今天是:2017年6月23日 星期五 农历五月廿九
孙逊 教授 (博士生导师)
作者:佚名  来源:  发布时间:2016年02月09日  点击/评论:27136/0

单位:四川大学华西药学院药剂教研室
 通讯地址:成都市人民南路三段17号四川大学华西药学院
 电话/传真:(028)85502307
 E-mail:
sunxun@scu.edu.cnxunsun22@gmail.com

 

简历
现任四川大学华西药学院教授,博士生导师,国家优秀青年科学基金获得者,教育部新世纪优秀人才,四川省高级留学回国人员,四川省药学会副秘书长,四川省学术和技术带头人后备人选,兼任英国中央兰开夏大学访问研究员(Visiting Fellow)。
1991.9-1996.7  华西医科大学药学院本科
1996.8-2000.7  第一军医大学珠江医院
2000.9-2005.7  四川大学华西药学院攻读药剂学博士学位
2005.8-2007.2  美国宾夕法尼亚大学医学院博士后
2007.2-2008.9  美国密西根大学药学院博士后
2008.9-今      四川大学华西药学院教师

研究方向
1.药物及治疗基因传递系统。
2.分子药剂学: 从分子水平研究载体、药物,机体的相互作用。
科研成果获奖情况:
1)“静脉注射用治疗基因靶向传递系统研究”,2008年获全国百篇优秀博士学位论文提名奖
2)2012年获“中国药学会-石药青年药剂奖”
3)2011年荣获第十一届四川省青年科技奖
4)“针对多种器官组织或细胞的靶向释药系统的构建、表征及靶向特性研究” 2011年荣获四川省科技进步一等奖 (第3完成人)
5)“治疗基因靶向传递系统的研究”2006年荣获四川省科技进步三等奖(第2完成人)

主持的科研项目:
主持国家自然科学基金课题:
1)国家自然科学基金委优秀青年科学基金,81422044,2015.1-2017.12, 在研。
2)跨越肿瘤递送屏障的多功能腺病毒载体系统的研究,81173011,2012.-2015,在研。
3)基于载体构-效关系设计的多功能高效肺靶向siRNA传递系统研究30973657,2010 -2012, 已结题。
4)呼吸道粘膜上皮细胞靶向基因传递系统的研究,30600786,2007-2009,已结题。
主持国际合作项目:
1)Hyaluronan-based injectable material for tissue engineering,欧盟第七框架项目, PIRSES-GA-2008-230791, 2009-2013,已结题。
2)Nanomedicines for Drug Delivery Applications of anticancer small molecule, gene and protein,与英国中央兰开夏大学合作项目, 11H1554, 2011-2015,在研。
主持国家“重大新药创制”科技重大专项子课题:
1)基因传递系统关键技术研究, 2011ZX09401-304(4-3),负责人, 2011-2013,已结题。

主持人才项目:
1)教育部新世纪优秀人才支持计划,NCET-10-0601,2010-2012, 已结题。
2)四川省杰出青年学术技术带头人培育计划,2012JQ0024,2012-2014,已结题。
3)四川大学优秀青年学者基金,2011SCU04B36,2011-2013,已结题。

 

Prof. Dr. Xun Sun
Key Laboratory of Drug-Targeting and Drug Delivery System, Ministry of Education
Department of Pharmaceutics
West China School of Pharmacy
Sichuan University, Chengdu 610041, China
Tel/Fax: (+86) 28 85502307
E-mail:
sunxun@scu.edu.cnxunsun22@gmail.com

? Prof. Xun Sun received her B.S. degree from West China University of Medical Sciences in 1996 and PhD in Pharmaceutics from Sichuan University (Chengdu, China) in 2005. From 1996 to 2000 Dr. Xun Sun was a clinical pharmacist in Zhujiang Hospital (Guangzhou, China). Since Sept 2005, she was a postdoctoral researcher mentored by Dr. James Wilson in The University of Pennsylvania (USA). From Feb. 2007 to Sept 2008, Dr. Xun Sun was working in the college of Pharmacy at The University of Michigan (USA). From Sept 2008 till now, she is a faculty member at Sichuan University. She has also been appointed as a Visiting Fellow by the University of Central Lancashire (UK). Prof. Sun’s current research centers on the targeted drug delivery systems and the delivery of biopharmaceuticals. She is also interested in enhancing the potency of viral vectors by pharmaceutical technologies for their application in gene therapy and genetic vaccine. Prof.  Sun has authored or co-authored more than 50 peer-reviewed papers and contributed chapters to 2 books. Dr. Sun was honored with the Nagai Foundation Tokyo international scholarship in 2005. She received the first and third Prize of Sichuan Provincial Science and Technology Improvement Prize in 2011 and 2006. She also received the nomination award of China Top 100 Excellent Doctoral Dissertations in 2008 and Sichuan youth award for science and technology in 2011.

Selected Publications (代表性论著)
1.Qin Zeng, Hao Jiang, Ting Wang, Zhirong Zhang, Tao Gong, Xun Sun*, Cationic micelle delivery of Trp2 peptide for efficient lymphatic draining and enhanced cytotoxic T-lymphocyte responses, Journal of Controlled Release, IF=7.261, 2015,200:1-12
2.Sanjun Shi, Lu Han, Li Deng, Yanling Zhang, Hongxin Shen, Tao Gong, Zhirong Zhang, Xun Sun*, Dual drugs (microRNA-34a and paclitaxel)-loaded functional solid lipid nanoparticles for synergistic cancer cell suppression, Journal of Controlled Release, IF=7.261, 2014,194:228-237.
3.Zhaolu Xie, Zhonghua Ji, Zhirong Zhang, Tao Gong, Xun Sun*, Adenoviral vectors coated with cationic PEG derivatives for intravaginal vaccination against HIV-1, Biomaterials. IF= 8.312, 2014;35,7896-7908
4.Jianfeng  Han , Qin  Wang , Zhirong  Zhang , Tao  Gong ,  Xun  Sun*, Cationic Bovine Serum Albumin Based Self-Assembled Nanoparticles as siRNA Delivery Vector for Treating Lung Metastatic Cancer. Small, IF=7.514, 2014, 10: 3524–3535
5.Sanjun Shi, Lu Han, Tao Gong, Zhirong Zhang, Xun Sun*, Systemic delivery of microRNA-34a for cancer stem cell therapy. Angewandte Chemie International Edition, IF=11.336, 2013,52:3901-3905.
6.Yu Wan, Jianfeng Han, Gerui Fan, Zhirong Zhang, Tao Gong, Xun Sun* Enzyme-responsive liposomes modified adenoviral vectors for enhanced tumor cell transduction and reduced immunogenicity Biomaterials. IF= 8.312, 2013;34,3020-3030
7.Yan Lin, Yanping Li, Xiaohong Wang, Tao Gong, Ling Zhang*, Xun Sun*.  Targeted drug delivery to renal proximal tubule epithelial cells mediated by 2-glucosamine. Journal of Controlled Release, IF= 7.633, 2013,167:148–156
8.Qiang Peng, Zhi-Rong Zhang, Tao Gong, Guo-Qiang Chen,* Xun Sun,*A rapid-acting, long-acting insulin formulation based on a phospholipid complex loaded PHBHHx nanoparticles Biomaterials. IF= 7.404,2012;33,1583-1588
9.Hanmei Li, Hao Jiang, Mengnan Zhao, Yao Fu and Xun Sun*, Intracellular redox potential-responsive micelles based on polyethylenimine-cystaminepoly ( ε -caprolactone) block copolymer for enhanced miR-34a delivery, Polymer Chemistry, IF=5.368, 2015, 6, 1952–1960
10.Hanmei Li, Xun Sun*, Dong Zhao, Zhirong Zhang. A cell-specific Poly(ethylene glycol) Derivative with a wheat-like structure for efficient gene delivery. Molecular pharmaceutics. IF= 4.782,2012;9, 2974-2985.
11.Zhirong Zhong, Yu Wan, Sanjun Shi, Jianfeng Han, Zhirong Zhang, Xun Sun*. Co-delivery of Adenovirus and Carmustine by Anionic Liposomes with Synergistic Anti-tumor Effects. Pharmaceutical Research. IF= 4.093, 2012;29:145–157
12.SanJun Shi , ZhiRong Zhong , Jie Liu , ZhiRong Zhang, Xun Sun*, Tao Gong*. Solid Lipid Nanoparticles Loaded with Anti-microRNA Oligonucleotides (AMOs) for Suppression of MicroRNA-21 Functions in Human Lung Cancer Cells. Pharmaceutical Research. IF= 4.093, 2012;29:97-109
13.Zhirong Zhong, Jianfeng Han, Yu Wan, Zhirong Zhang, and Xun Sun*.Anionic Liposomes Enhance and Prolong Adenovirus-Mediated Gene Expression in Airway Epithelia in Vitro and in Vivo. Molecular pharmaceutics. IF=4.782, 2011;8(3):673-682.
14.Dong Zhao, Tao Gong, Di Zhu, Zhirong Zhang, Xun Sun?.Comprehensive comparison   of two new biodegradable gene carriers.  International Journal of Pharmaceutics. IF=3.350, 2011;413(1-2):260-270.



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