高璐 副教授（硕士生导师）
联系方式
通讯地址：成都市人民南路三段17# 四川大学华西药学院，610041
电子邮箱E-mail: lugao@scu.edu.cn
教育背景及工作经历
2005-2009 四川大学华西药学院，本科。
2009-2014 四川大学华西药学院药物化学专业硕博连读，师从宋振雷教授。
2014-2016 四川大学华西药学院，讲师。
2016-至今 四川大学华西药学院，副教授。
科研项目
1、国家自然科学基金青年基金：“手性硅烷及手性硅替代活性分子的合成及应用研究” 2016-2018，主持
2、川大-泸州项目：“甾体类药物合成关键技术研究”2024-2026，主持
3、川大-泸州项目：“单唾液酸四己糖神经节苷脂钠的精制工艺”2017-2018，主持
4、四川大学青年教师启动基金：“手性有机硅烷的合成、性能及硅替代药物合成研究” 2015-2016，主持
研究方向
手性硅烷及含硅试剂的合成及应用研究
近五年论文
1. Wang, W. S.; Gao, L.*; Song, Z. L.*; Synthetic Approaches for the Construction of Five- and Six-Membered Silaazacycles. Synthesis 2022, 54, 2749-2764.
2. Li, Y.; Hu, T. B.; Gao, L.*; Song, Z. L.*; Addition/Substitution Approach of TsNHCH2SiMe2CH2Cl with Isocyanates or Isothiocyanates To Construct 1,3,5-Diazasilinan-2-ones or 1,3,5-Thiazasilinan-2-imines. Synthesis 2022, 54, 2585-2594.
3. Zhou, S.; Tu, X. Y.; He, Y. H.; Gao, L.*; Song, Z. L.* Ring Rearrangement of 1,3-Azasilinyl-4-epoxides to Synthesize 2-Silamorpolines by a Si−C Bond Migration/Oxidation Process. Eur. J. Org. Chem. 2022, e202200766.
4. Gan, Z. B.; Cui, D. Y.; Zhang, H. Y.; Feng, Y.; Huang, L. Y.; Gui, Y. Y.; Gao, L.*; Song, Z. L.*; Trityl Cation-Catalyzed Hosomi-Sakurai Reaction of Allylsilane with β,γ-Unsaturated α-Ketoester to Form γ,γ-Disubstituted α-Ketoesters. Molecules 2022, 27(15), 4730.
5. Chen, Y.; Song, X. Y.; Gao, L.*; Song, Z. L.*; Intramolecular Sakurai Allylation of Geminal Bis(silyl) Enamide with Indolenine. A Diastereoselective Cyclization To Form Functionalized Hexahydropyrido[3,4-b]Indole. Org. Lett. 2021, 23(1), 124-128.
6. Chu, Z. W.; Tong, R. Q.; Yang, Y. F.; Song, X. Y.; Hu, T. B.; Fan, Y.; Zhao, C.; Gao, L.*; Song, Z. L.*; Diverse synthesis of the C ring fragment of bryostatins via Zn/Cu-promoted conjugate addition of α-hydroxy iodide with enone. Chin. Chem. Lett. 2021, 32, 1-4.
7. Hu, T. B.; Huang, L. Y.; Gao, L.*; Song, Z. L.*; Synthesis of unsymmetrical diarylmethanols via C–Si bond bifunctionalization enabled by sequential [1,4]-Csp2 to O-silyl migration. Org. Chem. Front. 2020, 7, 543-547.
8. Liu, S. F.; Yang, Y. F.; Gao, L.*; Song, Z. L.*; ArNMeCH(SiMe3)2: a useful precursor of formal α-aminoalkyl diradicals in visible-light-mediated homo- and hetero-diaddition with alkenes. Chem. Commun. 2020, 56 (54), 7487-7490.
9. Xiao, P. H.; Gao, L.*; Song, Z. L.*; Recent Progress in the Transition-Metal-Catalyzed Activation of Si−Si Bonds To Form C−Si Bonds. Chem. – Eur. J. 2019, 25(10), 2407-2422.
10. Wang, K.; Li, L. J.; Hu, T. B.; Gao, L.*; Song, Z. L.*; One-Pot Twofold Unsymmetrical C–Si Bond 2,6-Bifunctionalization of Arenes via Sequential [1,4]-Csp2 to O-Silyl Migration. J. Org. Chem. 2019, 84, 12583-12595.
11. Wu, Y.; Chen, H.; Yang, W. Y.; Fan, Y.; Gao, L.*; Su, Z. S.; Hu, C. W.; Song, Z. L.*; Asymmetric retro-[1,4]-Brook rearrangement of 3-silyl allyloxysilanes via chirality transfer from silicon to carbon. RSC Adv. 2019, 9(45), 26209-26213.
编辑：四川大学华西药学院
