月博士论文获上海市优秀博士论文

8、    201412月获四川大学青年骨干教师称号

 

研究论文:

48. Ruan Shaobo, Hu Chuan, Tang Xian, Cun Xingli, Xiao Wei, Shi Kairong, He Qin, Gao Huile*. Increased gold nanoparticle retention in brain tumors by in situ enzyme-induced aggregation. ACS Nano, 2016. (IF=13.334)

47. Cun Xingli, Ruan Shaobo, Chen Jiantao, Zhang Li, Li Jianping, He Qin*, Gao Huile*. A dual strategy to improve the penetration and treatment of breast cancer by combining shrinking nanoparticles with collagen depletion by losartan. Acta Biomater, 2016, 31C: 186-196. (IF=6.008)

46. Hu Guanlian#, Cun Xingli#, Ruan Shaobo, Shi Kairong, Wang Yang, Kuang Qifang, Hu Chuan, Xiao Wei, He Qin, Gao Huile*. Utilizing G2/M retention effect to enhance tumor accumulation of active targeting nanoparticles. Sci Rep, 2016, 6:27669. (IF=5.228)

45. Hu Chuan#, Liu Yongmei#, Chen Jiantao, He Qin, Gao Huile*. A simple one-step synthesis of melanin-originated red shift emissive carbonaceous dots for bioimaging. J Colloid Interf Sci, 2016, 480: 85-90. (IF=3.782)

 

 

2015

44. Zheng Min, Ruan Shaobo, Liu Shi, Sun Tingting, Qu Dan, Zhao Haifeng, Xie Zhigang*, Gao Huile*, Jing Xiabin, Sun Zaicheng*. Self-targeting fluorescent carbon dots for diagnosis of brain cancer cells. ACS Nano, 2015, 9 (11): 11455–11461. (IF=13.334)

43. Ruan Shaobo, Cao Xi, Cun Xingli, Hu Guanlian, Zhou Yi, Zhang Yanling, Lu Libao, He Qin, Gao Huile*. Matrix metalloproteinase-sensitive size-shrinkable nanoparticles for deep tumor penetration and pH triggered doxorubicin release. Biomaterials, 2015, 60: 100-110. (IF=8.387)

42. Ruan Shaobo, Yuan Mingqing, Zhang Li, Hu Guanlian, Chen Jiantao, Cun Xingli, Zhang Qianyu, Yang Yuting, He Qin*, Gao Huile*. Tumor microenvironment sensitive doxorubicin delivery and release to glioma using angiopep-2 decorated gold nanoparticles. Biomaterials, 2015, 37:425-435. (IF=8.387)

41. Ruan Shaobo, He Qin, Gao Huile*. Matrix metalloproteinase triggered size-shrinkable gelatin-gold fabricated nanoparticles for tumor microenvironment sensitive penetration and diagnosis of glioma. Nanoscale, 2015, 7(21): 9487-9496. (IF=7.76)

40. Cun Xingli, Chen Jiantao, Ruan Shaobo, Zhang Li, Wan Jingyu, He Qin, Gao Huile*. A novel strategy through combining iRGD peptide with tumor microenvironment responsive and multistage nanoparticles for deep tumor penetration. ACS Appl Mater Inter, 2015, 7, 27458?27466. (IF=7.145)

39. Hu Guanlian, Chun Xinli, Wang Yang, He Qin, Gao Huile*. Peptide mediated active targeting and intelligent particle size reduction-mediated enhanced penetrating of fabricated nanoparticles for triple-negative breast cancer treatment. Oncotarget, 2015, 6(38): 41258-41274. (IF=5.008)

38. Ruan Shaobo, Chen Jiantao, Cun Xingli, Long Yang, Tang Jie, Qian Jun, Shen Shun, Jiang Xinguo, Zhu Jianhua, He Qin*, Gao Huile*. Noninvasive in vivo diagnosis of brain gliomas using RGD-decorated fluorescent carbonaceous nanospheres. J Biomed Nanotech, 2015, 11(12): 2148-2157. (IF=3.929)

37. Gao Huile#, Cao Shijie#, Yang Zhi, Zhang Shuang, Pang Zhiqing, Jiang Xinguo. Preparation, characterization and anti-glioma effects of docetaxel-loaded, lipoprotein-like nanoparticles. J Biomed Nanotech, 2015, 11(12):2137-2147. (IF=3.929)

36. Hu Guanlian, Wang Yang, He Qin*, Gao Huile*. Multistage drug delivery system based on microenvironment-responsive dendrimer-gelatin nanoparticles for deep tumor penetration. RSC Adv, 2015, 5: 85933-85937. (IF=3.289)

35. Ruan Shaobo, Zhang Li, Chen Jiantao, Cao Tingwei, Yang Yuting, Liu Yayuan, He Qin, Gao Fabao*, Gao Huile*. Targeting delivery and deep penetration using multistage nanoparticles for triple-negative breast cancer. RSC Adv, 2015, 5:64303 - 64317. (IF=3.289)

34. Chen Jiantao, Cun Xingli, Ruan Shaobo, Wang Yang, Zhang Yanling, He Qin*, Gao Huile*. Glioma cell targeting doxorubicin delivery and redox-responsive release using angiopep-2 decorated carbonaceous nanodots. RSC Adv, 2015, 5: 57045 - 57049. (IF=3.289)

33. Chen Jiantao, Sun Huaqin, Ruan Shaobo, Wang Yang, Shen Shun, Xu Wenming, He Qin, Gao Huile*. In vitro and in vivo toxicology of bare and PEGylated fluorescent carbonaceous nanodots in mice and zebrafish: the potential relation with autophagy. RSC Adv, 2015, 5: 38547-38557. (IF=3.289)

32. Ruan Shaobo#, Qian Jun#, Shen Shun, Chen Jiantao, Cun Xingli, Zhu Jianhua, Jiang Xinguo, He Qin*, Gao Huile*. Non-invasive imaging of breast cancer using RGDyK functionalized fluorescent carbonaceous nanospheres. RSC Adv, 2015, 5: 25428-25436. (IF=3.289)

31. Hu Guanlian#, Zhang Huiqing#, Zhang Li, Ruan Shaobo, He Qin, Gao Huile*. Integrin-mediated active tumor targeting and tumor microenvironment response dendrimer-gelatin nanoparticles for drug delivery and tumor treatment. Int J Pharm, 2015, 496: 1057-1068. (IF=3.994)

30. Gao Huile*, Zhang Qianyu, Yang Yuting, Jiang Xinguo, He Qin*. Tumor homing cell penetrating peptide decorated nanoparticles used for enhanced tumor targeting delivery and therapy. Int J Pharm, 2015, 478: 240-250. (IF=3.994)

29. Chen Jiantao#, Sun Huaqin#, Wang Weiliang, Xu Wenming, He Qin, Shen Shun, Qian Jun*, Gao Huile*. Polyethylene glycol modification reduces the cardiac toxicity of carbonaceous dots in mice and zebrafish model. Acta Pharmacol Sin, 2015, 36(11): 1349-1355. (IF=3.166)

 

2014

28. Gao Huile, Yang Zhi, Cao Shijie, Xiong Yang, Zhang Shuang, Pang Zhiqing, Jiang Xinguo*. Tumor cells and neovasculature dual targeting delivery for glioblastoma treatment. Biomaterials, 2014, 35(7): 2374-2382. (IF=8.557)

27. Ruan Shaobo#, Qian Jun#, Shen Shun, Zhu Jianhua, Jiang Xinguo, He Qin, Gao Huile*. A simple one-step method to prepare fluorescent carbon dots and their potential application in non-invasive glioma imaging. Nanoscale, 2014, 6(17): 10040-10047. (IF=7.394)

26. Gao Huile, Yang Zhi, Zhang Shuang, Pang Zhiqing, Liu Qingfeng, Jiang Xinguo*. Study of the pharmacology mechanisms of dual targeting drug delivery system with tumor microenvironment assays. Acta Biomateria, 2014, 10(2): 858-867. (IF=6.025)高被引论文

25. Gao Huile, Hu Guanlian, Zhang Qianyu, Zhang Shuang, Jiang Xinguo, He Qin*. Pretreatment with chemotherapeutics for enhanced nanoparticles accumulation in tumor: the potential role of G2 cycle retention effect. Sci Rep, 2014,4: 4492. (IF=5.578)

24. Ruan Shaobo#, Qian Jun#, Shen Shun, Chen Jiantao, Zhu Jianhua, Jiang Xinguo, He Qin*, Yang Wuli*, Gao Huile*. Near-infrared fluorescent carbonaceous nanodots for glioma imaging after angiopep-2 decoration. Bioconjug Chem, 2014, 25: 2252-2259. (IF=4.513)

23. Ruan Shaobo, Wan Jingyu, Fu Yao, Han Ke, Li Xiang, Chen Jiantao, Zhang Qianyu, Shen Shun, He Qin, Gao Huile*. PEGylated fluorescent carbon nanoparticles for noninvasive heart imaging. Bioconjug Chem, 2014,25(6): 1061-1068. (IF=4.513)

22. Gao Huile, Zhang Shuang, Cao Shijie, Yang Zhi, Pang Zhiqing, Jiang Xinguo*. Angiopep-2 and activatable cell penetrating peptide dual-functionalized nanoparticles for systemic glioma targeted delivery. Mol Pharm, 2014, 11(8): 2755-2763. (IF=4.384)

21. Gao Huile, Xiong Yang, Zhang Shuang, Yang Zhi, Cao Shijie, Jiang Xinguo*. RGD and interleukin-13 peptide functionalized nanoparticles for enhanced glioblastoma cells and neovasculature dual targeting delivery and elevated tumor penetration. Mol Pharm, 2014,11(3): 1042-1052. (IF=4.384)

20. Mei Ling, Zhang Qianyu, Yang Yuting, He Qin, Gao Huile*. Angiopep-2 and activatable cell penetrating peptide dual modified nanoparticles for enhanced tumor targeting and penetrating. Int J Pharm, 2014, 474: 95-102. (IF=3.65)

19. Gao Huile, Zhang Shuang, Yang Zhi, Cao Shijie, Jiang Xinguo, Pang Zhiqing*. In vitro and in vivo intracellular distribution and anti-glioblastoma effects of docetaxel-loaded nanoparticles functioned with IL-13 peptide. Int J Pharm, 2014, 466(1-2): 8-17.(IF=3.65)

18. Gao H, Wang Y, Chen C, Chen J, Wei Y, Cao S, Jiang X*. Incorporation of lapatinib into core-shell nanoparticles improves both the solubility and anti-glioma effects of the drug. Int J Pharm, 2014; 461(1-2): 478– 488. (IF=3.65)

17. Qian Jun#, Ruan Shaobo#, Cao Xi, Cun Xingli, Chen Jiantao, Shen Shun, Jiang Xinguo, He Qin, Zhu Jianhua*, Gao Huile*. Fluorescent carbonaceous nanospheres as biological probe for noninvasive brain imaging. J Colloid Interf Sci, 2014, 436: 227-233. (IF=3.368)

16. Qian Jun#, Chen Jiantao#, Ruan Shaobo, Shen Shun, He Qin, Jiang Xinguo, Zhu Jianhua*, Gao Huile*. Preparation and biological evaluation of photoluminescent carbonaceous nanospheres. J Colloid Interf Sci, 2014, 429: 77-82. (IF=3.368)

15. Ruan Shaobo, Zhu Biyue, Zhang Huajin, Chen Jiantao, Shen Shun, Qian Jun, He Qin, Gao Huile*. A simple one-step method for preparation of fluorescent carbon nanospheres and the potential application in cell organelles imaging. J Colloid Interf Sci, 2014,422: 25-29. (IF=3.368)

14. Gao Huile, Yang Zhi, Zhang Shuang, Pang Zhiqing, Jiang Xinguo*. Internalization and subcellular fate of aptamer and peptide dual-functioned nanoparticles. J Drug Target, 2014, 22(5): 450-459. (IF=2.741)

13. Zhang Li, Zhang Shuang, Ruan Shaobo, Zhang Qianyu, He Qin, Gao Huile*. Lapatinib incorporated lipoprotein-like nanoparticles: preparation and breast cancer targeting mechanism. Acta Pharmacol Sin, 2014,35(6): 846-852.(IF=2.912)

 

2013 and before

12. Gao Huile, Yang Zhi, Zhang Shuang, Cao Shijie, Pang Zhiqing, Yang Xiao, Jiang Xinguo*. Glioma-homing peptide with a cell-penetrating effect for targeting delivery with enhanced glioma localization, penetration and suppression of glioma growth. J Control Release, 2013, 172(3):921-928. (IF=7.261)

11. Gao Huile, Cao Shijie, Chen Chen, Cao Shilei, Yang Zhi, Xi Zhangjie, Pan Shuaiqi, Zhang Qizhi, Jiang Xinguo*. Incorporation of lapatinib into lipoprotein-like nanoparticles with enhanced water solubility and anti-breast cancer effect. Nanomedicine (Lond), 2013, 8(9): 1429-1442. (IF=5.824)

10. Gao Huile, Yang Zhi, Zhang Shuang, Cao Shijie, Pang Zhiqing*, Jiang Xinguo*. Ligand modified nanoparticles increases cell uptake, alters endocytosis and elevates glioma distribution and internalization. Sci Rep, 2013, 3: 2534. (IF=5.078)

9. Gao Huile#, Hu Yue#, Xiong Yang, Zhang Shuang, Yang Jiarong, Yu Lian*, Jiang Xinguo*. Glioma targeting and anti-glioma effect of interleukin 13 peptide and RGD peptide dual functionalized nanoparticles. Curr Pharm Biotechnol, 2013, 14: 1118-1126.(IF=2.511)

8. Gao Huile, Chen Chen, Xi Zhangjie, Chen Jun, Zhang Qizhi, Cao Shlei, Jiang Xinguo*. In Vivo Behavior and Safety of Lapatinib-Incorporated Lipid Nanoparticles. Curr Pharm Biotechnol, 2013, 14: 1062-1071.(IF=2.511)

7. Gao Huile#, Qian Jun#, Cao Shijie, Yang Zhi, Pang Zhiqing, Pan Shuaiqi, Fan Li, Xi Zhangjie, Jiang Xinguo, Zhang Qizhi*. Precise glioma targeting of and penetration by aptamer and peptide dual-functioned nanoparticles. Biomaterials, 2012, 33(20):5115-5123.(IF=7.604)高被引论文

6. Gao Huile#, Qian Jun#, Yang Zhi, Pang Zhiqing, Xi Zhangjie, Cao Shijie, Wang Yuchen, Pan Shuaiqi, Zhang Shuang, Wang Wei, Jiang Xinguo, Zhang Qizhi*. Whole-cell SELEX aptamer-functionalised poly(ethyleneglycol)-poly(epsilon-caprolactone) nanoparticles for enhanced targeted glioblastoma therapy. Biomaterials, 2012, 33(26): 6264-6272. (IF=7.604)

5. Gao Huile, Yang Zhi, Cao Shijie, Xi Zhangjie, Zhang Shuang, Pang Zhiqing, Jiang Xinguo*. Behavior and anti-glioma effect of lapatinib-incorporated lipoprotein-like nanoparticles. Nanotechnology, 2012,23(43):435101. (IF=3.842)

4. Gao Huile, Pang Zhiqing, Pan Shuaiqi, Cao Shijie, Yang Zhi, Chen Chen, Jiang Xinguo*. Anti glioma effect and safety of docetaxel-loaded nanoemulsion. Arch Pharm Res, 2012,35(2):333-341. (IF=1.538)

3. Gao Huile, Pan Shuaiqi, Yang Zhi, Cao Shijie, Chen Chen, Jiang Xinguo, Pang Zhiqing*, Hu Yu*. A cascade targeting strategy for brain neuroglial cells employing nanoparticles modified with angiopep-2 peptide and EGFP-EGF1 protein. Biomaterials, 2011, 32(33): 8669-8675. (IF=7.404)

2. Gao Huile, Pang Zhiqing, Lu Wei, Pan Shuaiqi, Jiang Xinguo*. Encapsulation of cationic peptides into polymersomes through in situ gelatinization. J Microencapsul, 2011, 28(6): 465-471. (IF=1.553)

1. Gao Huile, Pang Zhiqing, Fan Li, Hu Kaili, Wu Bingxian, Jiang Xinguo*. Effect of lactoferrin- and transferrin-conjugated polymersomes in brain targeting: in vitro and in vivo evaluations. Acta Pharmacol Sin, 2010,31(2): 237-243. (IF=1.953)

 

综述和书的章节

12. Jiang Xinguo, Gao Huile, Edited. Neurotoxicity of Nanomaterials and Nanomedicine. Elsevier Inc, 2016.9.28, Singapore.

11. Gao Huile*. Editorial (Thematic Issue: Nanoparticles for Brain and Tumor Targeting Delivery). Curr Drug Metab, 2016, 17(8): 730. (IF=2.847)

10. Gao Huile*. Shaping tumor microenvironment for improving nanoparticles delivery. Curr Drug Metab, 2016, 17(8): 731-736. (IF=2.847)

9. Gao Huile*. Progress and perspectives on targeting nanoparticles for brain drug delivery. Acta Pharmaceutica Sinica B, 2016, 6(4): 268-286.

8. Gao Huile*. Perspectives on dual targeting delivery systems for brain tumors. Journal of Neuroimmune Pharmacology, 2016, 1-11, DOI: 10.1007/s11481-016-9687-4. (IF=3.896)

7. Gao Huile, Jiang Xinguo*. The development of novel tumor targeting delivery strategy. Acta Pharmaceutica Sinica, 2016, 51(2): 272-280.

6. Gao Huile. Nanoparticles for brain targeting drug delivery. In Hari Singh Nalwa, Encyclopedia of nanoscience and nanotechnology, American Scientific Publishers, 2016, Valencia, chapter 9, 1-21.

5. Gao Huile, Jiang Xinguo. Brain delivery using nanotechnology. In Di Li and Edward H. Kerns. Blood-Brain Barrier in Drug Discovery: Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects, John Wiley & Sons, Inc, 2015, New York, chapter 24, 521-534.

4. Gao Huile, Zhang Qianyu, Yu Zhiqiang, He Qin*. Cell-penetrating peptide-based intelligent liposomal systems for enhanced drug delivery. Curr Pharm Biotechnol, 2014, 15(3):210-219. (IF=2.511)

3. Gao Huile, He Qin*. The interaction of nanoparticles with plasma proteins and the consequent influence on nanoparticles behavior. Expert Opin Drug Deliv, 2014,11(3): 409-420. (IF=4.84)

2. Gao Huile, Jiang Xinguo*. Progress on the diagnosis and evaluation of brain tumors. Cancer Imaging, 2013, 13(4): 466-481. (IF=1.592)

1. Gao Huile, Pang Zhiqing, Jiang Xinguo*. Targeted delivery of nano-therapeutics for major disorders of the central nervous system. Pharm Res, 2013, 30: 2485-2498. (IF=3.952)

 



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