今天是:2017年5月26日 星期五 农历五月初一
余蓉 教授 (博士生导师)
作者:佚名  来源:  发布时间:2016年02月23日  点击/评论:25501/0

余蓉 教授 (博士生导师)

单位 四川大学华西药学院

通信地址 四川省成都市人民南路3段17号

邮政编码 610041

电话/传真 (028)85503012

E-mail: yurong@scu.edu.cn

简历

 1982.6 在华西医科大学药学专业获得理科学士学位,2004~2007年在职在中国药科大学学习获得微生物与生化药学专业博士学位。1983.6~1984.6 中国协和医科大学&中国医学科学院学习, 1982.7~1998.6 中国协和医科大学&中国医学科学院输血研究所任实习研究员、助理研究员、副研究员、研究员。200.3-2007.8 国家公派高级研究学者赴美留学。1999年4月至今,四川大学华西药学院任教,博士生及硕士生导师。担任中国药学会生化与生物技术药物专业委员会委员、中国工业生化与分子生物学分会理事、四川省药学会药物化学专业委员会委员等,还兼任《药物生物技术》、《药品与食品》、《中国输血杂志》等专业学术杂志的编委,主编或参编全国高等院校药学专业教材(专著)近10部,为四川省有突出贡献的优秀专家和科技部、卫生部、 教育部同行评议专家。

研究领域与研究方向

研究领域 生物技术与生物新药

研究方向 1. 基因工程药物的研究

          2. 天然生化药物(包括微生物药物)的研究

          3. 蛋白质工程药物的设计

主要研究课题及成果

1. 新型凝血酶原复合物的研究 中国医学科学院科研基金0400603 主持人

2. 系列新型(药物)分子模板吸收树脂的研制及应用 科技部创新基金06C26215100476第二负责人

3. 免疫脂质体介导一氧化氮合酶基因靶向给药系统的研究 国家自然科学基金 30070900) 第四主研

4. 科研上先后主持承担或作为主研人员参与了十多项科研项目(课题)的研究工作(其中有国家自然科学基金课题2项,卫生部科学基金课题2项,中国医学科学院科学基金课题3项,省级科学基金课题4项)。曾获得四川省科技进步一等奖、二等奖各一项和中国医学科学院科技进步三等奖二项。在国内外专业期刊杂志和学术会议上发表学术论文80余篇。获得中国发明专利3项,另外还有3项发明专利申请已被中国专利局受理已公开。

代表论著

1. 余蓉,张贵峰,高玲等 液相色谱-串联质谱法研究重组水蛭素12肽与瑞替普酶融合蛋白(HV12p-rPA)的一级结构 药学学报2008,43(7):737-742

2. 杨俐 张涛 余蓉 等 固态发酵贵州绿僵菌产壳聚糖酶的亲和层析纯化及其性质研究 四川大学学报(医学版) 2007;4:713

3. LI Tao, YU Rong Yang Zhengming,et al A Method for Purification and Viral Inactivation of Human Placenta Hemoglobin Artificial Cells BLOOD SUBSTITUTES & BIOTECHNOLOGY (SCI) 2006,34,( 2):167

4. 李涛, 杨成民, 余蓉, 等 人脐带血血红蛋白的分离纯化与病毒灭活研究 生物医学工程学杂志 (EI收录) 2006;23(3)∶640~644

5. 余蓉,韦利军,李灵玲,等 抗凝、溶栓双功能水蛭素12肽-瑞替普酶融合蛋白的模拟、构建与表达 药物生物技术 2005;12(3)190

6. 余蓉 吴梧桐,李灵玲 合理的设计与工程化蛋白质药物 药物生物技术 2005;12(3)190

7. 余蓉. 李晓红,杨继虞 重组人胰岛素的制备——下游纯化工艺的研究 生物医学工程学杂志 2004;21(5):805

8. 李晓红; 余蓉; 曾蓉,等 Enhanced Expression of (His)6 –Arg –Arg-human Proinsulin 药物生物技术 2003;(10)3:144

9. 余蓉; 李晓红; 祁辉,等; A Batch Procedure for Preparation of Factor Ⅸ Complex Concentrates 中国现代应用药学
2003,20(6):406

10. 余蓉; 邬杨斌 等;凝血Ⅸ因子复合物制品在鼠非停滞模型上潜在致血栓性的评价 中国药理与毒理学杂志 2002,16(2):206

编写教材及专著

1. 生物技术制药概论(1版,2 版) 中国医药科技出版社,2002,2009(参编)

2. 生物化学(5版,6版,药学专业)人民卫生出版社, 2004,,2007 (参编)

3. 生物技术制药 人民卫生出版社, 2007 (参编)

4. 生物制药工艺学 人民卫生出版社,2007 (参编)

5. 实用生物制药学 人民卫生出版社,2007 (参编)

6. 现代天然产物化学 科学出版社 2009 (参编)

7. 药学概论 科学出版社 2009 (主编)

8. 生物工程 中国医药科技出版社 2009 (参编)

 

Profossor RONG YU (Ph.D)

Recent research interests
I am mainly engaged in the structure, function and drug discovery studies from nature macromolecule and biopharmaceuticals manufactured by biotechnology methods.

1. DNA recombinant medicine 
This study relates to the development of various recombinant DNA technology and high performance purification scheme for biopharmaceuticals. These projects usually involve construction, expression and purification of novel recombinant medicine. The gene recombinant separation technique makes a key success in modern biopharmaceutical. The techniques of separation and purification these proteins take important position in gene engineering.

2. Biochemical medicine and Microbial medicine 
The objective of this project is to develop fast and efficient large scale biochemical isolation technology that will enable a high recovery of products. Process integration will be performed by combination of cell disruption, membrane separation and various chromatography.

3.The protein engineering therapeutics design
This research is aimed to develop new biotech drugs. The protein engineering technique has become an effective stratagem to improve variant properties of therapeutic proteins, including enhanced thermo stability, bioactive specify, targeted delivery, decrease in immunity and improving pharmacokinetics. Rational protein engineering is according to the hypothesis driven manipulation of protein sequence and/or composition. Biopharmaceuticals are now entering the third stage of product development in which true lead optimization to modulate the physical, chemical and biological properties of proteins is possible. Rational optimization of proteins as drugs makes a key success in modern biopharmaceutical. The controlled manipulation of the physical, chemical and biological properties of proteins enabled by structure-based simulation is now being used to refine established rational engineering approaches and to advance new strategies. These methods provide clear, hypothesis driven routes to solve problems that plague many proteins and to create novel mechanisms of action. An increasing number of engineered protein therapeutics are currently being developed, tested in clinical trials and marketed for use.

Main Publications

1. YU Rong; ZHANG Gui-feng; GAO Ling; SU Zhi-guo; WU Wu-tong. Primary structure determination of hirudin and reteplase fusion protein by LC/ESI-MS/MS spectrometry. Acta Pharmaceutica Sinica 2008,43(7):737

2. GAO Ling, YU Rong* RP-HPLC Purification for Primary Structure Confirmation of 12 Peptides of Hirudin and Reteplase Fusion Protein. Food and Drug 2008,10(1):8

3. YU Rong; WEI Li-jun1; LI Ling-ling; GAO Ling; WU Wu-tong.Simulation,Construction and Expression of A Fusion Protein Made of 12 Peptides of Hirudin and Reteplase Pharmaceutical Biotechnology, 2007,14(3):168

4. YANG Li; ZHANG Tao; LI Xiao-hong; YU Rong Purification of a Novel Chitosanase from Metarhizium guizhouense in Solid-state Fermentation with Affinity Chromatography. Journal of Sichuan University(Medical Science Edition) 2007;4:713

5. Li Tao, Zhang Honghu, Wang Hong, Yu Rong, Yang Chengmin, ,Purification and Viral Inactivation of Hemoglobin from Human Placenta Blood. J Biomed Eng 2006;23(3)∶640~644

6.Li Tao, Yu Rong et al. A Method for Purification and Viral Inactivation of Human Placenta Hemog- lobin Artificial Cells BLOOD SUBSTITUTES & BIOTECHNOLOGY 2006,34( 2):175

7.Yu Rong,Wu Wu-tong, Li Ling-ling Rational design and engineering of therapeutic proteins Pharmaceutical biotechnology 2005;12(6): 401

8. Li Xiao-hong, Yu Rong, Yang Ji-yu. Preparation and analysis of Monocomponent Insulin Journal of Sichuan University (Natural Science Edition) 2005;42(1):175

9. Yu Rong, Qi Hui, Zhang Tao, et al. Preliminary studies on in vitro and in vivo thrombolytic activities of thrombolytic enzyme from an induced Bacillus Subtills Strain. Journal of Sichuan University (Medical Science Edition) 2005;36(1)93-96

10. Yu Rong, Li Xiao-hong,Yang Ji-yu. Preparation of recombinant human insulin---study of downstream process. Journal of Biomedical Engineering 2004;21(5):805

11. Yu Rong, Zhou Rui, Yang Ji-yu. Preparation of α-tertbutyl threonine tertbutylester and determination of its purity. Chemical Research and Application 2004;(16)5:695

12. Li Xiu-ling, Yu Rong, Yang Ji-yu et al. Improve on preparation of high pure haemachrome. Journal of Sichuan University (Medical Science Edition) 2004;35(5):738

13. Zhou Rui, Yu Rong, Yang Ji-yu. Rapid preparation of immobilized trypsin Biotechinology;2004,14(3):26

14. Zhang Tao, Yu Rong, Li Ling-ling. Preliminary study on Chitosan Isolatated from Rhizopus Japonicus. Food and Fermentation industries 2004,30(12):66

15. Li Xiu-ling, Yu Rong, He Ling. Synthesis of metal hematoporphyrins and their activity as mimicry enzyme. West China Journal of Pharmaceutical sciences 2004,19(5):342

16. Li Xiao-hong, Yu Rong, Yang Ji-yu. Enhanced Expression of (His)6 –Arg –Arg-human Proinsulin. Pharmaceutical 
biotechnology 2003;(10)3:144

17. Yu Rong, Li Liao-hong, Qi Hui. A Batch Procedure for Preparation of Factor Ⅸ Coplex Concentrates. Chinese 
Journal of Modern Applied Pharmacy 2003,20(6):406

18. Yu Rong, Wu Yang-bin,Du Jun-rong, et al. Evaluation of factor Ⅸ complex concentrates in a nonstasis ret model
of thrombogenicity. Chinese Journal of Pharmacology and Toxicology 2002,16(2):20 

 

 


 

 



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