今天是:2017年7月26日 星期三 农历六月初四
张志荣 教授(博士生导师)
作者:佚名  来源:  发布时间:2016年03月11日  点击/评论:42912/0

 位:四川大学华西药学院  靶向药物及释药系统教育部重点实验室

通讯地址: 成都市人民南路三段十七号华西药学院

电话/传真: 028-85501566/028-85501615

电子邮件: zrzzl@vip.sina.com          

       

 

  

19821月本科毕业于四川医学院药学专业,获学士学位。

19821--19888月任华西医科大学药学院仪器分析教员、助教、讲师。

19937月研究生毕业于华西医科大学药剂学专业,获理学博士学位。

199312月任华西医科大学药学院药剂学副教授。

19979月任药剂学教授。

19981月聘为博士研究生导师。

19991月任华西医科大学药学院院长。

1999年获国家杰出青年科学基金资助。

2000年入选国家百千万人才工程一、二层次。任四川大学华西药学院院长。

 

主要学术兼职

- 国务院学位委员会药学学科评议组成员(第五、六届);

- 国家973计划健康科学领域专家咨询组专家;

- 国家药典委员会执行委员暨药用辅料与药包材专业委员会主任;

- 普通高等医药院校“十三五”药学类规划教材(科学出版社)专家委员会主任;

- 全国高等医药院校药学类规划教材(中国医药科技出版社)编写委员会副主任;

- 全国高等学校药学专业教材(人民卫生出版社)第四、五届评审委员会副主任;

- 全国高等医学教育学会药学教育研究会副理事长;

- 四川省药学会理事长;

- 《华西药学杂志》、《中国药剂学杂志》(网络版)主编;《中草药》、《中国药学年鉴》副主编;《药学学报》、《中国药学杂志》、《中国抗生素杂志》、《中国医药工业杂志》、《Asian Journal of Pharmaceutical Sciences》等10余个杂志编委。

 

主要研究方向

靶向药物与释药系统研究。

 

主要科研和教学情况

      在药物传递系统特别是靶向给药系统及新药开发研究等方面做了一些有价值的工作。近10年来,负责国家杰出青年科学基金项目1项,国家自然科学基金重点项目2项,国家自然科学基金面上项目7项,国家“863”计划课题2项,国家十一五重大科技专项重大新药创制单元平台项目2项,国家973计划课题1项,教育部、四川省项目10余项。主编、副主编出版专著、教材、参考书12。以第一或通讯作者发表论文300余篇,其中SCI收录118篇。主研、参研新药10个,其中主研的松龄血脉康胶囊已载入《中国药典》和国家基本药物目录。申请发明专利14项,授权11项。获四川省科技进步奖一等奖3项(排名第一)、二等奖2项、三等奖3项;获教育部科技进步奖三等奖1项。指导博士后18名;培养毕业博士52名、硕士69名。指导的博士研究生论文获全国百篇优秀博士论文奖1篇,提名奖1篇。

 

主要在研项目

1.张志荣负责,以直链小分子叔胺为导向的脑内高效递药系统研究。国家自然科学基金重点项目(批准号:81130060),2012.12016.12260万元。

2.张志荣负责,符合GLP要求的新制剂与新释药系统技术平台建设---靶向释药系统及新制剂技术平台建设。国家重大科技专项重大新药创制十二五课题(立项编号:2011ZX09310-002),2012.12015.12268万元。

3. 张志荣、何勤负责,脑部肿瘤系统靶向纳米药物的工程化制备关键技术。国家纳米重大科学研究计划课题(批准号:2013CB932504);2013.12017.12269万元

4.张志荣负责,针对急性胰腺炎的胰腺和肺双器官靶向递药系统研究。国家自然科学基金项目(批准号:81473169),2015.12018.12110万元

5.药物新剂型新制剂的应用基础研究。重庆药友制药有限公司合作项目,2010.12019.121000万元。

 

20142015年发表的主要论著

1. Xiawei Wei*, Bin Shao, Zhiyao He, Tinghong Ye, Min Luo, Yaxiong Sang, Xiao Liang, Wei Wang, Shuntao Luo, Shengyong Yang, Changyang Gong, Maling Gou, Hongxing Deng, Yinglan Zhao, Hanshuo Yang, Chengjian Zhao, Li Yang, Zhiyong Qian, Xun Sun, Jiahuai Han, Chengyu Jiang , Shuang Zhang, Min Wu, Zhirong Zhang*. Cationic Nanocarriers Induce Cell Necrosis through Impairment of Na+/K+-ATPase and Cause Subsequent Inflammatory Response. Cell Research, 2015; 25:1-17. doi:10.1038/cr2015.9, IF=12.413.

2.Jianbo Li*, Jinjie Zhang*, Yao Fu, Xun Sun, Tao Gong, Zhirong Zhang**. Dual-specific targeting therapy mediated by a phenolic propanediamine moiety for local and systemic complications of acute pancreatitis. Journal of Controlled Release2015;212:19-29. IF=7.705

3. Ting Zhang, Qiang Peng, Fenying San, Mengxin Wang, Wenqi Wu, Tao Gong*, Zhirong Zhang*. Sustained delivery of peptides and proteins by high content phospholipids-based phase separation gel. Biomaterials, 2015;45:1-9. IF=8.557.

4. Qi Wang, Peifeng Liu, Ying Sun, Tao Gong, Mingjie Zhu, Xun Sun, Zhirong Zhang*,Yourong Duan*. Preparation and properties of biocompatible PS-PEG/ Calcium phosphate nanospheres. Nanotoxicology, DOI:10.3109/17435390.2014. 911381. IF=7.336

5. Cheng Yan*; Zhu Biyue; Deng Yue; Zhang Zhirong*. In Vivo Detection of Cerebral Amyloid Fibrils with Smart DCM-Based Fluorescence Probe. Analytical Chemistry, 2015;87(9):4781-4787. doi: 10.1021/acs.analchem.5b00017. IF=5.825.

6.Yanping Li, Yangyang Zhou, Jiang, Jiayu; Xinyi Wang, Yao Fu, Tao Gong, Xun Sun, Zhirong Zhang*. Brain-targeting mechanism of dexibuprofen prodrugs modified with ethanolamine-related structures. Journal of Cerebral Blood Flow and Metabolism. 2015 00,1-10,doi:10.1038/jcbfm.2015.160, IF=5.407.

7. Xinyi Wang, Jianbo Li, Chaoqun Xu, Yanping Li, Tao Gong, Xun Sun, Yao Fu, Qin He, Zhirong Zhang*. Scopine as a novel brain-targeting moiety enhances the brain uptake of chlorambucil. Bioconjugate Chemistry, 2014,doi:10.1021/bc5004108,  IF=4.821.

8. Yuxuan Zhu, Xun Sun, Tao Gong, Qin He, Zhirong Zhang*. Antioxidant and antiapoptotic effects of 1,1'-(biphenyl-4,4'-diyl)-bis(3- (dimethylamino)-propan -1-one) protect PC12 cells from Aβ-induced injury. Molecular Pharmaceutics. 2014,11,428-435 . IF=4.787

9. Yanping Li; Yangyang Zhou; Bowen Qi; Gong Tao; Xun Sun; Yao Fu; Zhi-Rong Zhang*. Brain-specific delivery of dopamine mediated by N,N-dimethyl amino group for the treatment of Parkinson’s disease. Molecular Pharmaceutics. 2014, doi.org/10.1021/mp500352pl. IF=4.787.

10.Xiaohong Wang, Menghua Xiong, Yingchun Zeng, Xun Sun, Tao Gong, Zhirong Zhang*. A new conjugate: MGC in attenuating renal Ischemia/Reperfusion Injury. Molecular Pharmaceutics. 2014, doi.org/10.1021/mp500282g, IF=4.787.

11.Jingjie Zhang, Tao Gong*, Zhirong Zhang*. Mechanism of enhanced oral absorption of morin by phospholipid complex based self-nanoemulsifying drug delivery system. Molecular Pharmaceutics. doi.10.1021/mp5005806, IF=4.787

12.Xu Song, Qing Lin, Ling Guo, Yao Fu, Jianfeng HanHuan Ke, Xun Sun, Tao Gong*, Zhirong Zhang*. Rifampicin loaded mannosylated cationic nanostructured lipid carriers for dual-targeting to alveolar macrophages. Pharmaceutical Resaerch. 2014,doi:10. 1007/s11095-014-1572-3,IF=3.952.

13.Jingxin Mo, Lee Yong Lim* and Zhirong Zhang*. L-carnitine Ester of Prednisolone: Pharmacokinetic and pharmacodynamic evaluation of a Type I Prodrug. International Journal Pharmaceutics. 2014;475:e123-e129. IF=3.785.

14.Qin Zhang, Yao Fu, Renhe Liu, Tao Gong, Xun Sun, Zhi-Rong Zhang*. Renal-specific delivery of Prednisolone-folate conjugates for renal ischemia/ reperfusion injury. RSC Advanceds, 2014(4):5082850831. IF=3.708.

15.Man Li, Zhen Liang, Xun Sun, Tao Gong*, Zhirong Zhang*. A Polymeric Prodrug of 5-Fluorouracil-1-Acetic Acid Using a Multi-Hydroxyl Polyethylene Glycol Derivative as the Drug Carrier. Plos One, 2014,9(11):e112888. IF=3.534.

16.Peng Zhou, Xun Sun, Tao Gong, Zhirong Zhang*, Ling Zhang*. Conjugating glucosamine to triptolide to enhance its protective effect against renal ischemia- reperfusion injury and reduce its toxicity. Journal of drug targeting2014; 22(3): 200-210.IF=2.723.

17.Qi Wang, Pei Liu, Peifeng Liu, Tao Gong, Suming Li, Yourong Duan*, Zhirong Zhang*. Preparation, blood coagulation and cell compatibility evaluation of chitosan-graft-polylactide copolymers. Biomedical Materials, 9(2014)015007 (11pp), doi:10.1088/1748-6041/9/1/015007, IF=2.923

18.Qing Lin, Liqin Ling, Ling Guo, Jinjie Zhang, Tao Gong, Xun Sun, Zhirong Zhang*. Molecular property and intestinal absorption characteristics of imperialine in vitro and in situ. Acta Pharmacol Sinca, 2015;36:863-873. doi:10.1038/aps. 2015.27, IF=2.912

19.张志荣主编,十二五普通高等教育本科国家级规划教材、全国高等学校药学类规划教材《药剂学》(第二版),高等教育出版社,2014,北京。

 

2014--2015年参加国内外重要学术会议

1. 2014.11.01. 生物药物研发与创新青年学者高峰论坛。南京。大会特邀报告。题目:生物大分子药物体内高效递送系统研究策略。

2. 2015.6.23. 首届成都精准医学国际论坛---机遇与挑战。成都。大会特邀报告。题目:小分子导向的肾靶向递药系统研究。

  

Professor Zhi-Rong Zhang (Ph.D)

Lab: Key Lab of Drug Targeting and Drug Delivery Systems, West China School of Phamaceutical Sciences, Sichuan University

Mail Address: No.17, Section 3, South Renmin Road, Chengdu

Telephone/Fax: +86 (28) 85501566, +86 (28) 85501615

Email: zrzzl@vip.sina.com

 

Biography

- 1982.01. Graduated from Sichuan Medical College and awarded B.S. degree.

- 1982.011988.08. Assistant and Lecturer, The Department of Instumental Analysis, School of Phamaceutical Sciences, West China University of Medical Sciences.

- 1993.07. Graduated from West China University of Medical Science and awarded Phamaceutics PhD.

- 1993.12. Appointed as associated professor in the field of Pharmaceutics, School of Phamaceutical Sciences, West China University of Medical Sciences.

- 1997.09. Appointed as full professor in the field of PharmaceuticsSchool of Phamaceutical Sciences, West China University of Medical Sciences.

- 1998.01. Hired as doctoral supervisor.

- 1999.01. Nominated as the dean of the School of Phamaceutical Sciences, West China University of Medical Sciencesdoubling the director of Institute Materia Medicia.

- 1999. Sponsored by the National Distinguished Youth Scientific Fund.

- 1999. Selected to be a member of Class I & II in Hundreds and Thousands of Talents Project established by Chinese government.

- 2013. Elected as a member of Expert Consultation Group in the field of Health Sciences, National Basic Research Program of China (973 Program).

 

Current Positions

- Professor of Pharmaceutics.

- Dean of West China School of Phamaceutical Sciences , Sichuan University.

- Director of Key Lab of Drug Targeting and Drug Delivery Systems, Ministry of Education.

 

Memberships of Committees and Professional Bodies

- Member of Academic Degrees Committee of the State Council of China(20052015).

- Member of Chinese Pharmacopoeia Commission and Director of Pharmaceutical adjutants & Drug packaging materials of Chinese Pharmacopoeia Commission.

- Member of Expert Consultation Group in the field of Health Sciences, National Basic Research Program of China (973 Program).

- Member of Review Expertise Group of National Natural Science Foundation of China (NSFC).

- Director of Editorial board of pharmaceutical textbooks for national advanced medical colleges, Science Publishing House.

- Deputy Director of the Review Committee of pharmaceutical textbooks for national advanced colleges, People's Health Publishing House.

- Vice Chairman of Pharmaceutical Education Research Association, China Higher Medical Education Association

- Editor-in-Chief of West China Journal of Pharmaceutical SciencesandJournal of Chinese Pharmaceutics;

-Deputy Editor-in-Chief of "Chinese Traditional and Herbal Drugs" and "Chinese Pharmaceutical Yearbook";

- Editor of a dozen journals such as Acta Pharmaceutica Sinica, Chinese Pharmaceutical Journal, Chinese Journal of Antibiotics, Chinese Journal of Pharmaceuticals and Asia Journal of Pharmaceutical Sciences.

 

Research Orientation

- Drug Targeting and Drug Delivery System.

 

Research Achievements and Students Development

Prof. Zhang’s group has done a lot of valuable work in the development of drug delivery system (DDS), especially in targeting DDS and new drug development. Over the last decade, he was in charge of more than 20 projects, including grants from National Distinguished Youth Scientific Fund, National Natural Science Foundation, National High-Tech Research and Development Project (863 Project), National “Eleventh Five-Year” High-Tech fundamental research on key novel drug discovery,  and another 10 research projects from Ministry of Education and Sichuan province. 

Prof. Zhang maintains an active research group. He has successfully supervised 18 post doctors, 52 PhD students and 69 graduate students, and has contributed to chapters of 12 monographs and books. The published academic journal papers are more than 300 pieces, with over 118 of them in SCI journals. 10 new drugs have been development with his major or lesser contribution. 14 Chinese patents have been applied, of which 11 were granted. 

Prof. Zhang has awarded the First Prize of Sichuan Provincial Science and Technology Improvement Prize for 3 times, the Second Prize for 2 times and the Third Prize for 3 times. Furthermore, a Third Prize of Science and Technology Improvement Prize of Ministry of Education was awarded.

  

Current Research Projects

1.The study of brain-targeting drug delivery system oriented by small molecular straight-chain tertiary amine derivatives. Major Project of  the National Natural Science Foundation of PR China (Approval Number: 81130060) 2012.012016.12; 2,600,000 RMB.

2.Technique Platform Construction of Novel Preparation and Novel Drug Delivery System Meet for GLP Technique Platform Construction of Drug Targeting Delivery System and Novel Preparation. National “Twelfth Five-Year” High-Tech fundamental research on Key Novel Drug Discovery, Major National Science and Technology Projects (Approval Number: 2011ZX09310-002; Project Number: 2012ZX09304004001) 2012.012015.12; 2,680,000 RMB.

3.Key Techniques of Engineered Brain Tumor Targeting Nanomedicine Preparation. National Basic Research Program of China (973 Program) (Approval Number: 2013CB932504 ); 2013.12017.12;  2,690,000 RMB.

4. Study of pancreas and lung double-organ targeted drug delivery system for acute pancreatitis. The National Natural Science Foundation of PR China (Approval Number: 81473169) 2015.012018.12; 1,100,000 RMB.

5. Foundation on Application of Novel Drug Formulations and Preparations, Project of ChongQing Yaoyou Pharmaceutical Co., Ltd. (20102019) 10,000,000 RMB.

 

Selected Publications (20142015)

1. Xiawei Wei*, Bin Shao, Zhiyao He, Tinghong Ye, Min Luo, Yaxiong Sang, Xiao Liang, Wei Wang, Shuntao Luo, Shengyong Yang, Changyang Gong, Maling Gou, Hongxing Deng, Yinglan Zhao, Hanshuo Yang, Chengjian Zhao, Li Yang, Zhiyong Qian, Xun Sun, Jiahuai Han, Chengyu Jiang , Shuang Zhang, Min Wu, Zhirong Zhang*. Cationic Nanocarriers Induce Cell Necrosis through Impairment of Na+/K+-ATPase and Cause Subsequent Inflammatory Response. Cell Research, 2015; 25:1-17. doi:10.1038/cr2015.9, IF=12.413.

2.Jianbo Li*, Jinjie Zhang*, Yao Fu, Xun Sun, Tao Gong, Zhirong Zhang**. Dual-specific targeting therapy mediated by a phenolic propanediamine moiety for local and systemic complications of acute pancreatitis. Journal of Controlled Release2015;212:19-29. IF=7.705

3. Ting Zhang, Qiang Peng, Fenying San, Mengxin Wang, Wenqi Wu, Tao Gong*, Zhirong Zhang*. Sustained delivery of peptides and proteins by high content phospholipids-based phase separation gel. Biomaterials, 2015;45:1-9. IF=8.557.

4. Qi Wang, Peifeng Liu, Ying Sun, Tao Gong, Mingjie Zhu, Xun Sun, Zhirong Zhang*,Yourong Duan*. Preparation and properties of biocompatible PS-PEG/ Calcium phosphate nanospheres. Nanotoxicology, DOI:10.3109/17435390.2014. 911381. IF=7.336

5. Cheng Yan*; Zhu Biyue; Deng Yue; Zhang Zhirong*. In Vivo Detection of Cerebral Amyloid Fibrils with Smart DCM-Based Fluorescence Probe. Analytical Chemistry, 2015;87(9):4781-4787. doi: 10.1021/acs.analchem.5b00017. IF=5.825.

6.Yanping Li, Yangyang Zhou, Jiang, Jiayu; Xinyi Wang, Yao Fu, Tao Gong, Xun Sun, Zhirong Zhang*. Brain-targeting mechanism of dexibuprofen prodrugs modified with ethanolamine-related structures. Journal of Cerebral Blood Flow and Metabolism. 2015 00,1-10,doi:10.1038/jcbfm.2015.160, IF=5.407.

7. Xinyi Wang, Jianbo Li, Chaoqun Xu, Yanping Li, Tao Gong, Xun Sun, Yao Fu, Qin He, Zhirong Zhang*. Scopine as a novel brain-targeting moiety enhances the brain uptake of chlorambucil. Bioconjugate Chemistry, 2014,doi:10.1021/bc5004108,  IF=4.821.

8. Yuxuan Zhu, Xun Sun, Tao Gong, Qin He, Zhirong Zhang*. Antioxidant and antiapoptotic effects of 1,1'-(biphenyl-4,4'-diyl)-bis(3- (dimethylamino)-propan -1-one) protect PC12 cells from Aβ-induced injury. Molecular Pharmaceutics. 2014,11,428-435 . IF=4.787

9. Yanping Li; Yangyang Zhou; Bowen Qi; Gong Tao; Xun Sun; Yao Fu; Zhi-Rong Zhang*. Brain-specific delivery of dopamine mediated by N,N-dimethyl amino group for the treatment of Parkinson’s disease. Molecular Pharmaceutics. 2014, doi.org/10.1021/mp500352pl. IF=4.787.

10.Xiaohong Wang, Menghua Xiong, Yingchun Zeng, Xun Sun, Tao Gong, Zhirong Zhang*. A new conjugate: MGC in attenuating renal Ischemia/Reperfusion Injury. Molecular Pharmaceutics. 2014, doi.org/10.1021/mp500282g, IF=4.787.

11.Jingjie Zhang, Tao Gong*, Zhirong Zhang*. Mechanism of enhanced oral absorption of morin by phospholipid complex based self-nanoemulsifying drug delivery system. Molecular Pharmaceutics. doi.10.1021/mp5005806, IF=4.787

12.Xu Song, Qing Lin, Ling Guo, Yao Fu, Jianfeng HanHuan Ke, Xun Sun, Tao Gong*, Zhirong Zhang*. Rifampicin loaded mannosylated cationic nanostructured lipid carriers for dual-targeting to alveolar macrophages. Pharmaceutical Resaerch. 2014,doi:10. 1007/s11095-014-1572-3,IF=3.952.

13.Jingxin Mo, Lee Yong Lim* and Zhirong Zhang*. L-carnitine Ester of Prednisolone: Pharmacokinetic and pharmacodynamic evaluation of a Type I Prodrug. International Journal Pharmaceutics. 2014;475:e123-e129. IF=3.785.

14.Qin Zhang, Yao Fu, Renhe Liu, Tao Gong, Xun Sun, Zhi-Rong Zhang*. Renal-specific delivery of Prednisolone-folate conjugates for renal ischemia/ reperfusion injury. RSC Advanceds, 2014(4):5082850831. IF=3.708.

15.Man Li, Zhen Liang, Xun Sun, Tao Gong*, Zhirong Zhang*. A Polymeric Prodrug of 5-Fluorouracil-1-Acetic Acid Using a Multi-Hydroxyl Polyethylene Glycol Derivative as the Drug Carrier. Plos One, 2014,9(11):e112888. IF=3.534.

16.Peng Zhou, Xun Sun, Tao Gong, Zhirong Zhang*, Ling Zhang*. Conjugating glucosamine to triptolide to enhance its protective effect against renal ischemia- reperfusion injury and reduce its toxicity. Journal of drug targeting2014; 22(3): 200-210.IF=2.723.

17.Qi Wang, Pei Liu, Peifeng Liu, Tao Gong, Suming Li, Yourong Duan*, Zhirong Zhang*. Preparation, blood coagulation and cell compatibility evaluation of chitosan-graft-polylactide copolymers. Biomedical Materials, 9(2014)015007 (11pp), doi:10.1088/1748-6041/9/1/015007, IF=2.923

18.Qing Lin, Liqin Ling, Ling Guo, Jinjie Zhang, Tao Gong, Xun Sun, Zhirong Zhang*. Molecular property and intestinal absorption characteristics of imperialine in vitro and in situ. Acta Pharmacol Sinca, 2015;36:863-873. doi:10.1038/aps. 2015.27, IF=2.912

19.Editor-in-Chief : The textbook of undergraduate,PharmaceuticsSecond  Edition, Higher Education Press of R.P.China,2014,Beijing.

 

International academic conference presentations (2014-2015)

1. 2014.11.01. Young Investigator Summit Forum on Development and Innovation of Biopharmaceutics. Nanjing. Invited talks. Title:Efficient Strategies for in vivo Biomacromolecule Delivery".

2. 2015.6.23. The 1st International Forum on Precision Medicine Opportunities and Challenges. Chengdu. Invited talks. Title: Small Molecule-mediated Renal- targeted Drug Delivery Systems.

 

 



  编辑:四川大学华西药学院
上一篇: 黄园 教授 (博士生导师)
相关新闻
 
    CopyRight © 2005-2017 四川大学华西药学院 版权所有
    地址:四川省成都市人民南路三段17号  联系电话:028-85501628  传真:028-85501628  邮编:610041  邮箱:xyxban@163.com