今天是:2017年7月26日 星期三 农历六月初四
龚涛 教授(博士生导师)
作者:佚名  来源:  发布时间:2016年02月10日  点击/评论:20660/0

简历
1987~1992 华西医科大学药学院药学专业,本科
1992~1995 华西医科大学药学院药剂学专业,药剂学专业硕士研究生
1995~2001 华西医科大学制药厂,工作
2001~2004四川大学华西药学院,药剂学专业博士研究生
2004~2011 四川大学华西药学院,讲师,副教授,硕士生导师
2011~至今 四川大学华西药学院,教授,博士生导师
    学术兼职:四川省药监局新药评审专家、国家药监局新药评审专家、中国药学会药剂专委会委员、四川省卫生厅学术技术带头人。《Biomaterials》、《Nanoscale》、《Molecular Pharmaceutics》、《Journal of Controlled Release》等国内外专业杂志的审稿人。
研究方向
1. 缓控释和微粒给药系统的关键技术及应用研究
2. 药物制剂新技术及其应用研究
主要研究课题及成果
纵向课题:
1. 子课题负责人, 可注射用辅料关键技术研究,科技部重大新药创制关键技术,编号:2011ZX09501-001-01,起止日期2010.5--2013.5
2. 课题负责人,穿心莲内酯包合物及其冻干粉针的研制,四川省科技支撑项目,编号:2008SZ0022,起止日期2008.01-2010.12
3. 课题负责人,PEPT2介导的以调控肺癌基因的miRNA为靶点的载寡聚核苷酸的肺部给药系统研究,国家自然科学基金面上项目,编号:30873165,起止日期2009.1-2011.12
4. 课题负责人,基于乙肝病毒的嗜肝性原理构建的肝实质细胞主动靶向给药系统的研究,国家自然科学基金面上项目,编号:81273443,起止日期2013.1-2016.12
5. 子课题负责人, “新释药系统关键技术及新产品产业化研究” 子课题:盐酸米托蒽醌脂质体注射液临床研究, 科技部重大新药创制,子课题编号:2014ZX09507001002,起止日期2014.01—2016.12
6. 子课题负责人,973项目“用于脑部肿瘤治疗的新型纳米药物研究,编号:2013CB932500”第四课题“脑部肿瘤系统靶向性纳米药物的工程化制备关键技术研究”,子课题编号:2013CB932504-2,起止日期 2013.1-2017.12
7.子课题负责人,治疗眼表新生血管相关疾病的I类生物药滴眼液的临床前研究,四川省科技支撑计划,子课题编号:2016KJT0017-2015SZ0019,起止日期2015.01—2017.12
8. 课题负责人,活化HSCs靶向递药系统的构建和用于肝纤维化精准治疗的研究,国家自然科学基金面上项目,编号:81673359,2017.1.1-2020.12.31
专利:
1.肾靶向前体药物、制剂及其制备方法与应用。发明专利授权号:ZL 200610020167.X, 发明人:张志荣,龚涛,孙逊,郑强
2. 一种肾靶向药物载体材料及与其形成的前药、制法和应用。发明专利授权号:ZL 200610020991.5,发明人:张志荣,龚涛,孙逊,袁志翔。
3.一种穿琥宁脂质体冻干粉制剂及其制备方法。发明专利授权号:ZL 200610022665.8,发明人:张志荣,龚涛
4.喜树碱衍生物磷脂复合物脂质纳米粒制剂及其制备方法。发明专利授权号:ZL 200710048481.3,发明人:张志荣,龚涛,卫薇。
5. 丹参酚酸B磷脂复合物及其制备方法   发明专利授权号:ZL 200710051038.1,发明人: 张志荣,龚涛,彭强
6. 一种细辛脑注射剂及其制备方法, 发明专利授权号:ZL 200910164296.X,发明人:许玉琼,龚涛,张志荣,梁臻
7. 一种α-细辛脑混合胶束注射剂及其制备方法、应用及其冻干粉针制剂, 发明专利授权号:ZL 200910059924.8,发明人:张志荣,龚涛,任春娟
8. 有机胺衍生物作为小分子药物脑靶向修饰基团的用途,发明专利授权号:ZL 201010144446.3,发明人: 张志荣,龚涛,孙逊、张宣、赵栋、刘兴
9. 一种提高生物利用度的氧化石蒜碱组合物及其制剂 ,发明专利授权号:ZL201210252981.X, 发明人:张志荣、龚涛、赵晖
10. 一种提高桑色素口服生物利用度的药物组合物,发明专利授权号:ZL201110275082.7,发明人: 张志荣、龚涛、张金洁、孙逊
11. 氨基葡萄糖衍生物作为小分子药物肾靶向修饰基团的用途,发明专利授权号:ZL201110262847.3,发明人: 张志荣 林燕 龚涛 孙逊 王晓虹
12. 一种9-硝基喜树碱混合胶束冻干粉针及其制备方法,申请号:201210035050.4, 发明人:龚涛、张志荣、孙逊、黄蕊
13.一种透明质酸-阳离子药物离子对微粒,发明专利,申请号:201510555003.6, 发明人:龚涛、张志荣、李文浩
14.一种肿瘤靶向的新型多肽发明专利,发明专利,申请号:201510650649.2,发明人:张志荣、龚涛、宋旭、陈体佳、符垚
15. 一种鬼臼毒素类药物的靶向给药制剂,发明专利,申请号:2014107700264, 发明人:龚涛、张志荣,和心依
16.一种达比加群酯纳米混合胶束及其制备方法,发明专利,申请日:2016-06-20,申请号:201610441009.5,发明人:龚涛、张志荣、胡梅
代表性论著
近年发表的主要论著有:
1. 张志荣主编,《靶向治疗分子基础与靶向药物设计》(第三章 脑靶向药物设计),科学出版社  2005.12
2.潘卫三主编,《工业药剂学》(第十四章 靶向制剂),中国医药出版社,2010.6
3. 蒋新国主编,《脑靶向递药系统》,人民卫生出版社(第七章 转运体介导的脑靶向递药),2011.5
4. 张志荣主编,《药剂学》,高等教育出版社,(第十四章 药物剂型与制剂的设计),北京,2014.3

近五年发表的主要论文:
1. Caifeng Deng, Quan Zhang,*,Yao Fu, Xun Sun, Tao Gong,*, and Zhirong Zhang  Coadministration of Oligomeric Hyaluronic Acid-Modified Liposomes with Tumor-Penetrating Peptide-iRGD Enhances the Antitumor Efficacy of Doxorubicin against Melanoma   ACS Appl. Mater. Interfaces 2017, 9, 1280?1292
2. Xu Song, Zhuoya Wan, Tijia Chen, Yao Fu, Kejun Jiang, Xiaoli Yi, Huan Ke, Jianxia Dong, Liuqing Yang, Lin Li, Xun Sun, Tao Gong*, Zhirong Zhang*  Development of a Multi-Target Peptide for Potentiating Chemotherapy by Modulating Tumor Microenvironment Biomaterials 108 (2016) 44-56 
3. Quan Zhang?, Caifeng Deng?, Yao Fu, Xun Sun, Tao Gong*, Zhirong Zhang   Repeated administration of hyaluronic acid coated liposomes with improved pharmacokinetics and reduced immune response  Molecular Pharmaceutics 2016,13(6)1800-1808
4.  Mengxin Wang, Fengyin San, Yang Zou, Xun Sun, Zhi-Rong Zhang, Yao Fu*, Tao Gong*   Pharmacokinetic and pharmacodynamic study of phospholipid-based phase separation gels for once a month administration of octreotide   Journal of Controlled Release  2016,230:45-56
5. Wenhao Li, Xiaoli Yi, Xing Liu, Zhirong Zhang, Yao Fu*, Tao Gong*   Hyaluronic acid ion-pairing nanoparticles for targeted tumor therapy    Journal of Controlled Release  225 (2016) 170–182
6. Jing-Wen Luo, Ting Zhang, Quan Zhang, Xi Cao, Xin Zeng, Yao Fu, Zhi-Rong Zhang, Tao Gong*   A novel injectable phospholipid gel co-loaded with doxorubicin and bromotetrandrine for resistant breast cancer treatment by intratumoral injection  Colloids and Surfaces B: Biointerfaces 140 (2016) 538–547
7. Nanxi Xiang, Xu Zhou, Xinyi He, Yu Zhang, Jinjie Zhang, Zhi-Rong Zhang, Xun Sun, Tao Gong*, Yao Fu*   An Injectable Gel Platform for the Prolonged Therapeutic Effect of Pitavastatin in the Management of Hyperlipidemia  Journal of Pharmaceutical Sciences 105 (2016) 1148--1155
8. Jing-Wen Luo, Zhi-Rong Zhang, Tao Gong*and Yao Fu*    one-step self-assembled nanomicelles for improving the oral bioavailability of nimodipine   International Journal of Nanomedicine   2016:11 1051–1065
9.  Xu Song,Qing Lin, Ling Guo,Yao Fu,Jianfeng Han, Huan Ke, Xun Sun, Tao Gong*,Zhirong Zhang*  Rifampicin Loaded Mannosylated Cationic Nanostructured Lipid Carriers for Alveolar Macrophage-specific Delivery  Pharm Res  2015,32(5):1741--1751
10. Ting Zhang?, Qiang Peng?, Feng-Ying San, Meng-Xin Wang, Wen-Qi Wu, Tao Gong*, Zhi-Rong Zhang*  A high-efficiency, low-toxicity, phospholipids-based phase separation gel for long-term delivery of peptides Biomaterials  45(2015)1-9 
11. Jinjie Zhang, Jianbo Li, Yuan Ju, Yao Fu, Tao Gong,* and Zhirong Zhang*   Mechanism of enhanced oral absorption of morin by phospholipid complex based self-nanoemulsifying drug delivery system  Molecular Pharmaceutics   2015,12(2):504-513 
12. Xinyi He, Nanxi Xiang, Jinjie Zhang, Yao Fu*, Tao Gong*  Encapsulation of teniposide into albumin nanoparticles with greatly lowered toxicity and enhanced antitumor activity  International Journal of Pharmaceutics  2015, 487(1-2)250–259 
13. Quan Zhang, Xuanmiao Zhang, Tijia Chen, Xinyi Wang, Yao Fu, Yun Jin,* Xun Sun, Tao Gong* and Zhirong Zhang    A safe and efficient hepatocyte-selective carrier system based on myristoylated preS1/21-47 domain of hepatitis B virus  Nanoscale, 2015, 7, 9298 - 9310 
14. Xiaoli Yi, Xianghong Lian, Jianxia Dong, Zhuoya Wan, Chunyu Xia, Xu Song, Yao Fu*  Tao Gong*  Zhirong Zhang   Co-delivery of pirarubicin and paclitaxel by human serum albumin nanoparticles to enhance antitumor effect and reduce systemic toxicity in breast cancers  Molecular Pharmaceutics  2015, 12 (11), pp 4085–4098 
15. Xuanmiao Zhang, Quan Zhang, Qiang Peng, Jing Zhou, Longfei Liao, Xun Sun, Ling Zhang*, Tao Gong*  Hepatitis B virus preS1-derived lipopeptide functionalized liposomes for targeting of hepatic cells  Biomaterials  35 (2014) 6130-6141
16. Wenqi Wu, Hui Chen , Fengying Shan, Jing Zhou, Xun Sun, Ling Zhang*, Tao Gong *  A novel doxorubicin-loaded in situ forming gel based on high concentration phospholipid for intratumoral drug delivery   Molecular Pharmaceutics  2014, 11 (10):3378–3385 
17. Longfei Liao, Mengtian Zhang, Huan Liu, Xuanmiao Zhang, Zhaolu Xie, Zhirong Zhang, Tao Gong* and Xun Sun*   Subchronic toxicity and immunotoxicity of MeO-PEG-poly(D,L-lactic-co-glycolic acid)-PEG-OMe triblock copolymer nanoparticles delivered intravenously into rats  Nanotechnology 25 (2014) 245705  
18. Xianghong Lian, Jianxia Dong, Jinjie Zhang, Yanwei Teng, Qing Lin, Yao Fu*,   Tao Gong*   Soluplus? based 9-nitrocamptothecin solid dispersion for peroral administration:Preparation, characterization, in vitro and in vivo evaluation   International Journal of Pharmaceutics  2014,477(1-2):399-407 
19. Zhen Liang, Man Li, Xun Sun, Tao Gong*, Zhirong Zhang*   A polymeric prodrug of 5-fluorouracil-1-acetic acid using a multi-hydroxyl polyethylene glycol derivative as the drug carrier    Plos One  2014, 9(11):1-13 
20. Ting Zhang, Yong Zheng, Qiang Peng, Xi Cao, Tao Gong*, Zhirong Zhang  A novel submicron emulsion system loaded with vincristine–oleic acid ion-pair complex with improved anticancer effect: in vitro and in vivo studies   International Journal of Nanomedicine  2013:8 1185–1196 
21. Hui Zhao, Hua Lu, Tao Gong*, Zhirong Zhang  Nanoemulsion loaded with lycobetaine-oleic acid ionic complex: physicochemical characteristics, in vitro, in vivo evaluation and antitumor activity   International Journal of Nanomedicine  2013:8 1959–1973
22. Likai Yang, Jing Luo, Sanjun Shi, Qiang Zhang, Xun Sun, Zhirong Zhang, Tao Gong*  Development of a pulmonary peptide delivery system using porous nanoparticle-aggregate particles for systemic application   International Journal of Pharmaceutics  451 (2013) 104–111
23. Jing Zhou, Xuanmiao Zhang, Mei Li, Wenqi Wu, Xun Sun, Ling Zhang*, Tao Gong*   Novel lipid hybrid albumin nanoparticle greatly lowered toxicity of pirarubicin   Molecular Pharmaceutics  2013, 10 (10):3832–3841 



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