今天是:2017年4月28日 星期五 农历四月初三
蒋学华 教授(博士生导师)
作者:佚名  来源:  发布时间:2016年02月16日  点击/评论:30371/0

单 位:四川大学华西药学院临床药学与药事管理学系 华西临床药学研究中心

通讯地址:成都市人民南路三段 17 号四川大学华西药学院

电话/传真:(028)85501370/85503024

E-mail:jxh1013@scu.edu.cn

简历

1978年3月~1981年12月,四川医学院药学系,药学专业学习,获医学学士学位;

1991年~1994年,华西医科大学药学院,药剂学专业博士研究生学习,获理学博士学位;

1982年1月~四川医学院药学系、华西医科大学药学院、四川大学华西药学院任助教、讲师、副教授、教授、博士研究生导师。

现为四川大学华西药学院临床药学与药事管理学系主任。

社会职务

教育部高等学校药学专业教学指导分委员会委员;

教育部高等学校高职高专药品类专业教学指导委员会委员;

全国高等学校临床药学专业(方向)教材评审委员会副主任委员;

中国药学会药事管理专业委员会委员;

中国药理学会药物代谢专业委员会委员;

中国医院协会药事管理专业委员会常务委员;

四川省药学会副理事长;

四川省临床药学专业委员会主任;

四川省卫生厅药学学术技术带头人

学术刊物任职:《药物分析杂志》、《中国循证医学杂志》、《中国医药导刊》、《中国执业药师》、《中国药师》、《华西

药学杂志》、《西北药学杂志》、《中南药学》、《西部医学》、《四川医学》、《实用医院临床杂志》、《儿科药学杂志》、

《药学与临床研究》等专业期刊编委。

研究方向

研究领域:生物药剂学、药动学、临床药学

研究方向:药动学与药物制剂生物等效性评价; 药物新制剂的设计与评价; 临床药学教育;

研究生招生专业与研究方向:

博士研究生:药剂学专业,剂型设计的生物药剂学原理研究;临床药学专业,临床用药的药动学基础研究;药事管理学专业,

药事法规与药事管理

硕士研究生:药剂学专业,药物新制剂及其生物等效性评价; 临床药学专业,临床药动学的研究与应用; 药事管理学专业,

药事法规与药事管理

主要研究课题及成果

主要学术成就简介

主要研究课题

国家自然科学基金:“抗癌药物器官靶向毫微粒给药系统质量评价研究”。批准号39570842;

国家科委医药技术创新博士项目:“肝靶向阿克拉霉素A毫微粒冻干针剂的研究”。合同编号:95-B-09;

国家自然科学基金:“中药口服给药系统设计与评价中的生物药剂学方法研究”。批准号:30070935;

国家自然科学基金:“中药制剂物质基础的细胞模型筛选方法研究”。批准号:30271614;

国家自然科学基金:“p-糖蛋白在口服中药制剂吸收中的作用与调控研究”,项目批准号30572373;

国家自然科学基金:基于代谢组学的中药引经理论的药动学基础研究, 项目批准号:30873441;

教育部博士点项目基金:“中药复方配伍原则的生物药剂学方法研究”,项目编号:20070610047,

教育部“新世纪高等教育教育改革工程” 项目“21世纪初药学人才培养模式研究与实践——药师型人才培养模式研究”,项目编号

1292B17212;

“新世纪四川省高等教育教学改革工程”教育教学改革项目 “临床药师型人才培养方案及课程体系和教学内容研究”;

四川省高等教育人才培养质量和教学改革项目“药事管理学教学内容改革及课程体系建设”;

中国高等教育学会医学教育专业委员会药学教育研究会2008年重点课题“我国临床药师型人才培养体系建设研究”;

中国教育资源协会CORE Lead University项目——“《药事管理学》精品课程英文版制作与国际开放”;

主要研究成果

“尿中异烟肼及其代谢物乙酰异烟肼的比色测定及汉藏135例乙酰化代谢测定”获1988年卫生部科学技术进步三等奖;

“药品溶液颜色检查法标准化研究”获1992年四川省科学技术进步三等奖;

“以诺氟沙星为模型药物考察毫微粒眼用新剂型的基础研究”,获1999年度四川省卫生厅科技进步三等奖;

“诺氟沙星毫微粒眼用新剂型的基础研究”,获2000年度成都市科技进步三等奖;

“21世纪初药师型人才培养模式研究与实践”,2004年获四川大学教学成果一等奖;

“21世纪初药学人才培养模式研究与实践——药师型人才培养模式研究”,获2005年四川省社科优秀成果奖;

“21世纪初药学人才培养模式研究与实践——药师型人才培养模式研究”,获2005年四川省高等教育学会社会科学研究优秀成果二等

奖;

“丹七新制剂设计与评价的生物药剂学方法研究”,获2008年四川省科技进步三等奖;

“药事管理学教学改革及课程体系建设”项目获得2008年四川省教育教学成果一等奖;

“药事管理学教学改革及课程体系建设”项目获得2008年四川大学校级教育教学成果一等奖;

“《药物现代评价方法》课程和教材建设”项目获得2008年四川大学校级教育教学成果二等奖;

《临床药动学》教材获四川大学2008年度校级优秀教材二等奖;

 
代表论著
 在国内外公开发表与药物研究各个环节相关论文260余篇,主要涉及药动学、生物药剂学、临床药学、药剂学、药学

教育等方面。近三年发表的SCI论文有:

1. Synthesis and Characterization of PEG-scutellarin Conjugates. A Potential PEG Ester Prodrug for the Oral Delivery of Scutellarin,Chinese Chemical letters,2006,17(1):85

2. Investigation of the Absorption Mechanisms of Baicalin and Baicalein in Rats,journal of pharmaceutical sciences,

2006,95(6):1326;

3. Determination of phillyrin in rat plasma by high- performances liquid chromatography and its application to phar-

macokinetic studies, journal of pharmaceutical and biomedical analysis,2006,41:628;

4. Determination of finasteride in human plasma by HPLC-MS,Asian Journal of Pharmacodynamics and Pharmacokinetics,

2006,6(3):196;

5. Studies of chlorogenic acid binding to different plasma proteins,Asian Journal of Pharmacodynamics and Pharma-

cokinetics,2006,6(3):235;

6. Synthesis , Characterization and in situ intestinal absorption of different molecular weight scutellarin-PEG

Conjugates. Pharmazie,2006,61(8):660;

7. Quantitative determination of isorhamnetin, quercetin and kaempferol in rat plasma by liquid chromatography with

electrospray ionization tandem mass spectrometry and its application to the pharmacokinetic study of isorhamnetin,

RAPID COMMUNICATIONS IN MASS SPECTROMETRY,2007; 21: 112;

8. Simple determination of Huperzine A inhuman plasma by Liquid chromatographic-tandem mass spectrometric method.

Biomedical Chromatography,2007,21:15;

9. Quantitative determination of rosuvastatin in human plasma by ion pair liquid-liquid extraction using liquid

chromatography with electrospray ionization tandem mass spectrometry. Journal of Pharmaceutical and Biomedical

Analysis, 2007, 44:540;

10. Effects of Labrasol and Other Pharmaceutical Excipients on the Intestinal Transport and Absorption of Rhodami-

ne123, a P-Glycoprotein Substrate, in Rats. Biol. Pharm. Bull. 2007,30(7) 1301;

11. Investigation on the Absorption Kinetics of Chlorogenic Acid in Rats by HPLC.Arch Pharm Res,2007 ,30(7):

911;

12. Complexation of tanshinone ⅡA with 2-hydroxypropyl-β-cyclodextrin:Effect on aqueous solubility, dissolution

rate,and intestinal absorption behavior in rats, International Journal of Pharmaceutics 2007,341:58;

13. Comparative cost-effectiveness of antiviral therapies in patients with chronic hepatitis B: A systematic review

of economic evidence. Journal of Gastroenterology and Hepatology ,2007,22 :1369;

14. Absorptive profile of chlorogenic acid in rats,Pharmazie 2007,62: 689;

15. Bioequivalence of Two Formulations of a single Oral Dose of 500mg Azithromycin Granules : A Randomized ,Open-

Label,Two-Period Crossover Study in Healthy Han Chinese volunteers. Current Therapeutic Research, 2007,68(57):369;

16. Investigation of the Improved Effects of 2-Hydroxypropyl-β-Cyclodextrin on Solubility, Dissolution Rate, and

Intestinal Absorptive Profile of Tanshinone IIA in Rats. Archives of Pharmacal Research 2007,30:1020;

17. Pharmacokinetics of rosuvastatin after single-dose, oral administration in Chinese volunteers:A Randomized,

Open-Label, Three-Way Crossover study, Clinical Therapeutics,2007,29(10):2194;

18. Pharmacokinetics of Huperzine A following oral administration to human volunteers, European journal of drug

metabolism and pharmacokinetics, 2007,32(4):183;

19. In Situ Intestinal Absorption Behaviors of Tanshinone IIA from Its Inclusion Complex with Hydroxypropyl-b–cyc-

lodextrin.Biol. Pharm. Bull. 2007,30(10) :1918;

20. Determination of forsythiaside in rat plasma by high-performance liquid chromatography and its application to

pharmacokinetic studies, Biomedical Chromatography 2008,22:361;

21. Simultaneous determination of vitexin-4''-O-glucoside and vitexin-2''-O-rhamnoside from hawthorn leaves

flavonoids in rat plasma by HPLC method and its application to pharmacokinetic studies,JOURNAL OF PHARMACEUTICAL

AND BIOMEDICAL ANALYSIS,2007,44(1)243;

22. MDR1 genotypes do not influence the absorption of a single oral dose of 600 mg valacyclovir in healthy Chinese

Han ethnic males,British Journal of Clinical Pharmacology,2008, 66(2): 247;

23. Rifaximin versus nonabsorbable disaccharides in the management of hepatic encephalopathy: a meta-analysis,

European Journal of Gastroenterology & Hepatology 2008, 20(11):1064;

24. L-Ornithine-L-aspartate in the management of hepatic encephalopathy: A meta-analysis Journal of Gastroenterology

and Hepatology,2008,(11):

25. Intra-herb pharmacokinetics interaction between quercetin and isorhamentin. Acta Pharmacologica Sinica ,2008,

29 (11):1376;

26. Bioequivalence evaluation of two d-limonene capsule formulations in healthy Chinese volunteers,Pharmazie,

2008,63: 718

参编教材

1. 主编:《药物现代评价方法》,人民卫生出版社,北京, 2008年;

2. 主编普通高等教育“十一五”国家级规划教材、全国高等学校药学类规划教材《临床药动学》,高等教育出版社,北京,2007年

3. 主编卫生部“十一五”规划教材,全国高等医药教材建设研究会规划教材《临床药学导论》,人民卫生出版社,北京, 2007年;

4. 主编:《药物评价方法概论》,四川大学出版社,成都, 2005年;

5. 参加编写:Advances in biopharmaceutical technology in china,“ Pharmacy and Administration in china,”,ES Illu-

station and Design,Inc.2006;

6. 参加编写教材:《生物药剂学与药物动力学》,高等教育出版社,2009年;

7. 参加编写普通高等教育“十一五”国家级规划教材、全国高等学校药学类规划教材《药物设计学》(第二版),北京,高等教育

出版社, 2008年;

8. 参加编写教材:《药学概论》,高等教育出版社,2007年;

9. 参加编写教材:《临床药学》,中国医药科技出版社,2007年;

10. 参加编写:《药物新剂型与新技术》(第二版),北京,人民卫生出版社,2005年;

11. 参加编写:《生物药剂学与药物动力学》(第二版),北京,人民卫生出版社,2003年;

12. 副主编:《国家基本医疗保险药品使用手册》,北京,劳动社会保障出版社, 2001年;

13. 参加编写:《实用临床药物动力学》,成都,四川大学出版社, 1997年;

14. 参加编写:《靶向给药制剂》,成都,四川科技出版社, 1997年;

 

Professor Xue-hua Jiang

Present Title and Position
Professor and Director
Department of Clinical Pharmacy & Pharmacy Administration,
West China School of Pharmacy,
Sichuan University.

Research areas:

Biopharmaceutics, Pharmacokinetics, Clinical Pharmacy

Research directions:

Clinical Pharmacokinetics and evaluation of bioavailability and bioequivalence study
Biopharmaceutics principles for design of drug formulation
Clinical Pharmacy education


Description of Research Background:

Prof. Jiang awarded several grants issued by National Natural Science Foundation of China (NNSFC), such as Role of P-gp in Absorption and Regulation of Oral Chinese Medicine Formulae, Study on the Method of Biopharmaceutical in Chinese Medicine Oral Delivery System,Study on screening method of cell model in material fundation of preparation of the Chinese medicine. In the studies, the Caco-2 monolayer model was for the first time utilized to screen the bio-active components of Traditional Chinese Medicine (TCM). Based on the bio active markers guided method using cell model, the Biopharmaceutics of Chinese Medicine was established and modernization of formulation of TCM was improved via regulating drug’s release and permeability through the cell membrane as well as the correlation of in vitro release and in vivo.

Prof. Jiang has completed two projects as the principal investigator related to target oriented drug delivery system, which are Study and Evaluation of Target Oriented Microparticle System for Anti-cancer Drugs (founded by NNSFC) and study of Liver Oriented Delivery System for Freeze-dry Powder Injector of Aclacinomycin A (Project founded by National Doctoral Medicine Technology and Innovation Committee). Upon finishing these projects, Prof. Jiang set up the guideline for quality control and evaluation of systemic target oriented drug delivery system and devoted to the research and development of the nanoparticle drug delivery system.
In addition to the research, Prof. Jiang also contributed a lot to the education of the clinical pharmaceutics and clinical pharmacy by participating in the establishment and practice of the undergraduate student education program. He was responsible as the principal for the education innovation projects sponsored by Ministry of Education and Sichuan province and other national continuous medical education projects. Prof Jiang made great contribution to the development of pharmaceutics and published more than 10 relevant articles. He is the well known as a clinical pharmaceutical educator and one of the founders of the subject of clinical pharmacy as well.
Prof Jiang set up a lot of programs for both undergraduate and postgraduate e.g. Biopharmaceutics and Pharmacokinetics, Clinical pharmacokinetics, Advanced Methods of Pharmaceutical Evaluation, Advanced Pharmacokinetics, Study methods for Clinical Pharmacy and Study methods for pharmacy administration. He is the key member of subject of the discipline of pharmacy administration.

Publications

1. Eric S. Langer:Advances in biopharmaceutical technology in china,Chapter 7,Pharmacy and Administration in china,ES Illustation and Design,Inc.2006,( ISBN 1-934106-00-3)

2. Rifaximin versus nonabsorbable disaccharides in the management of hepatic encephalopathy: a meta-analysis,European Journal of Gastroenterology & Hepatology 2008, 20(11):1064–1070

3. L-Ornithine-L-aspartate in the management of hepatic encephalopathy: A meta-analysis Journal of Gastroenterology and Hepatology,2008,(11):

4. Intra-herb pharmacokinetics interaction between quercetin and isorhamentin. Acta Pharmacologica Sinica ,2008, 29 (11):1376-1382

5. Bioequivalence evaluation of two d-limonene capsule formulations in healthy Chinese volunteers,Pharmazie, 2008,63: 718–720

6. MDR1 genotypes do not influence the absorption of a single oral dose of 600 mg valacyclovir in healthy Chinese Han ethnic males,British Journal of Clinical Pharmacology,2008, 66(2): 247–254

7. In Situ Intestinal Absorption Behaviors of Tanshinone IIA from Its Inclusion Complex with Hydroxypropyl-b –cyclodextrin.Biol. Pharm. Bull. 2007,30(10) 1918—1922

8. Determination of forsythiaside in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies, Biomedical Chromatography 2008,22:361-366

9. Simultaneous determination of vitexin-4''-O-glucoside and vitexin-2''-O-rhamnoside from hawthorn leaves flavonoids in rat plasma by HPLC method and its application to pharmacokinetic studies,JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2007,44(1)243-249

10. Bioequivalence of Two Formulations of a single Oral Dose of 500mg Azithromycin Granules : A Randomized ,Open-Label,Two-Period Crossover Study in Healthy Han Chinese volunteers. Current Therapeutic Research, 2007,68(57):369-377

11. Investigation of the Improved Effects of 2-Hydroxypropyl-β-Cyclodextrin on Solubility, Dissolution Rate, and Intestinal Absorptive Profile of Tanshinone IIA in Rats. Archives of Pharmacal Research 2007,30:1020-1026

12. Pharmacokinetic Properties of Rosuvastatin After Single-Dose, Oral Administration in Chinese Volunteers: A Randomized, Open-Label, Three-Way Crossover Study, Clinical Therapeutics,2007,29(10):2194-2203

13. Pharmacokinetics of Huperzine A following oral administration to human volunteers, European journal of drug metabolism and pharmacokinetics, 2007,32(4):183-187

14. Comparative cost-effectiveness of antiviral therapies in patients with chronic hepatitis B: A systematic review of economic evidence. Journal of Gastroenterology and Hepatology ,2007,22 :1369–1377

15. Absorptive profile of chlorogenic acid in rats,Pharmazie 2007,62: 689–692

16. Complexation of tanshinone ⅡA with 2-hydroxypropyl-β-cyclodextrin:Effect on aqueous solubility, dissolution rate,and intestinal absorption behavior in rats, International Journal of Pharmaceutics 2007,341:58-67

17. Effects of Labrasol and Other Pharmaceutical Excipients on the Intestinal Transport and Absorption of Rhodamine123, a P-Glycoprotein Substrate, in Rats. Biol. Pharm. Bull. 2007,30(7) 1301—1307

18. Investigation on the Absorption Kinetics of Chlorogenic Acid in Rats by HPLC.Arch Pharm Res,2007 ,30(7):911-916

19. Quantitative determination of rosuvastatin in human plasma by ion pair liquid-liquid extraction using liquid chromatography with electrospray ionization tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 2007, 44:540-546

20. Quantitative determination of isorhamnetin, quercetin and kaempferol in rat plasma by liquid chromatography with electrospray ionization tandem mass spectrometry and its application to the pharmacokinetic study of isorhamnetin,RAPID COMMUNICATIONS IN MASS SPECTROMETRY,2007; 21: 112–120

21. Simple determination of Huperzine A inhuman plasma by Liquid chromatographic-tandem mass spectrometric method.Biomedical Chromatography,2007,21:15-20



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