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孙逊 教授 (博士生导师)
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孙逊教授 (博士,博士生导师)

单位:四川大学华西药学院药剂教研室

通讯地址:成都市人民南路三段17号四川大学华西药学院

电话/传真:(02885502307

E-mail: sunxun@scu.edu.cnxunsun22@gmail.

简历

现任四川大学华西药学院教授,博士生导师,国家优秀青年科学基金获得者,国家药典委员会委员,教育部新世纪优秀人才,四川省高级留学回国人员。

1991.9-1996.7  华西医科大学药学院本科

1996.8-2000.7  第一军医大学珠江医院

2000.9-2005.7  四川大学华西药学院攻读药剂学博士学位

2005.8-2007.2  美国宾夕法尼亚大学医学院博士后

2   2007.2-2008.9  美国密西根大学药学院博士后

2008.9-2012.6  四川大学华西药学院副研究员

2012.7-      四川大学华西药学院教授

 

 

 

 

 

 

 

研究方向

1.   生物技术药物递释系统。

2.   靶向药物传递系统和分子药剂学。

 

学术兼职

国家药典委员会委员(生物制品专业),四川省药学会副秘书长和常务理事,四川省药学会生物药物专业副主任委员。药剂学顶级SCI期刊《J. Controlled Release》编委;药学学报英文刊《Acta Pharmaceutica Sinica B》编委;《中国工业医药杂志》编委;《中国生化药物杂志》编委。担任捷克科学基金会项目评审专家;担任国家自然科学基金委医学部优青项目二审专家和科技部“重大新药创制”的评审专家。          

 

科研成果获奖情况:

1)   2015年荣获四川省科技进步一等奖 (第5完成人);获奖题目:中药新型给药系统的示范研究与应用

2)   2015年荣获第三届四川省卫计委有突出贡献的中青年专家荣誉称号

3)   2014年荣获成都市科学技术进步奖二等奖;获奖题目:中药新型给药系统的示范研究与应用(第5完成人)

4)   2012年获“中国药学会青年药剂奖”

5)   2011年荣获第十一届四川省青年科技奖

6)   2011年荣获四川省科技进步一等奖 (第3完成人);获奖题目:针对多种器官组织或细胞的靶向释药系统的构建、表征及靶向特性研究

7)   2008年获全国百篇优秀博士学位论文提名奖,获奖题目:静脉注射用治疗基因靶向传递系统研究

8)   2006年荣获四川省科技进步三等奖(第2完成人);获奖题目:治疗基因靶向传递系统的研究

 

主持的科研项目:

主持国家自然科学基金课题

1)   克服免疫抑制屏障的多功能肿瘤疫苗载体的构建及其机制研究,816733622017.1-2020.12, 在研。

2)   国家自然科学基金委优秀青年科学基金,814220442015.1-2017.12, 在研。

3)   跨越肿瘤递送屏障的多功能腺病毒载体系统的研究,811730112012.-2015,已结题。

4)   基于载体构-效关系设计的多功能高效肺靶向siRNA传递系统研究309736572010 -2012, 已结题。

5)   呼吸道粘膜上皮细胞靶向基因传递系统的研究,306007862007-2009,已结题。

主持国际合作项目:

6)   yaluronan-based injectable material for tissue engineering,欧盟第七框架项目, PIRSES-GA-2008-230791, 2009-2013,已结题。

7)   Nanomedicines for Drug Delivery Applications of anticancer small molecule, Hgene and protein,与英国中央兰开夏大学合作项目, 11H1554, 2011-2015,已结题。

   主持国家“重大新药创制”科技重大专项子课题

1)   基因传递系统关键技术研究, 2011ZX09401-304(4-3),负责人, 2011-2013,已结题。

主持人才项目:

1)   教育部新世纪优秀人才支持计划,NCET-10-06012010-2012, 已结题。

2)   四川省杰出青年学术技术带头人培育计划,2012JQ00242012-2014,已结题。

3)   四川大学优秀青年学者基金,2011SCU04B362011-2013,已结题。

 

 

Prof. Dr. Xun Sun

Key Laboratory of Drug-Targeting and Drug Delivery System, Ministry of Education
Department of Pharmaceutics
West China School of Pharmacy
Sichuan University, Chengdu 610041, China
Tel/Fax: (+86) 28 85502307
E-mail:
sunxun@scu.edu.cn
xunsun22@gmail.com

 

l  Prof. Xun Sun received her B.S. degree from West China University of Medical Sciences in 1996 and PhD in Pharmaceutics from Sichuan University (Chengdu, China) in 2005. From 1996 to 2000 Dr. Xun Sun was a clinical pharmacist in Zhujiang Hospital (Guangzhou, China). Since Sept 2005, she was a postdoctoral researcher mentored by Dr. James Wilson in The University of Pennsylvania (USA). From Feb. 2007 to Sept 2008, Dr. Xun Sun was working in the college of Pharmacy at The University of Michigan (USA). From Sept 2008 till now, she is a faculty member at Sichuan University. She has also been appointed as a Visiting Fellow by the University of Central Lancashire (UK). Prof. Sun’s current research centers on the targeted drug delivery systems and the delivery of biopharmaceuticals. She has strong expertise on pharmaceutical formulation using micro- and nano-particulate drug delivery systems for the delivery of macromolecules such as proteins, genes and vaccines. Prof. Sun has authored or co-authored more than 90 peer-reviewed papers and contributed chapters to 3 books. Dr. Sun was honored with the Nagai Foundation Tokyo international scholarship in 2005. She received the first and third Prize of Sichuan Provincial Science and Technology Improvement Prize in 2011 and 2006. She serves as the editorial board member of J. Controlled Release and the member of Chinese Pharmacopoeia Commission.

Selected Publications (代表性论著)

More publication can be found in https://orcid.org/0000-0002-0218-1664 

1.       Hanmei Li, Yao Fu, Ting Zhang, Yanping Li, Xiaoyu Hong, Jiayu Jiang, Tao Gong, Zhirong Zhang, Xun Sun*, Rational Design of Polymeric Hybrid Micelles with Highly Tunable Properties to Co-Deliver MicroRNA-34a and Vismodegib for Melanoma Therapy, Adv. Funct. Mater. IF=11.382, 2015, 25, 7457–7469

2.       Lu Han, Jiao Xue, Luyao Wang, Ke Peng, Zhirong Zhang, Tao Gong, Xun Sun*,  An injectable, low-toxicity phospholipid-based phase separation gel that induces strong and persistent immune responses in miceBiomaterials. IF= 8.387,2016;105,185-194

3.       Qin Wang, Jiayu Jiang, Wenfei Chen, Hao Jiang, Zhirong Zhang, Xun Sun*, Targeted delivery of low-dose dexamethasone using PCL–PEG micelles for effective treatment of rheumatoid arthritis Journal of Controlled Release, IF=7.786, 2016, 23064–72

4.       Man Li,  Mengnan ZhaoYao FuYou Li, Tao Gong, Zhirong Zhang, Xun Sun*, Enhanced intranasal delivery of mRNA vaccine by overcoming the nasal epithelial barrier via intra- and paracellular pathwaysJournal of Controlled Release, IF=7.786, 2016, 2289–19

5.       Gerui Fan, Minmin Fan, Qin Wang, Jiayu Jiang, Yu Wan, Tao Gong, Zhirong Zhang, Xun Sun*Bio-inspired polymer envelopes around adenoviral vectors to reduce immunogenicity and improve in vivo kineticsActa Biomaterialia  IF=6.008, 201630 94–105

6.       Zhonghua Ji, Zhaolu Xie, Zhirong Zhang, Tao Gong, Xun Sun*Engineering intravaginal vaccines to overcome mucosal and epithelial barriersBiomaterials. IF= 8.387,2017;128,8-18

7.       Qin Zeng, Hanmei Li, Hao Jiang, Jiao Yu, Ying Wang, Huan Ke, Tao Gong, Zhirong Zhang, Xun Sun*, Tailoring polymeric hybrid micelles with lymph node targeting ability to improve the potency of cancer vaccines, Biomaterials. IF= 8.387,2017;122,105-113

8.       Qin Wang, Hao Jiang, Yan Li, Wenfei Chen, Hanmei Li, Ke Peng, Zhirong Zhang, Xun Sun*, Targeting NF-kB Signaling With Polymeric Hybrid Micelles That Co-Deliver siRNA and Dexamethasone for Arthritis Therapy, Biomaterials. IF= 8.387,2017;122,10-22

9.       Chunhong Li, Hanmei Li, QinWang, Meiling Zhou, Man Li, Tao Gong, Zhirong Zhang, Xun Sun*, pH-sensitive polymeric micelles for targeted delivery to inflamed joints, Journal of Controlled Release, IF=7.786, 2017, 246,133–141

10.    Qin Zeng, Hao Jiang, Ting Wang, Zhirong Zhang, Tao Gong, Xun Sun*, Cationic micelle delivery of Trp2 peptide for efficient lymphatic draining and enhanced cytotoxic T-lymphocyte responses, Journal of Controlled Release, IF=7.261, 2015,200:1-12

11.    Sanjun Shi, Lu Han, Li Deng, Yanling Zhang, Hongxin Shen, Tao Gong, Zhirong Zhang, Xun Sun*, Dual drugs (microRNA-34a and paclitaxel)-loaded functional solid lipid nanoparticles for synergistic cancer cell suppression, Journal of Controlled Release, IF=7.261, 2014,194:228-237.

12.    Zhaolu Xie, Zhonghua Ji, Zhirong Zhang, Tao Gong, Xun Sun*, Adenoviral vectors coated with cationic PEG derivatives for intravaginal vaccination against HIV-1, Biomaterials. IF= 8.312, 2014;35,7896-7908

13.    Jianfeng  Han , Qin  Wang , Zhirong  Zhang , Tao  Gong ,  Xun  Sun*, Cationic Bovine Serum Albumin Based Self-Assembled Nanoparticles as siRNA Delivery Vector for Treating Lung Metastatic Cancer. Small, IF=7.514, 2014, 10: 3524–3535

14.    Sanjun Shi, Lu Han, Tao Gong, Zhirong Zhang, Xun Sun*, Systemic delivery of microRNA-34a for cancer stem cell therapy. Angewandte Chemie International Edition, IF=11.336, 2013,52:3901-3905.

15.    Yu Wan, Jianfeng Han, Gerui Fan, Zhirong Zhang, Tao Gong, Xun Sun* Enzyme-responsive liposomes modified adenoviral vectors for enhanced tumor cell transduction and reduced immunogenicity Biomaterials. IF= 8.312, 2013;34,3020-3030

16.    Yan Lin, Yanping Li, Xiaohong Wang, Tao Gong, Ling Zhang*, Xun Sun*.  Targeted drug delivery to renal proximal tubule epithelial cells mediated by 2-glucosamine. Journal of Controlled Release, IF= 7.633, 2013,167:148–156

17.    Qiang Peng, Zhi-Rong Zhang, Tao Gong, Guo-Qiang Chen,* Xun Sun,*A rapid-acting, long-acting insulin formulation based on a phospholipid complex loaded PHBHHx nanoparticles Biomaterials. IF= 7.404,2012;33,1583-1588

18.    Hanmei Li, Hao Jiang, Mengnan Zhao, Yao Fu and Xun Sun*, Intracellular redox potential-responsive micelles based on polyethylenimine-cystaminepoly ( ε -caprolactone) block copolymer for enhanced miR-34a delivery, Polymer Chemistry, IF=5.368, 2015, 6, 1952–1960

19.    Hanmei Li, Xun Sun*, Dong Zhao, Zhirong Zhang. A cell-specific Poly(ethylene glycol) Derivative with a wheat-like structure for efficient gene delivery. Molecular pharmaceutics. IF= 4.782,2012;9, 2974-2985.

20.    SanJun Shi , ZhiRong Zhong , Jie Liu , ZhiRong Zhang, Xun Sun*, Tao Gong*. Solid Lipid Nanoparticles Loaded with Anti-microRNA Oligonucleotides (AMOs) for Suppression of MicroRNA-21 Functions in Human Lung Cancer Cells. Pharmaceutical Research. IF= 4.093, 2012;29:97-109

 



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