今天是:2017年11月20日 星期一 农历十月初三
徐亮 教授 (博士生导师)
作者:佚名  来源:  发布时间:2016年02月08日  点击/评论:14134/0

徐  亮 教授 (博士生导师)

单位:四川大学华西药学院天然药物化学教研室

通讯地址:成都市人民南路三段17号四川大学华西药学院

电话/传真:(028)85503046

E-mail: liangxu@scu.edu.cn


简历

1993~1997 华西医科大学药学院获理学学士学位

1997~2000 华西医科大学药学院获药物化学硕士学位

2000~2003 四川大学华西药学院获药物化学博士学位, 师从王锋鹏教授

2003~2005 中科院上海有机化学研究所博士后, 师从林国强院士

2005~2007 美国科罗拉多州立大学化学系博士后, 师从史一安教授

2007~ 2015 四川大学华西药学院副教授

2015~ 至今 四川大学华西药学院教授


研究方向

1. 不对称合成新方法学及其在天然药物分子合成中的应用

2. 活性天然含氮有机物的全合成研究


主要研究课题及成果

1. 新型手性氮杂环卡宾配体的合成及其在钯催化不对称反应中的应用(国家自然科学基金青年基金,起止日期2010-2012, 负责人)

2. 具有多环稠合复杂结构和高度生物活性的C19-二萜生物碱-甲基牛扁碱的全合成研究(国家自然科学基金面上项目,起止日期2013-2016, 负责人)

3. 新型二萜atropurpuran和二萜生物碱arcutin及其天然衍生物的仿生不对称全合成(国家自然科学基金面上项目,起止日期2015-2016, 负责人)

4. 二萜生物碱methyllycaconitine和racemulosine的全合成研究(四川大学优秀青年基金,2013至2016,负责人)

5. 应用代谢组学技术系统研究乌头碱类镇痛药的体内活性毒性代谢产物(国家自然科学基金青年基金,起止日期2014-2016, 主要参与)


所获奖励

1. 2009和2012年度四川大学青年骨干教师奖

2. 教育部自然科学一等奖:药用草乌化学成分的系统研究(排名第五)


发表论文

1. Dai-Hui Tang, Ding Ma, Hang Cheng, Yong-Li Li, and Liang Xu*, A bio-inspired synthetic route to the core ring systems of Spiraea atisine-type diterpenoid alkaloids and related diterpenes, Org. Biomol. Chem. 2016, 14, 2716–2722.


2. Min-Li Jiang, Yin-Juan Meng, Wei-Yan Xiong, Liang Xu*, Construction of functionalized ABEF ring system of C20-diterpenoid alkaloid racemulosine, Tetrahedron Lett. 2016, 57, 1610–1612.


3. Hang Cheng, Fan-Hao Zeng, Xue Yang, Yin-Juan Meng, Liang Xu*, and Feng-Peng Wang,Collective Total Syntheses of Atisane-Type Diterpenes and Atisine-Type Diterpenoid Alkaloids: (±)-Spiramilactone B, (±)-Spiraminol, (±)-Dihydroajaconine, and (±)-Spiramines C and D, Angew. Chem. Int. Ed. 2016, 55, 392 –396. (Highlighted by Chin. J. Org. Chem. 2016, 36, 437; Synfacts 2016, 12, 0119).


4. Jie Li, Liang Xu*, Novel C2-symmetric six-membered NHCs for asymmetric copper-catalysed conjugate addition of Grignard reagents to 3-methylhexenone, Tetrahedron 2015, 71, 2858?2862.


5. Ding Ma, Hang Cheng, Chunmei Huang, Liang Xu*, Synthesis of the azatricyclic ACD ring system of calyciphylline A-type Daphniphyllum alkaloids via a nonstabilized azomethine ylide generated by desilylation, Tetrahedron Lett. 2015, 56, 2492–2495.


6. Wei Zhang, Hang Cheng, Yongli Li, Chunmei Huang, Liang Xu*, A new approach toward the bicyclo[3.2.1]octenes via a carbocation-based cyclization from unusually functionalized seven-membered ring precursors, Tetrahedron 2015, 71, 4967?4973.


7. Hang Cheng, Fan-HaoZeng, Ding Ma, Min-Li Jiang, Liang Xu*, and Feng-Peng Wang, Expedient Construction of the ABEF Azatetracyclic Ring Systems of Lycoctonine-Type and 7,17-seco-Type C19-Diterpenoid Alkaloids, Org. Lett. 2014, 16, 2299?2301.


8. Ru-Huai Mei, Zhi-Gang Liu, Hang Cheng, Liang Xu*, and Feng-Peng Wang, Synthesis of the 10-Azatricyclo[3.3.2.04,8]decane Core of C20-Diterpenoid Alkaloid Racemulsonine via Iodine(III) Promoted Transannular Aziridination Reaction, Org. Lett. 2013, 15, 2206?2309.


9. Zhi-Gang Liu, Hang Cheng, Meng-Jia Ge, Liang Xu*, Feng-Peng Wang PIDA-promoted intramolecular transannular aziridination to synthesize bridged azatricyclic amines related to methyllycaconitine, Tetrahedron 2013, 69, 5431-5437.


10. Zhi-Gang Liu, Liang Xu*, Qiao-Hong Chen, Feng-Peng Wang, Construction of A/E/F ring systems of C19-diterpenoid alkaloids with both C-1and C-6 oxygen functions Tetrahedron 2012, 68, 159?165.


11. Hang Cheng, Liang Xu*, De-Lin Chen, Qiao-Hong Chen, Feng-Peng Wang, Construc-tion of functionalized B/C/D ring system of C19-diterpenoid alkaloids via intramolecularDielseAlder reaction followed by Wagner-Meerwein rearrangement Tetrahedron 2012, 68, 1171?1176.


12. Jie Li, Liang Xu*, Feng-Peng Wang, New cytotoxic Myrsinane_typediterpenes from Euphorbia prolifera, Helv. Chim. Acta. 2010, 93, 746.


研究生及博士后期间:

1. Jiang Long, Liang Xu, Haifeng Du, Kai Li and Yian Shi, Mechanistic Studies on a Dipeptide-Promoted Asymmetric Cyclopropanation of Unfunctionalized Olefins, Org. Lett. 2009, 11, 5226–5229.

2. Hong-Fu Lu, Xun Sun, Liang Xu, Li-Guang Lou, Guo-Qiang Lin, Design, synthesis and biological evaluation of novel fluorinated docetaxel analogues,Eur. J. Med. Chem. 2008, doi:10.1016 /j.ejmech.2008.04.004.

3. Liang Xu, Yian Shi, Chiral N-Heterocyclic Carbene-Pd(0) Catalyzed Asymmetric Diamination of Conjugated Dienes and Triene, J. Org. Chem. 2008, 73, 749

4. Liang Xu, Haifeng Du, and Yian Shi, Diamination of Conjugated Dienes and Trienes Catalyzed by N-Heterocyclic Carbene-Pd(0) Complexes. J. Org. Chem. 2007, 72, 7038.

5. Liang Xu, Jian-li Wang, Feng-peng Wang, Novel Rearrangement Products of the Degrated Derivative of Maoecrystal A, An ent-Kaurane-Type Diterpene, J. Asia Nat. Prod. Res. 2007, 9, 239.

6. Liang Xu, Feng-peng Wang, An Attempt to Enlarge the B ring of Maoecrystal B, an ent-Kaurane-type Diterpene, J. Asia Nat. Prod. Res. 2006, 8, 545.

7. Liang Xu, and Feng-Peng Wang, Exhaustive Degradation of the Ring D of 3,20-Epoxy ent-Kaurane-Type Diterpene Maoecrystal A. Tetrahedron, 2005, 61, 4467.

8. Feng-Peng Wang, and Liang Xu, To Seek an Approach Toward the Chemical Conversion of C19- diterpenoid Alkaloids to Taxoids. Tetrahedron, 2005, 61, 2149.

9. Liang Xu, Qiao-hong Chen, Feng-peng Wang, A Novel Skeletal Rearrangement of the A Ring of the Immonium Salt Derived from Norditerpenoid Alkaloid Yunaconitine, Tetrahetron, 2002, 58, 4267.

10. Qiao-hong Chen, Liang Xu, Feng-peng Wang, A Novel Conversion of Norditerpenoid Alkaloids into Aconane-Type Diterpenes, Tetrahetron, 2002, 58, 9431.

11. Qiao-hong Chen, Liang Xu, Feng-peng Wang, A New Access to the Cleavage of the N,19-Bond of Norditerpenoid Alkaloids and Their Derivatives by Formation of Oxaziridines, Heterocycles, 2002, 57, 2357.

12. Zheng-bang Li, Liang Xu, Xi-xianJian and Feng-peng Wang, New Norditerpenoid alkaloids from the roots of Aconitum geniculatum. J. Asia Nat. Prod. Res.2001, 3, 131.

13. Qiao-Hong Chen, Liang Xu,Feng-peng Wang, Preparation of the N,19-seco norditerpenoid alkaloids from norditerpenoid alkaloid yunaconitine, Chin .Chem. Lett, 2003, 14, 147




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