今天是:2017年6月25日 星期日 农历六月初二
叶利明 研究员(硕士生导师)
作者:佚名  来源:  发布时间:2016年02月13日  点击/评论:12122/0

 叶利明 研究员(博士,硕士生导师)

 单位:四川大学华西药学院分析测试中心

 通讯地址:成都市人民南路三段17号四川大学华西药学院

 电话:028-85502305 E-mail:dyelimin@126.com

 职务:华西药学院分析测试中心主任

 

简历

1984 毕业于华西医科大学药学院,药物化学本科

1997 毕业于华西医科大学药学院,获理硕士学位

2008 毕业于四川大学华西药学院,获医学博士学位

1984年~至今 四川大学华西药学院中心测试室任助教、讲师、副教授、研究员

19911月~8 西藏自治区卫生学校自愿援藏教师

研究方向

1. 药物定量保留-活性关系预测模型研究

2. 药动学及药物代谢产物研究

3. NIR在线测定系统方法学及应用研究

4. 中药及中药材质量标准研究

5. 化学药质量标准研究

主要研究课题及成果

1. 靶向释药系统与新制剂技术平台的建设。国家重大新药创制科技重大专项课题(立项编号:2009ZX09310-002),2009—2010,参研

2.中药绵马贯众饮片炮制规范化研究中的质量标准研究(子课题)(十五国家科技攻关,批准号20011701BA701A11),子课题负责人

3. 国家科技支撑计划课题(多糖类功能食品有效成分检测和鉴伪技术的研究-降压类功能食品中违禁添加成分的HPLCLC-MS检测方法研究,批准号2006BAD27B02)子课题负责人

4. 中药成分受体的肝胞内靶向给药系统的研究(国家自然科学基金,批准号30271613),第一主研

5. 槟榔炒制过程中物质基础与生物效应动态变化规律研究。国家自然科学基金(批准号30973942)。子课题负责人

6. 川产法定挥发性药材指纹图谱研究(四川省中医药管理局课题,批准号H0020),负责人

7. 新型纤溶活性物质枯激酶的应用研究(四川省科技攻关项目,批准号36001),第一主研

8. 国家一类新药KB药学研究质量标准项,负责人。

主要科研和教学情况

     完成和参与国家自然科学基金项目2项,国家十一五重大科技专项重大新药创制单元平台项目1项,国家十五重大

科技项目1项,国家科技支撑计划课题项目1项,四川省重点项目2项,其他横向课题32项。发表论文80余篇,其中SCIEI收录30余篇。申请发明专利1项。获四川省科技进步奖三等奖1项,获得成都市科学技术奖励二等奖2项。为博士、硕士研究生课堂讲授《分析化学》,《现代仪器分析》(红外,紫外,薄层扫描,质谱章节),《药物研究新技术与新方法》(质谱新技术章节),《食品药品分析仪器联用技术选论》,《药物分析学选论》和《药物分析专业英语》课程。

指导博士3名;培养毕业硕士27名。其中所培养硕士研究生1名获2009年度宝钢国家奖。

代表论著

张志荣, 胡清学, 叶利明. 《现代仪器联用分析》 成都科技大学出版社,1989,第一版

发表论文(英文2007年以来):

 

1Shurong Wang, Yu Cheng, Zhaoxia Gao, Meijin Xiong, Zhirong Zhang, Liming Ye*. Gas chromatographic-mass spectrometric analysis of d-limonene in human plasma. Journal of Pharmaceutical and Biomedical Analysis. 2007, 44: 1095 - 1099

2Qiang Zheng, Liming Ye, Rong Gao, Jing Han, Meijin Xiong, Dong Zhao, Tao GongKinetic release of triptolide after injection of renal-targeting 14-succinyl triptolide-lysozyme in a rat kidney study by liquid chromatography / mass spectrometry. Biomedical Chromatography. 2007, 21: 724–729.

3Shu-Rong Wang, Yu Chen, Li-Ping Wu, Wen-Juan Miao, Mei-Jin Xiong, Cong Chen, Zhi-Rong Zhong and Li-Ming Ye*. Development of predictive quantitative retention-activity relationship models of HMG-CoA reductase inhibitors by biopartitioning micellar chromatography. Journal of Pharmaceutical and Biomedical Analysis. 2008, (2): 243-249

4Li-Ping Wu, Yu Chen, Shu-Rong Wang, Cong Chen, Li-Ming Ye*. Quantitative retention-activity relationship models for quinolones using biopartitioning micellar chromatography. Biomedical Chromatography. 2008, 22(1):106-114

5Li-ping Wu, Li-ming Ye, Cong Chen, Jia-qi Wu, Yu Chen. Biopartitioning micellar chromatography separation methods: modelling quantitative retention-activity relationships of cephalosporins. Biomedical Chromatography. 2008, 22: 606-615.

6Li-ping Wu, Yan Cui, Mei-jin Xiong, Shu-rong Wang, Cong Chen and Li-ming Ye *. Mixed micellar chromatography methods: modelling quantitative retention–activity relationships of angiotensin converting enzyme inhibitors. Biomedical Chromatography. 2008, 22(11):1243-1251

7Ke Lan, Xuehua Jiang, Yunxia Li, Ling Wang, Jing Zhou, Qian Jiang and Limin Ye. Quantitative determination of rosuvastatin in human plasma by ion pair liquid–liquid extraction using liquid chromatography with electrospray ionization tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. 2007, 44: 540-546.

8. Shu-Rong Wang, Cong Chen, Mei-Jin Xiong, Li-Ping Wu, Li-Ming Ye*, Cong Chen. Quantitative retention-activity relationship models of angiotensin enzyme inhibitors using biopartitioning micellar chromatography. Journal of Chromatographic Science. 2010, 48 (2): 134-138

9. Yu Chen, Li-Ping Wu, Li-Ming Ye* Cong Chen. Development of predictive quantitative retention-activity relationship models of alkaloids by mixed micellar liquid chromatography. Biomedical Chromatography. 2010, 24(2):195-201

10.Yan Cui , HaiLinYin , Xu Bao , MeiJin Xiong , Cong Chen and LiMing
Ye *. Determination of penehyclidine hydrochloride in beagle dog plasma by liquid chromatography electro spray ionization mass spectrometry and the pharmacokinetic study. Journal of Chinese Pharmaceutical Sciences. 2008, 17
32-38

11.Jian Zhong Wang*, Li Ming Ye, Xiao Bing Chen. A new C27-steroidal glycoside from Ophiogon japonicus. Chinese Chemical Letters. 2008, 19 (1): 82-84

12. Zhang Z, Sun W, Luo P, Wu L, Ye L, Zhang H. Simultaneous determination of five main active constituents of Erigeron multiradiatus by HPLC-DAD-MS. Journal of Pharmaceutical and Biomedical Analysis. 2008, 48 (3): 980-985.

13. Xiao-Juan Ren , Shu-Rong Wang, Yu-Jie Liu, Li-Ping Wu, Cong Chen,Li-Ming Ye*.
Effect of acidity of drugs on the prediction for human oral absorption by biopartitioning micellar chromatography. AJXJU(Academic Journal of Xi’an Jiaotong University).2010.229(4):233
240

14. Jintao Xue , Chunjie Wu, Leilei Wang, Su Jiang , Guo Huang , Jiliang Zhang , Silan Wen, Liming Ye*.Dynamic prediction models for alkaloid content using NIR technology for the
4 study and online analysis of parching in Areca Seed. Food Chemistry.2011 (126): 725
730

15. Si-Lan Wen*, Yu-Jie Liu*, Hai-Lin Yin , Liu Zhang*, Jin Xiao, Hong-Yuan Zhu , Jin-Tao Xue* and Li-Ming Ye*.Effect of Acupuncture on Rats with Acute Gouty Arthritis Inflammation: A Metabonomic Method for Profiling of both Urine and Plasma Metabolic Perturbation. AJCM(The American Journal of Chinese Medicine). 2011.39 (2) : 287300

16. Intra-herb pharmacokinetics interaction between quercetin and isorhamentinLan, K., He, J.-L., ian, Y., Tan, F., Jiang, X.-H., Wang, L., Ye, L.-M. Acta Pharmacologica Sinica 2008 29111376 - 1382 

17. Jintao Xue , Chunjie Wu, Leilei Wang, Su Jiang , Guo Huang , Jiliang Zhang , Silan Wen, Liming Ye*.Rapid and Automated Analytical Method for Identification of the

Types of Parched Areca Seed by Near Infrared Spectroscopy. Asian Journal of Chemistry; 2011 (22) 12:6543

18. Yan Liang, Xiao Juan Ren, Jin Tao Xue,Si Lan Wen ,Cong Chen ,Li Ming Ye* Development of QSAR/QRAR methods by biopartioning micellar chromatography and application in prediction of oral absorption of bioactive ingredients in Traditional Chinese Medicines. Asian Journal of Chemistry. 2013 (25) 3: 1525-1530

19. Yan Liang,  Zong-Ling Yin, Jing-Jing Zhang, Qi-Bing Zhang, Zhong-Xia Wang, Xiao –Juan Ren, Jian Chen, Li –Ming Ye*  Release test of alliin /alliinase double-layer tablet by HPLC. Journal of Pharmaceutical Analysis 2012 ( 4 ) 4 : 1234

20. Han Chen, Yan Liang, Xiao Juan Ren, Dong Mei Xiong, Shu Rong Wang, Li Ping Wu, Cong Chen, Li Ming Ye* . Studies effect of acid-base property in conjunction with molecular descriptors for chemical drugs and bioactive ingredients of Traditional Chinese Medicine on prediction of oral absorption by biopartioning micellar chromatography. Asian Journal of Chemistry; 2013 (25)15:8431-8443

21. Xue Jintao, Chen Han, Xiong Dongmei, Huang Guo, Ai Hong, Liang Yan, Yan Xinyu, Gan Yuan, Chen Cong, Chao Ruobing. Ye Liming *. Noninvasive Measurement of Glucose in Artificial Plasma with Near-Infrared (NIR) and Raman Spectroscopy Applied. Spectroscopy.2014 (68)04:08

22D.M.XIONG,  Z. LIU, H. CHEN, J.T. XUE, Y. YANG, C. CHEN, L.M.YE,* . Profiling the dynamics of Abscisic acid and ABA-glucose ester after using the glucosyltransferase  UGT71C5 to mediate abscisic acid homeostasis in Arabidopsis thaliana by HPLC-ESI-MS/MS .Journal of Pharmaceutical Analysis. 2014 (accepted)

23. D.M.XIONG, ? S.L.WEN,? H.CHEN,? X.BAO,? * and L.M.YE?*. Determination of Leuprolide in Beagle Dogs’ serum by High Performance Liquid Chromatography-mass Spectrometry and Study on Bioequivalence. Asian Journal of Chemistry; 2013 (25)18:15826-15831

24. Yuan Gan, Yan Liang, Han Chen,Jin Tao Xue,Yu Xin Yan,Mei Dong Xiong,

Cong Chen, Ming Li Ye*,, Ting Xu, Yu Chen. Prediction and Screening of Biologically Active Compounds In Honeysuckle (Lonicera japonica) by Biopartitioning Micellar Chromatography. Asian Journal of Chemistry; 2014 (26)

 



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