肖友财 副教授（硕导）
单位：四川大学华西药学院药物化学系
通讯地址：成都市人民南路三段十七号药学科技楼204
Mobile Phone：+86 13550321845
E-mail：xiaoliguo1987@scu.edu.cn
教育及工作经历
2005.09-2009.06 四川大学华西药学院，理学学士
2009.09-2014.06 四川大学华西药学院，药物化学 博士(导师：陈应春教授)
2014.10-2015.10 瑞典皇家理工学院(KTH)博士后(导师：Cristina Moberg教授)
2015.12-2017.01 美国德雷塞尔大学 博士后(导师: Joseph. Salvino教授)
2017.02-2018.06 美国Wistar研究所 博士后, (导师：Joseph. Salvino教授)
2018.07-至今 四川大学华西药学院，药物化学系，特聘副研究员
研究方向
含硼小分子化合物因其独特的化学性质在药物设计方面受到很大关注，在抗炎、抗菌、抗肿瘤等方面正扮演愈发重要的角色。通过有机合成新方法构建结构新颖的含硼药物分子，优化该类分子的成药性，结合计算机辅助药物设计等新技术开展磷酸酶等“难成药靶点”的设计合成以及生物活性研究，包括：
1. 含硼小分子化合物的抗肿瘤以及抗耐药菌药物化学研究
2. 磷酸酯酶抑制剂的设计合成及生物学研究
3. PROTAC等靶向蛋白降解药物的设计及生物机制研究
主讲课程
1. 药物化学，药物化学实验，高等药物化学实验
2. 创新药物研究与评价
3. 新药技术与药品监管
科研项目
1. 四川大学引进人才科研启动经费资助项目 "蛋白靶向嵌合分子技术用于化学敲出MEK激酶治疗恶性黑色素瘤的研究”2018.07-2021.07
2. “基于苯并硼酸酯优势骨架的新型广谱碳青酶烯酶抑制剂的设计、合成及生物活性评价” 国家自然科学青年基金, 20907072，2020.01-2022.12
3. “三苯基膦阳离子载体-抗菌分子偶联物的设计、合成以及抗菌活性研究” 四川省自然科学基金面上项目, 2022NSFSC0619, 2022.01-2023.12
4. 四川省“高端人才”青年人才项目,川特聘第1368，2020.03-2023.03
近三年代表性论文
1. Clare M Adams, Ramkrishna Mitra, You-Cai Xiao, Peter Michener, Juan Palazzo, Allen Chao , Jitendra Gour, Joel Cassel, Joseph M Salvino*, Christine M Eischen*.“Targeted MDM2 degradation reveals a new vulnerability for p53-inactivated triple-negative breast cancer”, Cancer. Discovery. 2023, 13, 1210–1229. (IF:28.2, 一区)
2. Guo-Qing Liang, Ji Deng, Cheng-Xu Wu, Wen-Jing Li, Yu-Fei Hu, Yu-Qian Song, Xiao-Chen Yin, Qin He, You-Cai Xiao*, Guo-Bo Li*. “Design, synthesis and biological evaluation of boron-containing β-lactamase inhibitors: Closed-loop education experiences in an undergraduate medicinal chemistry course”, J. Chem. Educ. 2023, 100, 803–810. (IF:3.0, 二区)
3. Hong-Jiao He, Rui-Qi Wang, Lin-Xi Wan, Li-Yan Zhou, Hong-Yan Li, Guo-Bo Li, You-Cai Xiao*, Fen-Er Chen*. “Organocatalytic asymmetric Morita-Baylis-Hillman reaction of isatins with vinyl sulfones”, J. Org. Chem. 2023, 88, 3802–3807. (IF:3.6, 二区)
4. Yuan Zhou, Tong Xiong, Li-Yan Zhou, Hong-Yan Li, You-Cai Xiao*, Fen-Er Chen*.“Diastereo- and enantioselective synthesis of borylated 3-hydroxyoxindoles by addition of gem-diborylalkanes to isatins”, Org. Lett. 2022, 24, 791–79. (IF:6.1, 一区)
5. Hui-Jing Wang, Yang-Yang Zhong, You-Cai Xiao*, Fen-Er Chen*. “Chemical and chemoenzymatic stereoselective synthesis of β-nucleosides and their analogues”, Org. Chem. Front. 2022, 9, 1719–1741. (IF:5.4, 一区)
6. Zhao-Feng Li, Hong-Jiao He, Rong-Hui Wang, Li-Yan Zhou, You-Cai Xiao*, Fen-Er Chen*. “Copper-catalyzed asymmetric alkynylation of pyrazole-4,5-diones using chloramphenicol base-derived hydroxyl oxazoline ligands”, Org. Chem. Front. 2022, 9, 2792–2796. (IF:5.4, 一区).
7. Xiao-Pan Chen, Jin-Xin Liu, Hong-Yan Li, You-Cai Xiao*, Fen-Er Chen*. “Asymmetric synthesis of spirooxazolidinone oxindoles by the thiourea-catalyzed Aldol reaction of 2-isocyanatomalonate diesters”, Adv. Synth. Catal. 2022, 364, 2067–207. (IF:5.9, 二区)
8. You-Cai Xiao*, Jun-Lin Yu, Qing-Qing Dai, Gen Li, and Guo-Bo Li*. “Targeting metalloenzymes by boron-containing metal-binding pharmacophores”, J. Med. Chem. 2021, 64, 17706–17727. (IF:7.3, 一区)
9. You-Cai Xiao, Xiao-Pan Chen, Ji Deng, Yu-Hang Yan, Kai-Rong Zhu, Gen Li, Jun-Lin Yu, Jürgen Brem, Fener Chen, Christopher J. Schofield*, Guo-Bo Li*. “Design and enantioselective synthesis of 3-(α-acrylic acid) benzoxaboroles to combat carbapenemase resistance”, Chem. Commun, 2021, 57, 7709–7712.
10. Yu-Hang Yan, Zhao-Feng Li, Xiang-Li Ning, Ji Deng, Jun-Lin Yu, Yubin Luo, Zhenling Wang, Guo Li, Guo-Bo Li*, You-Cai Xiao*. “Discovery of 3-aryl substituted benzoxaboroles as broad-spectrum inhibitors of serine- and metallo-β-lactamases”, Bioorg. Med. Chem. Lett. 2021, 41, 127956.
11. Rong-Hui Wang, Ya-Ling Li, Hong-Jiao He, You-Cai Xiao*, Fen-Er Chen*. “Catalytic asymmetric addition of diorganozinc reagents to pyrazole-4,5-diones and indoline-2,3-diones”, Chem. Eur. J. 2021, 23, 4302–4306.
12. Marco De Dominici1, Patrizia Porazzi1, You-Cai Xiao, Allen Chao, Hsin-Yao Tang, Gaurav Kumar, Paolo Fortina, Orietta Spinelli, Alessandro Rambaldi, Luke F Peterson, Svetlana Petruk, Camilla Barletta, Alexander Mazo, Gino Cingolani, Joseph M Salvino*, Bruno Calabretta*, “Selective inhibition of Ph-positive ALL cell growth through kinase-dependent and -independent effects by CDK6-specific PROTACs”, Blood. 2020, 135, 1560–1573 (IF:20.3, 一区)
13. Jeremy D. Osko, Nicholas J. Porter, Poli Adi Narayana Reddy, You-Cai Xiao, Johanna Rokka, Manfred Jung, Jacob M. Hooker, Joseph M. Salvino, and David W. Christianson*, “Exploring structural determinants of inhibitor affinity and selectivity in complexes with histone deacetylase 6”, J. Med. Chem. 2020, 63, 295–308. (IF:7.3, 一区)
