陈应春 教授 （博士生导师）
单位：四川大学华西药学院药物化学系
通讯地址：成都市人民南路三段十七号 四川大学华西药学院
电话/传真：（028）85502609
E-mail: ycchen@scu.edu.cn
简历
1990-1994天津南开大学化学系有机化学专业 本科
1994-1997华西医科大学药学院药物化学专业 硕士研究生
1998-2001中科院成都有机化学研究所有机化学专业 博士研究生
2001-2002中科院成都有机化学研究所 博士后研究
2002-2003香港大学化学系 博士后研究
2003- 四川大学华西药学院教授、博士生导师
研究内容
主要从事新型手性催化剂的设计、合成及不对称催化反应研究以及生理活性物质的设计、合成等方面的工作。重点在手性有机小分子以及金属配合物催化的不对称合成领域开展研究并获得了系列成果：1）在基于氢键活化的手性硫脲等催化剂的设计及其促进的不对称反应进行了多方面研究，建立了结构、功能多样的基于氢键活化的有机催化剂库，在多种不对称催化反应中实现了好的立体控制，发展了多种重要手性中间体、特别是非天然氨基酸的不对称合成方法。2）在手性伯、仲胺通过烯胺、二烯胺、三烯胺及亚胺盐机制催化饱和或不饱和醛和酮以及叔胺、叔膦等作为Lewis碱催化Morita-Baylis-Hillman产物碳酸酯的不对称转化反应等领域开展了系统的研究，在催化剂、催化机制及新型催化反应的设计等多方面进行了积极探索。3）致力于新颖的硫酚/手性胺、硫酚/手性相转移以及硫酚/有机膦等共催化体系的发展，实现了多类具挑战性的不对称反应的区域、化学以及立体选择性的高效调控。4）探索新型的Lewis碱/金属配合物协同催化体系，进一步拓展了叔膦/叔胺等Lewis碱催化的应用范围。5）建立发展基于金属钯p-Lewis碱配合物催化的新型反应途径。6）课题组发展了数十种多官能团、多手性中心化合物的合成新方法，建立数千个新型化合物库；通过计算机辅助和细胞筛选实验，发现多类新颖的抗肿瘤、抗肺纤维化等新结构物质，为进一步发现和设计新型生理活性手性化合物奠定坚实基础。
作为通讯作者已在Chem. Soc. Rev.、Acc. Chem. Res.、Nat. Chem.、J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Chem. Sci.、ACS Catal.等国内外学术期刊上发表SCI论文190余篇，总他引9000余次。参与《Cinchona Alkaloids in Synthesis & Catalysis: Ligands, Immobilization and Organocatalysis》、《Asymmetric Organocatalysis》、《Organocatalytic Ring-Forming Reactions》等英文专著章节的撰写工作。完成了包括国家Ⅰ类抗癌新药Cambretastatin A-4水溶性前药、国家Ⅰ类抗脓毒症新药KB甲烷磺酸盐等药物的合成研究（均进入临床研究）。
现主要研究课题
1.中国-波兰国际合作交流项目：路易斯碱催化芳香羰基化合物的不对称反应研究。（140万元，2019-2022）
2.国家自然科学基金重点项目：新型Lewis碱催化体系的发展及相关不对称反应研究。（300万元，2020-2024）
3.国家自然科学基金委创新群体项目。（2020-2024，参与）
4.重大研究计划（多层次手性物质的精准构筑）培育项目：钯作为π-Lewis碱催化缺电二烯及多烯的不对称反应研究。（70万元，2022-2024）
5.四川省科技计划重点研发项目：靶向热休克蛋白Hsp70异构的原创性小分子药物开发及对人头颈鳞癌细胞生长抑制的研究。（100万元，2022-2023）
获奖情况
1. 2007年 四川省第九届青年科技奖
2. 2007年 药明康德生命化学研究奖（三等）
3. 2011四川省有突出贡献的优秀专家
4. 2011年国家杰出青年科学基金
5.2012Thieme Journal Award
6.2012 Asia Core Program Lectureship Award
7.2013年全国百篇优秀博士学位论文指导教师
8. 2014年中国化学会青年手性化学奖
9. 2014年科技部科技创新人才推进计划青年领军人才
10. 2015年四川省卫生计生领军人才
11. 2016年科技部第二批高端人才青年领军人才
发表论文情况
2022年
1.Jian-Xiang Zhu, Zhi-Chao Chen,* Wei Du, and Ying-Chun Chen,* “Asymmetricauto-tandem palladium catalysisfor2,4-dienyl carbonates: Ligand-controlled divergent synthesis”,Angew. Chem. Int. Ed.2022,61, DOI:10.1002/anie.202200880.
2.Bao-Xin Liu, Ru-Jie Yan, Wei Du,* and Ying-Chun Chen,* “Solvent-regulated diastereodivergent [3+2] annulations of CF3-containing Morita−Baylis−Hillman carbonates with cyclic sulfonimines”,Chin. J. Chem.2022,40, DOI: 10.1002/cjoc.202200003.
3.Xing-Xing Yang, Xing-Liang Zhao, Qin Ouyang,* Wei Du,* and Ying-Chun Chen,* “Palladium-catalysed diastereodivergent inverse-electron-demand oxa-Diels-Alder reactions of in situ formed cyclopentadienones via ligand-control”,Org. Chem. Front.2022,9, DOI: 10.1039/D1QO01876K.
4.Ze-Liang He,Peng Chen,Zhi-Chao Chen,*Wei Du, and Ying-Chun Chen,* “Construction ofhydrodibenzo[b,d]furan frameworks from Morita-Baylis-Hillman carbonates of isatins andortho-hydroxy enones via palladium and Brønsted base relay catalysis”,Org. Lett.2022,24,100.
2021年
5.Xing-Xing Yang, Ru-Jie Yan, Guang-Yao Ran,Chen Chen, Jing-Fei Yue, Xiao Yan, Qin Ouyang,* Wei Du,* and Ying-Chun Chen,* “p-Lewis-base-catalyzed asymmetric vinylogous umpolung reactions of cyclopentadienones and tropone”,Angew. Chem. Int. Ed.2021,60, 26762.
6.Zhi Chen, Zhi-Chao Chen,* Wei Du, Ying-Chun Chen,* “Asymmetric [4 + 3] annulations for constructing divergent oxepane frameworks via cooperative tertiary amine/transition metal catalysis”,Org. Lett.2021,23, 8559.
7.Qing He, Lei Zhu,Zhen-Hong Yang,Bo Zhu, Qin Ouyang,* Wei Du,* and Ying-Chun Chen,* “Palladium-catalyzed modular and enantioselectivecis-difunctionalization of 1,3-enynes with imines and boronic reagents”,J. Am. Chem. Soc.2021,143, 17989.
8.Ru-Jie Yan, Bao-Xin Liu, Yuan Hu, Wei Du,* and Ying-Chun Chen,* “Generation of zwitterionic trifluoromethyl N-allylic ylides and use in switchable divergent annulations”,Chem. Commun.2021,57, 9056.
9.Yue Li, Peng Chen, Zhi-Chao Chen,* Wei Du, Qin Ouyang, Ying-Chun Chen,* “Palladium-catalysed oxidative nucleophilic allylation between alkenes and activated ketimines”,Org. Chem. Front.2021,8, 5418.
10.Yang Yang, Bo Zhu, Lei Zhu, Ying Jiang, Chun-Ling Guo, Jing Gu, Qin Ouyang,* Wei Du,* and Ying-Chun Chen,* “Combining palladium and ammonium halide catalysts for Morita-Baylis-Hillman carbonates of methyl vinyl ketone: from 1,4-carbodipoles to ion pairs”,Chem. Sci.2021,12, 11399.
11.Zhi Zhao, Xing-Xing Yang, Guang-Yao Ran, Qin Ouyang, Wei Du,* and Ying-Chun Chen,* “Ligand-controlled regiodivergent asymmetric [5 + 2] and [3 + 2] annulations of vinyl indoloxazolidones catalyzed by palladium”,Org. Lett.2021,23, 4791.
12.Zhen-Hong Yang, Peng Chen,Zhi-Chao Chen, Zhi Chen, Wei Du,* and Ying-Chun Chen,* “A double deprotonation strategy for cascade annulations of palladium-trimethylenemethanes and Morita-Baylis-Hillman carbonates to constructbicyclo[3.1.0]hexane frameworks”,Angew. Chem. Int. Ed.2021,60, 13913.
13.Ben-Xian Xiao, Bo Jiang,Ru-Jie Yan, Jian-Xiang Zhu, Ke Xie, Xin-Yue Gao, Qin Ouyang,* Wei Du,* and Ying-Chun Chen,* “Apalladium complex as an asymmetricπ-Lewis base catalyst for activating 1,3-dienes”,J. Am. Chem. Soc.2021,143, 4809.
14.Bao-Xin Liu, Ru-Jie Yan, Xiao-Xun Li, Wei Du,* and Ying-Chun Chen,* “Asymmetric [3+2] annulations of thioaurone and aurone derivatives for the construction ofspiroheterocycles”,Asian J. Org. Chem.2021,10, 784.
15.Zhi-Chao Chen, Wei Du, and Ying-Chun Chen,* “New amines and activation modes in asymmetric aminocatalysis”,Chin. J. Chem.2021,39, 1775.
16.Jian-Bin Lu, Chong-Hui Shi, Di Hu, Xin-Yue Gao, Zhi-Chao Chen,* Wei Du, and Ying-Chun Chen,* “Regioselectivity umpolung in asymmetric Diels-Alder reaction ofortho-formyl-substituted cinnamates and dienals via double aminocatalysis”,Org. Lett.2021,23, 145.
17.Yang Gao, Xue Song, Ru-Jie Yan, Wei Du, and Ying-Chun Chen,* “Asymmetric β,γ¢-regioselective [4+3] and [4+2] annulations ofa-vinylenals via cascade iminium ion−dienamine catalysis”,Org. Biomol. Chem.2021,19, 151.
2020年
18.Cui-Xia Hu, Lin Chen, Di Hu, Xue Song, Zhi-Chao Chen,* Wei Du, and Ying-Chun Chen,* “Construction ofenantioenriched 9H-fluorene frameworks via cascade reaction involving remote vinylogous dynamic kinetic resolution”,Org. Lett.2020,22, 8973.
19.Xue Song, Ru-Jie Yan, Wei Du,* and Ying-Chun Chen,* “Asymmetric dearomative cascade multiple functionalizations of activated N-alkylpyridinium and N-alkylquinolinium salts”,Org. Lett.2020,22, 7617.
20.Qing He, Zhen-Hong Yang, Jing Yang,* Wei Du, and Ying-Chun Chen,* “Enantioselective formal arylation of (7-aza)isatylidene malononitriles witha¢-alkylidene-2-cyclohexenones”,Adv. Synth. Catal.2020,362, 4438.
21.Shu-Yuan Liang, Bo Jiang,Ben-Xian Xiao, Zhi-Chao Chen, Wei Du, and Ying-Chun Chen,* “Phosphine catalyzed enantioselective cascade reaction initiated by intermolecular crossRauhut–Currier reaction of electron-deficientortho-formyl styrenes”,ChemCatChem2020,12, 5374.
22.Ying Jiang, Yang Yang,Qing He,Wei Du,* and Ying-Chun Chen,* “Asymmetric intramolecular Rauhut-Currier reaction and its desymmetric version via double thiol/phase-transfer catalysis”,J. Org. Chem.2020,85, 10760.
23.Chang-Jiang Xu, Wei Du,Łukasz Albrecht, and Ying-Chun Chen,* “Lewis basic amine-catalyzed aza-Michael reaction of indole- and pyrrole-3-carbaldehydes”,Synthesis2020,52, 2650.
24.Guang-Yao Ran, Chen Chen, Xing-Xing Yang,Zhi Zhao, Wei Du,* and Ying-Chun Chen,* “Cu(I)-catalyzed asymmetricα-allenylation of activated ketimines with 3-butynoates”,Org. Lett.2020,22, 4732.
25.Bo Jiang, Wei Du,*and Ying-Chun Chen,* “Modified cinchona alkaloid‐catalysed enantioselective [4 + 4] annulations of cyclobutenones and 1-azadienes”,Chem. Commun.2020,56,7257.
26.Ru-Jie Yan, Bao-Xin Liu, Ben-Xian Xiao, Wei Du, and Ying-Chun Chen,* “Asymmetric (4 + 3) and (4 + 1) annulations of isatin-derived Morita−Baylis−Hillman carbonates to construct diverse chiral heterocyclic frameworks”,Org. Lett.2020,22, 4240.
27.Peng Chen, Yue Li, Zhi-Chao Chen,* Wei Du, and Ying-Chun Chen,* “Pseudo-stereodivergent synthesis of enantioenriched tetrasubstituted alkenes via cascade 1,3-oxo-allylation/Cope rearrangement”,Angew. Chem. Int. Ed.2020,59, 7083.
28.Di Hu, Yang Gao, Xue Song, Wei Du, and Ying-Chun Chen,* “Asymmetric remote addition reactions of heterocycle-based dearomative dienamine or trienamine species to 1-azadienes: Application to construct chiral azocanes and azecanes”,Eur. J. Org. Chem.2020, 514.
29.Yang Yang, Ying Jiang, Wei Du, and Ying-Chun Chen,* “Asymmetric cross [10+2] cycloaddtions of 2-alkylidene-1-indanones and activated alkenes under phase-transfer catalysis”,Chem. Eur. J.2020,26, 1754.
30.Zhi-Chao Chen, Zhi Chen, Wei Du,* and Ying-Chun Chen,* “Transformations of modified Morita–Baylis–Hillman adducts from isatins catalyzed by Lewis bases”,Chem. Rec.2020,20, 541.
2019年
31.Peng-Fei Zheng, Rong Zeng, Kun Jiang, Hong-Wei Li, Ying Ye, Chao Mu, Li Shuai, Qin Ouyang,* Ying-Chun Chen,* “(3 + 1) Annulation/rearrangement cascade ofC,N-cyclic azomethine imines and 3-chlorooxindoles: Construction of hexahydroindeno[2,1-c]pyrazole spirooxindole frameworks”,Org. Lett.2019,21, 10052.
32.Xin-Yue Gao, Ru-Jie Yan, Ben-Xian Xiao, Wei Du,Łukasz Albrecht, and Ying-Chun Chen,* “Asymmetric formal vinylogous iminium ion activation for vinyl-substituted heteroaryl and aryl aldehydes”,Org. Lett.2019,21, 9628.
33.Ben-Xian Xiao, Chong-Hui Shi, Shu-Yuan Liang, Bo Jiang, Wei Du, and Ying-Chun Chen,*“Remote Friedel-Crafts reaction withα-heteroaryl-substituted cyclic ketones via HOMO-activation of Lewis bases”,Org. Lett.2019,21, 7554.
34.Zhi Zhou, Qing He, Ying Jiang, Qin Ouyang, Wei Du,* and Ying-Chun Chen,* “Double thiol-chiral Brønsted base catalysis: Asymmetric cross Rauhut-Currier reaction and sequential [4 + 2] annulation for assembly of different activated olefins”,Org. Lett.2019,21, 7184.
35.Zhi-Chao Chen, Zhi Chen, Zhen-Hong Yang,Li Guo, Wei Du,* and Ying-Chun Chen,* “Cooperativetertiary amine/chiral iridium complex catalyzed asymmetric [4+3] and [3+3] annulation reactions”,Angew. Chem. Int. Ed.2019,58, 15021.
36.Chong-Hui Shi, Ben-Xian Xiao, Wei Du, Ying-Chun Chen,* “Phosphine-catalyzed formal [6 + 2] cycloadditions ofa¢-methylene 2-cyclopentenones”,Chin. J. Org. Chem.2019,39, 2218.
37.Lin Chen, Ben-Xian Xiao, Wei Du, and Ying-Chun Chen,* “Quaternary phosphonium salts as active Brønsted acid catalysts for Friedel-Crafts reactions”,Org. Lett.2019,21, 5733.
38.Guang-Yao Ran,Xing-Xing Yang,Jing-Fei Yue, Wei Du,* and Ying-Chun Chen,* “Asymmetric allylic alkylations with deconjugated carbonyl compounds: Direct vinylogous umpolung strategy”,Angew. Chem. Int. Ed.2019,58, 9210.
39.Chang-Jiang Xu, Hong-Wei Li, Xiao-Long He, Wei Du,and Ying-Chun Chen,* “Asymmetric direct remote Michael addition reactions of allyl furfurals via dearomative trienamine and tetraenamine catalysis”，Asian J. Org. Chem.2019,8, 1037.
40.Bo Jiang, Ben-Xian Xiao, Qin Ouyang, Hua-Ping Liang,* Wei Du, and Ying-Chun Chen,* “Sequential assembly of Morita-Baylis-Hillman carbonates and activatedortho-vinylbenzaldehydes to construct chiralmethanobenzo[7]annulenoneframeworks”,Org. Lett.2019,21, 3310.
41.Xiao-Long He, Hui-Ru Zhao,Xue Song,Bo Jiang,Wei Du,*and Ying-Chun Chen,* “Asymmetric Barton-Zard reaction to access 3-pyrrole-containing axially chiral skeletons”,ACSCatal.2019,9,4374.
42.Rong Zeng, Changyu Shan, Ming Liu, Kun Jiang,* Ying Ye, Tian-Yu Liu, Ying-Chun Chen,* “[4 + 1 + 1] Annulations ofa-bromo carbonyls and 1-azadienes towards fused benzoazaheterocycles”,Org. Lett.2019,21, 2312.
43.Ben-Xian Xiao, Bo Jiang, Xue Song, Wei Du,and Ying-Chun Chen,* “Phosphine-catalysed asymmetric dearomative formal [4 + 2] cycloadditions of 3-benzofuranyl vinyl ketones”,Chem. Commun.2019,55, 3097.
44.Peng Chen,Zhi-Chao Chen, Yue Li,Qin Ouyang, Wei Du,* and Ying-Chun Chen,* “Auto-tandem cooperative catalysis using phosphine/palladium: Reaction of Morita-Baylis-Hillman carbonates and allylic alcohols”,Angew. Chem. Int. Ed.2019,58, 4036.
45.Qian-Qian Yang, Xiang Yin, Xiao-Long He, Wei Du,* and Ying-Chun Chen,* “Asymmetric formal [5 + 3] cycloadditions with unmodified Morita-Baylis-Hillman alcohols via double activation catalysis”,ACS Catal.2019,9, 1258.
46.Jing Gu, Ben-Xian Xiao, Qin Ouyang,* Wei Du, and Ying-Chun Chen,* “Phosphine-catalyzed interrupted Morita-Baylis-Hillman reaction and switchable domino reactions ofa-substituted activated olefins with formaldehyde and mechanism elucidation”,Chin. J. Chem.2019,37, 155.
47.Ben-Xian Xiao, Xin-Yue Gao, Wei Du,* and Ying-Chun Chen,* “Asymmetric reactions involving Lewis Base catalyst-tethered dearomatizativeintermediates”,Chem. Eur. J.2019,25, 1607.
2018年
48.Ru-Jie Yan, Ben-Xian Xiao, Qin Ouyang, Hua-Ping Liang,* Wei Du, and Ying-Chun Chen,* “Asymmetric dearomative formal [4 + 2] cycloadditions of N,4-dialkylpyridinium salts and enones to construct azaspiro[5.5]undecane frameworks”,Org. Lett.2018,20, 8000.
49.Zhi-Chao Chen, Peng Chen, Zhi Chen,Qin Ouyang, Hua-Ping Liang,* Wei Du, and Ying-Chun Chen,* “Organocatalytic enantioselective 1,3-difunctionalizations of Morita-Baylis-Hillman carbonates”,Org. Lett.2018,20, 6279.
50.Jing-Fei Yue, Guang-Yao Ran, Xing-Xing Yang, Wei Du,* and Ying-Chun Chen,* “Asymmetric Diels-Alder cycloadditions of benzofulvene-based 2,4-dienals via trienamine activation”,Org. Chem. Front.2018,5, 2676.
51.Wei Xiao, Zhi Zhou, Qian-Qian Yang, Wei Du,* and Ying-Chun Chen,* “Organocatalyticasymmetric four-component [5+1+1+1] cycloadditions via a quintuple cascade process”,Adv. Synth. Catal.2018,360, 3526.
52.Yuanchun Zhou, Zhi Zhou, Wei Du,* Yingchun Chen,* “Asymmetric inverse-electron-demand Diels-Alder reaction of 2-pyrone and 2,5-dienones via HOMO-activation”,Acta Chim. Sinica2018,76, 382.
53.Chuan-Qi Duan, Xiao-Long He, Wei Du,* and Ying-Chun Chen,* “Asymmetric [4 + 2] cycloadditions with 3-furfural derivatives anda-cyano-a,b-unsaturated ketones”,Org. Chem. Front.2018,5, 2057.
54.Xiao-Long He, Hui-Ru Zhao, Chuan-Qi Duan, Xu Han,Wei Du, and Ying-Chun Chen,* “Asymmetric benzylic allylic alkylation reaction of 3-furfural derivatives via dearomatizative dienamine activation”,Chem. Eur. J.2018,24, 6277.
55.Jing Gu, Ben-Xian Xiao, Yu-Rong Chen, Qing-Zhu Li,Qin Ouyang,*Wei Du,and Ying-Chun Chen,* “Interrupted Morita-Baylis-Hillman-type reaction ofa-substituted activated olefins”,Org. Lett.2018,20, 2088.
56.Xiao-Long He, Hui-Ru Zhao, Chuan-Qi Duan, Wei Du and Ying-Chun Chen,* “Remote asymmetric oxa-Diels-Alder reaction of 5-allylic furfurals via dearomatizative tetraenamine catalysis”,Org. Lett.2018, 20,804.
57.Qian-Qian Yang, Wei Xiao, Wei Du, Qin Ouyang,and Ying-Chun Chen,* “Asymmetric [4 + 2] annulations to construct norcamphor scaffolds with 2-cyclopentenone via double amine-thiol catalysis”,Chem. Commun.2018,54, 1129.
58.Wei Xiao, Qian-Qian Yang,Zhi Chen,Qin Ouyang,*Wei Du,and Ying-Chun Chen,* “Regio- and diastereodivergent [4 + 2] cycloadditions with cyclic 2,4-dienones”,Org. Lett.2018,20, 236.
2017年
59.Qing He, Wei Du, and Ying-Chun Chen,* “Asymmetric [3+2] annulations to construct 1,2-bispirooxindoles incorporating a dihydropyrrolidine motif”,Adv. Synth. Catal.2017,359, 3782.
60.Minglin Shi, Gu Zhan, Wei Du,* Yingchun Chen,* “Direct asymmetric aza-vinylogous Mannich reaction of nitrones from isatins and ketimines”,Acta Chim. Sinica2017,75, 998.
61.Ben-Xian Xiao, Ru-Jie Yan, Xin-Yue Gao, Wei Du, and Ying-Chun Chen,* “Asymmetric benzylic functionalizations of 3-vinyl benzofurans via cascade formal trienamine-vinylogous iminium ion activation”,Org. Lett.2017,19, 4652.
62.Zhou-Xiang Wang,Zhi Zhou,Wei Xiao, Qin Ouyang, Wei Du, and Ying-Chun Chen,* “Double activation catalysis fora¢-alkylidene cyclic enones with chiral amines and thiols”,Chem. Eur. J.2017,23, 10678.
63.Chao Li, Kun Jiang, Tian-Yu Liu,* and Ying-Chun Chen,* “Asymmetric [4+1] cycloadditions ofN-thioacyl Imines and sulfur ylides”,Adv. Synth. Catal.2017,359, 2530.
64.Xiao-Ru Zhang,Su-Lan Zhou, Yi Yuan, Wei Du, and Ying-Chun Chen,* “Chemo- and regioselective asymmetric Friedel-Crafts reaction of furans and thiophenes witha,b-unsaturated aldehydes through dual activation”,Synlett2017,28, 1771.
65.Gu Zhan,Ming-Lin Shi, Wei-Jia Lin, Qin Ouyang, Wei Du,* and Ying-Chun Chen,* “Direct asymmetric aza-vinylogous-type Michael additions of nitrones from isatins to nitroalkenes”,Chem. Eur. J.2017,23, 6286.
66.Guang-Yao Ran, Ming Gong, Jing-Fei Yue, Xing-Xing Yang, Su-Lan Zhou, Wei Du,and Ying-Chun Chen,* “Asymmetric cascade assembly of 1,2-diaza-1,3-dienes and α,β-unsaturated aldehydes via dienamine activation”,Org. Lett.2017,19, 1874.
67.Gu Zhan, Wei Du, Ying-Chun Chen,* “Switchable divergent asymmetric synthesis via organocatalysis”,Chem. Soc. Rev.2017,46, 1675.
68.Ben-Xian Xiao, Wei Du, and Ying-Chun Chen,* “Asymmetric dearomatizative Diels-Alder reaction for the construction of hydrodibenzo[b,d]furan frameworks with tetrasubstituted stereogenic centers”,Adv. Synth. Catal.2017,359, 1018.
69.Wei-Jia Lin,Gu Zhan,Ming-Lin Shi,Wei Du,* and Ying-Chun Chen,* “[3+3] formal cycloadditions of nitrones from isatins and azaoxyallyl cations for construction of spirooxindoles”,Chin. J. Chem.2017,35, 857.
70.Zhi Zhou, Zhou-Xiang Wang, Qin Ouyang, Wei Xiao, Wei Du, and Ying-Chun Chen,* “Cross-conjugated trienamine catalysis witha¢-alkylidene 2-cyclohexenones: application inb,g-regioselective aza-Diels-Alder reaction”,Chem. Eur. J.2017,23, 2945.
71.Zhi Zhou, Zhou-Xiang Wang, Yuan-Chun Zhou, Wei Xiao, Qin Ouyang,* Wei Du, Ying-Chun Chen,* “Switchable regioselectivity in amine-catalysed asymmetric cycloadditions”,Nat. Chem.2017,9, 590.
72.Kai-Kai Wang, Wei Du, Jin Zhu, Ying-Chun Chen,*“Construction of polycyclic spirooxindoles through [3+2] annulations of Morita−Baylis−Hillman carbonates and 3-nitro-7-azaindoles”,Chin. Chem. Lett.2017,28, 512.
2016年
73.Ming-Lin Shi,Gu Zhan, Su-Lan Zhou, Wei Du, and Ying-Chun Chen,* “Asymmetric inverse-electron-demand oxa-Diels-Alder reaction of allylic ketones through dienamine catalysis”,Org. Lett.2016,18, 6480.
74.Yu-Rong Chen,Gu Zhan,Wei Du,*and Ying-Chun Chen,* “Regioselective asymmetric formal (3+2) cycloadditions of nitrone ylides from isatins and enals”,Adv. Synth. Catal.2016,358,3759.
75.Guang-Jun Yang, Wei Du, and Ying-Chun Chen,* “Construction of furan derivatives with a trifluoromethyl stereogenic center: Enantioselective Friedel–Crafts alkylations via formal trienamine catalysis”,J. Org. Chem.2016,81, 10056.
76.Kai-Kai Wang,Pan Wang, Qin Ouyang,* Wei Du, and Ying-Chun Chen,* “Substrate-controlled switchable asymmetric annulations to access polyheterocyclic skeletons”,Chem. Commun.2016,52, 11104.
77.Xin Yuan, Shan-Jun Zhang,Wei Du, and Ying-Chun Chen,* “Asymmetric Diels–Alder cycloadditions of trifluoromethylated dienophiles via trienamine catalysis”,Chem. Eur. J.2016,22, 11048.
78.Chao Li,Kun Jiang,Qin Ouyang, Tian-Yu Liu,*and Ying-Chun Chen,* “[3 + 1]- and [3 + 2]-Cycloadditions of azaoxyallyl cations and sulfur ylides”,Org. Lett.2016,18, 2738.
79.Guang-Yao Ran,Pan Wang, Wei Du,and Ying-Chun Chen,* “α-Regioselective [3 + 2] annulations with Morita-Baylis-Hillman carbonates of isatins and 2-nitro-1,3-enynes”,Org. Chem. Front.2016,3, 861.
80.Qing He, Gu Zhan, Wei Du and Ying-Chun Chen,* “Application of 7-azaisatins in enantioselective Morita–Baylis–Hillman reaction”,Beilstein J. Org. Chem.2016,12, 309.
81.Kai-Kai Wang,Tian Jin,Xin Huang, Qin Ouyang,* Wei Du,and Ying-Chun Chen,* “a-Regioselective asymmetric [3 + 2] annulations ofMoritaBaylisHillman carbonates with cyclic 1-azadienes and mechanism elucidation”,Org. Lett.2016,18, 872.
82.Jing Gu, Ben-Xian Xiao, Yu-Rong Chen, Wei Du, and Ying-Chun Chen,* “Asymmetric Diels-Alder and cascade reaction of quinone imine ketals and 2,4-dienals: Construction of chiral benzo[de]quinolone derivatives”,Adv. Synth. Catal.2016,358, 296.
83.Gu Zhan, Ming-Lin Shi, Qing He, Wei-Jia Lin, Qin Ouyang,* Wei Du, and Ying-Chun Chen,* “Catalyst-controlled switch in chemo- and diastereoselectivities: Annulations of Morita-Baylis-Hillman carbonates from isatins”,Angew. Chem. Int. Ed.2016,55,2147.
84.Wei Xiao,Xiang Yin, Zhi Zhou, Wei Du,and Ying-Chun Chen,* “Asymmetrica,g-regioselective [3 + 3] formal cycloadditions ofa,b-unsaturated aldehydes via cascade dienamine-dienamine catalysis”,Org. Lett.2016,18, 116.
2015年
85.Jing Gu, Wei Du, and Ying-Chun Chen,* “Combined asymmetric aminocatalysis and carbene catalysis”,Synthesis2015,47, 3451.
86.Gu Zhan, Ming-Lin Shi,Qing He,Wei Du, and Ying-Chun Chen,* “[4 + 3] Cycloadditions with bromo-substitutedMorita−Baylis−Hillmanadducts of isatinsandN-(ortho-chloromethyl)aryl amides”,Org. Lett.2015,17, 4750.
87.Jing Peng, Guang-Yao Ran,Wei Du, and Ying-Chun Chen,* “Divergent cyclization reactions of Morita-Baylis-Hillman carbonates of 2-cyclohexenone and isatylidene malononitriles”,Org. Lett.2015,17, 4490.
88.Chao Li, Kun Jiang,* and Ying-Chun Chen,* “Diastereodivergent and enantioselective [4+2] annulations of γ-butenolides with cyclic 1-azadienes”,Molecules2015,20, 13642.
89.Peng-Fei Zheng, Qin Ouyang, Sheng-Li Niu, Li Shuai, Yi Yuan, Kun Jiang, Tian-Yu Liu,* and Ying-Chun Chen,* “Enantioselective [4+1] annulation reactions ofa-substituted ammonium ylides to construct spirocyclic oxindoles”,J. Am. Chem. Soc.2015,137, 9390.
90.Jing Peng, Guang-Yao Ran, Wei Du, and Ying-Chun Chen,* “Tertiary amine-catalyzed asymmetric [3+2] annulations of Morita-Baylis-Hillman carbonates of isatins with nitroolefins to construct spirooxindoles”,Synthesis2015,47, 2538.
91.Xiao-Long He, You-Cai Xiao,Wei Du, and Ying-Chun Chen,* “Enantioselective formal [3 + 3] cycloadditions of ketones and cyclic 1-azadienes via cascade enamine-enamine catalysis”,Chem. Eur. J.2015,21, 3443.
92.Kun, Jiang,and Ying-Chun Chen,* “The development of asymmetric trienamine catalysis”,Prog. Chem.2015,27, 137.
2014年
93.Gu Zhan, Qing He,Xin Yuan, and Ying-Chun Chen,* “Asymmetric direct vinylogous Michael additions of allyl alkyl ketones to maleimides through dienamine catalysis”,Org. Lett.2014,16, 6000.
94.Gu Zhan, Qing-Qing Zhou, Wei Du, and Ying-Chun Chen,* “EnantioselectiveN-allylic alkylation of propargyl sulfonamides with Morita-Baylis-Hillman carbonates and sequential electrophilic cyclization”,Synthesis2014,46, 3383.
95.Xin Feng, Zhi Zhou, Xiang Yin, Rui Li,* and Ying-Chun Chen,* “Enantioselective direct bisvinylogous 1,6-additions ofb-allyl 2-cyclohexenone toa,a-dicyanodienes through trienamine catalysis”,Eur. J. Org. Chem.2014, 5906.
96.Qing-Zhu Li,Jing Gu,and Ying-Chun Chen,* “Organocatalytic asymmetric [4+2] formal cycloadditions ofcyclohexenylidenemalononitriles and enals to construct chiral bicyclo[2.2.2]octanes”,RSC Adv.2014,4, 37522.
97.Jing Gu,Chao Ma, Qing-Zhu Li, Wei Du, and Ying-Chun Chen,* “β,γ-Regioselective inverse-electron-demand aza-Diels-Alder reactions withα,β-unsaturated aldehydes via dienamine catalysis”,Org. Lett.2014,16, 3986.
98.Rong Zhou, Wei Xiao, Xiang Yin, and YingChun Chen,* “Diastereo- and enantioselective [4+2] cycloadditions of cyclic enones with cyclic 1-azadienes”,Acta Chim. Sinica2014,72, 862.
99.You-Cai Xiao, Cai-Zhen Yue, Peng-Qiao Chen, and Ying-Chun Chen,* “Asymmetric dearomatic Diels-Alder reactions of diverse heteroarenes viap-system activation”,Org. Lett.2014,16, 3208.
100.Xiang Yin, Yi Zheng, Xin Feng, Kun Jiang, Xue-Zhen Wei, Ning Gao,* and Ying-Chun Chen,* “Asymmetric [5 + 3] formal cycloadditions with cyclic enones through cascade dienamine-dienamine catalysis”,Angew. Chem. Int. Ed.2014,53, 6245.
101.Jun-Long Li,Cai-Zhen Yue, Peng-Qiao Chen, You-Cai Xiao,and Ying-Chun Chen,* “Remote enantioselective Friedel-Crafts alkylations of furans via HOMO-activation”,Angew. Chem. Int. Ed.2014,53, 5449.
102.Zhi Zhou, Xin Feng, Xiang Yin, and Ying-Chun Chen,* “Direct remote asymmetric bisvinylogous 1,4-additions of cyclic 2,5-dienones to nitroalkenes”,Org. Lett.2014,16, 2370.
103.Peng-Qiao Chen, You-Cai Xiao, Cai-Zhen Yue, and Ying-Chun Chen,* “Trienamine catalysis with linear deconjugated 3,5-dienones”,Org. Chem. Front.2014,1, 490.
104.Qing-Qing Zhou, You-Cai Xiao, Xin Yuan, and Ying-Chun Chen,* “Asymmetric Diels-Alder reactions of 2,4,6-trienals via tetraenamine catalysis”,Asian J. Org. Chem.2014,3, 545.
105.Kun Jiang,* Ying-Chun Chen,* “Organocatalyticreactions involving nitrogen-ylides”,Tetrahedron Lett.2014,55, 2049.
2013年
106.Xin Feng, Zhi Zhou, Chao Ma, Xiang Yin, Rui Li,* Lin Dong, and Ying-Chun Chen,* “Trienamines derived from interrupted cyclic 2,5-dienones: remote δ,ɛ-C=C bond activation for asymmetric inverse-electron-demandaza-Diels-Alder reaction”,Angew. Chem. Int. Ed.2013,52, 14173.
107.Chao Ma, Jing Gu, Bin Teng, Qing-Qing Zhou, Rui Li,* and Ying-Chun Chen,* “1-Azadienes as regio- and chemoselective dienophiles in aminocatalytic asymmetric Diels–Alder reaction”,Org. Lett.2013,15, 6206.
108.Qing-Qing Zhou, Xin Yuan, You-Cai Xiao, Lin Dong, and Ying-Chun Chen*“Aminocatalytic asymmetric Diels-Alder reaction of phosphorus dienophiles and 2,4-dienals”,Tetrahedron2013,69, 10369.
109.Jing-Xin Liu, Qing-Qing Zhou,Jin-Gen Deng, and Ying-Chun Chen,*“An asymmetric normal-electron-demand aza-Diels– Alder reaction via trienamine catalysis”,Org. Biomol. Chem.2013,11, 8175.
110.Jing Peng, Xin Huang, Peng-Fei Zheng, and Ying-Chun Chen,*“Rauhut-Currier-type reaction with Morita-Baylis-Hillman carbonates of 2-cyclohexenone and alkylidenemalononitriles to access chromene derivatives”,Org. Lett.2013,15, 5534.
111.Quan-Gang Wang, Qing-Qing Zhou, Jin-Gen Deng,and Ying-Chun Chen,*“An asymmetric allylic alkylation-Smiles rearrangement-sulfinate addition sequence to construct chiral cyclic sulfones”,Org. Lett.2013,15, 4786.
112.Zhi-Jun Jia,Kun Jiang,Qing-Qing Zhou, Lin Dong, Ying-Chun Chen*, “Amine/N-heterocyclic carbene cascade catalysis for asymmetric synthesis of fused indane derivatives with multiple chiral centres,Chem. Commun.2013,49, 5892.
113.Yuan Yao, Jun-Long Li, Qing-Qing Zhou, Lin Dong, Ying-Chun Chen,* “Enantioselective aza-Morita-Baylis-Hillman reaction with ketimines and acrolein catalyzed by organic assemblies”,Chem. Eur. J.2013,19, 9447.
114.Shan-Jun Zhang, Jun Zhang,Qing-Qing Zhou, Lin Dong, and Ying-Chun Chen,* “Aminocatalytic asymmetricexo-Diels-Alder reaction with methiodide salts of Mannich bases and 2,4-dienals to construct chiral spirocycles”,Org. Lett.2013,15, 968.
115.Chao Ma, Zhi-Jun Jia, Jing-Xin Liu, Qing-Qing Zhou, Lin Dong, and Ying-Chun Chen,* “A concise assembly of electron-deficient 2,4-dienes and 2,4-dienals: regio- and stereoselectiveexo-Diels-Alder and redox reaction via sequential amine and carbene catalysis”,Angew. Chem. Int. Ed.2013,52, 948.
2012年
116.You-Cai Xiao, Qing-Qing Zhou, Lin Dong, Tian-Yu Liu, and Ying-Chun Chen,* “Asymmetric Diels-Alder reaction of 2-methyl-3-indolylmethanols via in situ generation ofortho-quinodimethanes”,Org. Lett.2012,14, 5940.
117.Xin Feng, Zhi Zhou,Rong Zhou,Qing-Qing Zhou,Lin Dong, and Ying-Chun Chen,* “Stereodivergence in amine-catalyzed regioselective [4+2] cycloadditions of beta-substituted cyclic enones and polyconjugated malononitriles”,J. Am. Chem. Soc.2012,134, 19942.
118.Xiang Yin, Qingqing Zhou, Lin Dong, Yingchun Chen,* “Asymmetric sequential aza-Diels-Alder andO-Michael addition: Efficient construction of chiral hydropyrano[2,3-b]pyridines”,Chin. J. Chem.2012,30, 2669.
119.Xunhao Sun, Jing Peng, Shuyang Zhang, Qingqing Zhou, Lin Dong, Yingchun Chen,*“Asymmetric allylic alkylation of cyclicN-sulfonylimines with Morita–Baylis–Hillman carbonates of isatins”,Acta Chimi. Sinica2012,70, 1682.
120.Hang Zhang, Shan-Jun Zhang, Qing-Qing Zhou, Lin Dong, and Ying-Chun Chen*, “Organocatalytic asymmetric allylic amination of Morita-Baylis-Hillman carbonates of isatins”,Beilstein J. Org. Chem.2012,8, 1241.
121.Jun-Long, Li, Tian-Yu, Liu, andYing-Chun Chen,* “Aminocatalytic asymmetric Diels-Alder reactions via HOMO activation”,Acc. Chem. Res.2012,45, 1491.
122.Tian-Yu Liu, Min Xie, andYing-Chun Chen,* “Organocatalytic asymmetric transformations of modified Morita-Baylis-Hillman adducts”,Chem. Soc. Rev.2012,41, 4101.
123.Qing-Zhu Li, Lei Ma, Lin Dong, andYing-Chun Chen,* “Asymmetric aza-Diels-Alder and cation-olefin cyclization sequence: A concise way to fused chiralcyclopenta[b]piperidines”,ChemCatChem2012,4, 1139.
124.Jun-Long Li,Si-Li Zhou, Peng-Qiao Chen, Lin Dong,Tian-Yu Liu,andYing-Chun Chen,* “Asymmetric Diels-Alder reaction ofb,b-disubstitutedenals and chromone-fused dienes: construction of collections with high molecular complexity and skeletal diversity”,Chem. Sci.2012,3, 1879.
125.Xiao-Feng Xiong, Quan Zhou, Jing Gu, Lin Dong, Tian-Yu Liu,andYing-Chun Chen,* “Trienamine catalysis with 2,4-dienones: development and application in asymmetric Diels-Alder reaction”,Angew. Chem. Int. Ed.2012,51, 4401.
126.Xin Huang,Jin Peng,Lin Dong, andYing-Chun Chen,* “Asymmetric assembly of 2-oxindole anda-angelica lactone units to construct vicinal quaternary chiral centers”,Chem. Commun.2012,48, 2439.
2011年
127.Bo Han, Jun-Long Li, You-Cai Xiao, Si-Li Zhou, andYing-Chun Chen,* “Thiourea-catalyzed asymmetric Mannich-type reactions”,Curr. Org. Chem.2011,15, 4128.
128.Hai-Lei Cui, Xun-Hao Sun, Lin Jiang, Lin Dong, andYing-Chun Chen,* “Lewis base-assisted Brønsted base catalysis: direct asymmetric allylic alkylation of indenes”,Eur. J. Org. Chem.2011, 7366.
129.Si-Li Zhou, Jun-Long Li, Lin Dong, andYing-Chun Chen,* “Organocatalytic sequential hetero-Diels-Alder and Friedel-Crafts reaction: constructions of fused heterocycles with scaffold diversity”,Org. Lett.2011,13, 5874.
130.You-Cai Xiao, Chao Wang, Yuan Yao,Jian Sun,* and Ying-Chun Chen,* “Direct asymmetric hydrosilylation of indoles: Combined Lewis base and Brønsted acid activation”,Angew. Chem. Int. Ed.2011,50, 10661.
131.Jing Peng, Xin Huang, Lin Jiang, Hai-Lei Cui, andYing-Chun Chen,* “Tertiary amine-catalyzed chemoselective and asymmetric [3 + 2] annulation of Morita-Baylis-Hillman carbonates of isatins with propargyl sulfones”,Org. Lett.2011,13, 4584.
132.Zhi-Jun Jia, Quan Zhou, Qing-Qing Zhou,Peng-Qiao Chen, and Ying-Chun Chen,* “Exo-selective asymmetric Diels-Alder reaction of 2,4-dienals and nitroalkenes via trienamine catalysis”,Angew. Chem., Int. Ed.2011,50,8638.
133.Lin Jiang, Qian Lei, Xin Huang,Hai-Lei Cui, Xue Zhou,and Ying-Chun Chen,* “Lewis base assisted Brønsted base catalysis: direct regioselective asymmetric vinylogous alkylation of allylic sulfones”,Chem. Eur. J.2011,17, 9489.
134.Zhi-Jun Jia, Hao Jiang, Jun-Long Li,Björn Gschwend,Qing-Zhu Li,Xiang Yin, Julie Grouleff,Ying-Chun Chen,*and Karl Anker Jørgensen,* “Trienamines in asymmetric organocatalysis: Diels-Alder and cascade reactions”,J. Am. Chem. Soc.2011,133, 5053.
135.Ji-Rong Huang, Hai-Lei Cui, Jie Lei, Xun-Hao Sun, and Ying-Chun Chen,* “Organocatalytic chemoselective asymmetricN-allylic alkylation of enamides”,Chem. Commun.2011,47, 4784.
136.Lin Jiang, and Ying-Chun Chen,* a review, “Recent advance in asymmetric catalysis with cinchona alkaloid-based primary amines”,Catal. Sci. Technol.2011,1, 354.
137.Jing Peng, Hailei Cui, and Yingchun Chen,* “Organocatalytic asymmetric allylic alkylation of sulfonylimidates with Morita-Baylis-Hillman carbonates”,Science China: Chemistry2011,54, 81.
138.Xiao-Feng Xiong,Hang Zhang,Jing Peng, and Ying-Chun Chen,* “Direct asymmetric Michael addition of cyclicN-sulfonylimines toa,b-unsaturated aldehydes”,Chem. Eur. J.2011,17, 2358.
2010年
139.Bo Han, You-Cai Xiao, Yuan Yao, Ying-Chun Chen,* “Lewis acid-catalyzed intramolecular direct ene reaction of indoles”,Angew. Chem., Int. Ed.2010,49, 10189.
140.Jing Peng, Xin Huang, Hai-Lei Cui, Ying-Chun Chen,* “Organocatalytic and electrophilic approach to oxindoles with C3-quaternary stereocenters”,Org. Lett.2010,12, 4260.
141.Jun-Long Li, Tai-Ran Kang, Si-Li Zhou,Rui Li, Li Wu,Ying-Chun Chen,* “Organocatalytic asymmetric inverse-electron-demand Diels-Alder reaction of electron-deficient dienes and crotonaldehyde”,Angew. Chem., Int. Ed.2010,49,6418.
142.Zhao-Quan He, Quan Zhou, Li Wu, and Ying-Chun Chen,* “Asymmetric organocatalytic tandem reaction to chiralpyrimidinone derivatives using urea as dinitrogen source”,Adv. Synth. Catal.2010,352, 1904.
143.Xin Feng, Hai-Lei Cui, Shi Xu, Li Wu, and Ying-Chun Chen,* “Organocatalytic direct vinylogous Michael addition ofa,b-unsaturatedg-butyrolactam toa,b-unsaturated aldehydes and an illustration to scaffold diversity synthesis”,Chem. Eur. J.2010,16, 10309.
144.Hailei Cui, Kun Jiang, Yankai Liu, Wei Du,Yingchun Chen,* “Enantioselective direct aldol-type reaction of 4-hydroxycoumarin with ethyl trifluoropyruvate catalyzed by modified cinchona alkaloids”,Chin. Sci. Bull.2010,55, 1732.
145.Kun Jiang, Zhi-Jun Jia, Xiang Yin, Li Wu, and Ying-Chun Chen,* “Asymmetric quadruple aminocatalytic domino reactions to fused carbocycles incorporating a spirooxindole motif”,Org. Lett.2010,12, 2766.
146.Jie Lei,Hai-Lei Cui,Rui Li,* Li Wu, Zheng-Yu Ding and Ying-Chun Chen,* “Tributyltin hydride-mediated radical cyclisation reactions: efficient construction of multiply substituted cyclopentanes”,Org. Biomol. Chem.2010, 8, 2840.
147.Jun-Long Li, Si-Li Zhou, Bo Han, Li Wu, and Ying-Chun Chen,* “Aminocatalytic asymmetric inverse-electron-demand aza-Diels–Alder reaction ofN-Ts-1-aza-1,3-butadienes based on coumarin cores”,Chem. Commun.2010,46, 2665.
148.Hai-Lei Cui, Ji-Rong Huang, Jie Lei, Zhao-Feng Wang, Shi Chen, Li Wu, and Ying-Chun Chen,* “Direct asymmetric allylic alkylation of butenolides with Morita-Baylis-Hillman carbonates”,Org. Lett.2010,12,720.
149.Kun Jiang,Zhi-Jun Jia,Shi Chen,Li Wu,and Ying-Chun Chen,* “Organocatalytic tandem reaction to construct six-membered spirocyclic oxindoles with multiple chiral centres via a formal [2+2+2] annulation”,Chem. Eur. J.2010,16, 2852.
150.Zhao-Quan He,Bo Han,Rui Li,*Li Wu,and Ying-Chun Chen,*“Enantioselective construction of lactone[2,3-b]piperidine skeletons via organocatalytic tandem reactions”,Org. Biomol. Chem.2010,8, 755.
2009年
151.Xiao-Feng Xiong,Zhi-Jun Jia, Wei Du, Kun Jiang, Tian-Yu Liu, and Ying-Chun Chen,*“Merging chiral organocatalysts: enantio- and diastereoselective direct vinylogous Mannich reaction of alkylimines”,Chem. Commun.2009, 6994.
152.Bo Han,You-Cai Xiao, Zhao-Quan He, and Ying-Chun Chen,*“Asymmetric Michael addition ofg,g-disubstituteda,b-unsaturated aldehydes to nitroolefins via dienamine catalysis”,Org. Lett.2009,11, 4660.
153.Shan-Jun Zhang, Hai-Lei Cui, Kun Jiang, Rui Li,* Zhen-Yu Ding, and Ying-Chun Chen,*“Enantioselective allylic amination of Morita-Baylis-Hillman carbonates catalyzed by modified cinchona alkaloids”,Eur. J. Org. Chem.2009, 5804.
154.ZeKai Hu, HaiLei Cui, Kun Jiang, YingChun Chen*, “EnantioselectiveO-allylic alkylation of Morita-Baylis-Hillman carbonates with oxime”,Sci. China Ser. B: Chem.2009,52, 1309.
155.Xin Feng, Yu-Qing Yuan, Hai-Lei Cui, Kun Jiang, and Ying-Chun Chen,*“Organocatalyticperoxy-asymmetric allylic alkylation”,Org. Biomol. Chem.2009,7, 3660.
156.Hai-Lei Cui,Xin Feng, Jing Peng, Jie Lei, Kun Jiang, andYing-Chun Chen,*“Chemoselective asymmetricN-allylic alkylation of indoles with Morita-Baylis-Hillman carbonates”,Angew. Chem., Int. Ed.2009,48, 5737.
157.Bo Han,Zhao-Quan He, Jun-Long Li, Rui Li,Kun Jiang, Tian-Yu Liu, and Ying-Chun Chen,* “Organocatalytic regio- and stereoselective inverse-electron-demand aza-Diels-Alder reaction ofa,b-unsaturated aldehydes andN-Tosyl-1-aza-1,3-butadienes”,Angew. Chem., Int. Ed.2009,48, 5474.
158.Yan-Kai Liu, Chao Ma, Kun Jiang, Tian-Yu Liu, and Ying-Chun Chen,* “Asymmetric tandem Michael addition-Wittig reaction to cyclohexenone annulation”,Org. Lett.2009,11, 2848.
159.Kun Jiang,Jing Peng, Hai-Lei Cui, and Ying-Chun Chen,* “Organocatalytic asymmetric allylic alkylation of oxindoles with Morita-Baylis-Hillman carbonates”,Chem. Commun.2009, 3955.
160.Hai-Lei Cui,Ying-Chun Chen,*a Feature Article, “alfa,alfa-Dicyanoalkenes: versatile vinylogous nucleophiles for organic synthesis”,Chem. Commun.2009, 4479.
161.Jun-Long Li, Bo Han, Kun Jiang, Wei Du, and Ying-Chun Chen,* “Organocatalytic enantioselective hetero-Diels-Alder reaction of aldehydes ando-benzoquinone diimide: Synthesis of optically active hydroquinoxalines”,Bioorg. Med. Chem. Lett.2009,19, 3952.
162.Hai-Lei Cui, Jing Peng, Xin Feng, Wei Du, Kun Jiang, and Ying-Chun Chen,* “Dual organocatalysis: Asymmetric allylic-allylic alkylation ofa,a-dicyanoalkenes and Morita-Baylis-Hillman carbonates”,Chem. Eur. J.2009,15, 1574.
2008年
163.Bo Han, Jun-Long Li, Chao Ma, Shan-Jun Zhang, and Ying-Chun Chen,* “Organocatalytic asymmetric inverse electron demand aza Diels-Alder reaction ofN-sulfonyl-1-aza-1,3-butadienes and aldehydes”,Angew. Chem., Int. Ed.2008,47, 9971.
164.Wei Du, Yan-Kai Liu, Lei Yue, and Ying-Chun Chen,* “Organocatalytic asymmetric 1,3-dipolar cycloaddition of nitrones to nitroolefins”,Synlett2008, 2997.
165.Yan-Kai, Liu, Hao Liu, Wei Du, Lei Yue, and Ying-Chun Chen,*“Reaction control in the organocatalytic asymmetric one pot, three-component reaction of aldehydes, diethyla-aminomalonate and nitroalkenes: toward diversity-oriented synthesis”,Chem. Eur. J.2008,14, 9873.
166.Bo Han, Qing-Ping Liu, Rui Li, Xu Tian, Xiao-Feng Xiong, Jin-Gen Deng, and Ying-Chun Chen,* “Discovery of bifunctional thiourea-secondary amine organocatalysts for thehighly stereoselective nitro-Mannich reaction ofa-substituted nitroacetates”,Chem. Eur. J.2008,14, 8094.
167.Xu Tian, Kun Jiang, Jing Peng, Wei Du, and Ying-Chun Chen,*“Organocatalytic stereoselective Mannich reaction of 3-oxindoles”,Org. Lett.2008,10, 3583.
168.Tai-Ran Kang, Jian-Wu Xie, Wei Du, Xin Feng, and Ying-Chun Chen,* “Stereoselective desymmetrisation of prochirala,a-dicyanoalkenes via domino Michael-Michael addition reactions”,Org. Biomol. Chem.2008, 6, 2673.
169.Ying-Chun Chen,* an account, “The development of asymmetric primary aminocatalysts based on cinchona alkaloids”,Synlett2008, 1919.
170.Lei Yue, Wei Du, Yan-Kai Liu, Y Ying-Chun Chen,* “Organocatalytic asymmetric direct Michael addition of aromatic ketones to alkylidenemalononitriles”,Tetrahedron Lett.2008,49, 3881.
171.Yan Zhang, Yan-Kai Liu, Tai-Ran Kang, Ze-Kai Hu, Ying-Chun Chen,*“Organocatalytic enantioselective Mannich-type reaction of phosphorus ylides: Synthesis of chiralN-Boc-b-amino-a-methylene carboxylic esters”,J. Am. Chem. Soc.2008,130, 2456.
2007年
172.Wei Chen,Wei Du, Yong-Zheng Duan, Yong Wu,Sheng-Yong Yang,Ying-Chun Chen,*“Enantioselective 1,3-dipolar cycloaddition of cyclic enones catalyzed by multifunctional primary amine: beneficial effects of hydrogen bonding”,Angew. Chem., Int. Ed.2007,46, 7667.
173.Tian-Yu Liu,Hai-Lei Cui, Yan Zhang, Kun Jiang, Zhao-Quan He, Bang-Jing Li, Li-Sheng Ding, Ying-Chun Chen,* “Organocatalytic and highly enantioselective directa-amination of aromatic ketones”,Org. Lett.2007,9, 3671.
174.Tian-Yu Liu,Hai-Lei Cui, Qian Chai, Jun Long, Bang-Jing Li, Yong Wu, Li-Sheng Ding, Ying-Chun Chen,*“Organocatalytic asymmetric Friedel-Crafts alkylation/cascade reactions of naphthols and nitroolefins”,Chem. Commun.2007, 2228.
175.Lin Jiang, Hong-Ting Zheng, Tian-Yu Liu, Lei Yue, Ying-Chun Chen,* “Asymmetric direct vinylogous carbon-carbon bond formation catalyzed by bifunctional organocatalysts”,Tetrahedron2007, 63, 5123.
176.Tian-Yu Liu,Hai-Lei Cui, Jun Long, Bang-Jing Li, Yong Wu, Li-Sheng Ding, Ying-Chun Chen,* “Organocatalytic and highly stereoselective direct vinylogous Mannich reaction”,J. Am. Chem. Soc.2007,129, 1878.
177.Wei Chen, Wei Du,Lei Yue, Rui Li,Yong Wu, Li-Sheng Ding and Ying-Chun Chen,* “Organocatalytic enantioselective indole alkylations ofa,b-unsaturated ketones”,Org. Biomol. Chem.2007, 5, 816.
178.Jian-Wu Xie, Lei Yue,Wei Chen,Wei Du, Jin Zhu, Jin-Gen Dengand Ying-Chun Chen,* “Highly enantioselective Michael addition of cyclic 1,3-dicarbonyl compounds toa,b-unsaturated ketones”,Org. Lett.2007, 9, 413.
179.Jian-Wu Xie, Wei Chen,Rui Li, Mi Zeng,Wei Du, Lei Yue,Ying-Chun Chen,* Yong Wu, Jin Zhu, and Jin-Gen Deng,* “Highly asymmetric Michael addition ofa,b-unsaturated ketones catalyzed by 9-amino-9-deoxyepiquinine”,Angew. Chem., Int. Ed.2007,46, 389.
180.Tian-Yu Liu, Rui Li,Qian Chai, Jun Long, Bang-Jing Li, Yong Wu,Li-Sheng Ding, Ying-Chun Chen,* “Enantioselective Michael addition ofa-substituted cyanoacetates to vinyl ketones catalyzed by bifunctional organocatalysts”,Chem.−Eur. J.2007,13, 319.
2006年
181.Wei Chen, Xiang-Hong Yuan, Rui Li, Wei Du,Yong Wu, Li-Sheng Ding, Ying-Chun Chen,* “Organocatalytic and stereoselective [3 + 2] cycloadditions of azomethine imines witha,b-unsaturated aldehydes”,Adv. Synth. Catal.2006,348, 1818.
182.Wei Chen, Rui Li, Yong Wu, Li-Sheng Ding, Ying-Chun Chen,* “Self-supported thiourea-palladium complexes: highly air-stable and recyclable catalysts for the Suzuki reaction in neat water”,Synthesis2006, 3058.
183.Lin Jiang, Tong-Fei Wu, Ying-Chun Chen,* Jin Zhu, Jin-Gen Deng,* “Asymmetric transfer hydrogenation catalysed by hydrophobic dendritic DACH-rhodium complex in water”,Org. Biomol. Chem.2006,4, 3319.
184.Tian-Yu Liu, Jun Long, Bang-Jing Li, Lin Jiang, Rui Li, Yong Wu, Li-Sheng Ding, Ying-Chun Chen,* “Enantioselective construction of quaternary carbon centre catalysed by bifunctional organocatalyst”,Org. Biomol. Chem.2006,4, 2097.
185.Qing-Ping Liu, Ying-Chun Chen,* Yong-Wu, Jin Zhu, Jin-Gen Deng,* “Self-supported heterogeneous star-shaped oxime-palladacycle catalysts for the Suzuki coupling reaction”,Synlett2006, 1503.
186.Yan-Kai Liu, Rui Li, Lei Yue, Ying-Chun Chen,* Yong Wu, Li-Sheng Ding, “Unexpected ring-opening reactions of aziridines with aldehydes catalyzed by nucleophilic carbenes under aerobic conditions”,Org. Lett.2006,8, 1521.
187.Jian-Wu Xie, Lei Yue, Dong Xue, Xiao-Li Ma, Ying-Chun Chen,* Yong Wu, Jin Zhu, Jin-Gen Deng,* “Organocatalytic and direct asymmetric vinylogous Michael addition ofa,a-dicyanoolefins toa,b-unsaturated aldehydes”,Chem. Commun.2006, 1563.
188.Wei Chen, Rui Li, Bo Han, Bang-Jing Li,Ying-Chun Chen,*Yong Wu, Li-Sheng Ding, Dan Yang，“Design and synthesis of bis-thiourea ligands and their application in Pd-catalyzed Heck and Suzuki reactions under aerobic condition”,Eur. J. Org.Chem.2006, 1177.
189.Zhi-Quan Yong, Xiao-Ping Xu, Ying-Chun Chen,* Xu Bao, Ling-Ling Weng,* Hu Zheng, “Synthesis and cytotoxic activity of novel water-soluble prodrugs of combretastatin A-4”,Chin. Chem. Lett.2006,17, 23.
2005年前
190.Dong Xue,Ying-Chun Chen,*Qi-Wei Wang, Ling-Feng Cun, Jin Zhu, Jin-Gen Deng,* “Asymmetric direct vinylogous Michael reaction of activated alkenes to nitroolefins catalyzed by modified cinchona alkaloids”,Org. Lett.2005,7, 5293.
191.Bang-Jing Li, Lin Jiang, Min Liu,Ying-Chun Chen,* Li-Sheng Ding, Yong Wu, “Asymmetric Michael addition of thiols toa,b-unsaturated carbonyl compounds catalyzed by bifunctional organocatalyst”,Synlett2005, 603.
192.Dong Xue,Ying-Chun Chen,Qi-Wei Wang, Xin Cui, Jin Zhu, Jin-Gen Deng,“Transfer hydrogenation of activated C=C bonds catalyzed by ruthenium amido complexes: reaction scope, limitation, andenantioselectivity”,J. Org. Chem.2005,70, 3584.
193.Ying-Chun Chen,* Tong-Fei Wu, Lin Jiang, Xin Cui, Jin-Gen Deng,* Jin Zhu, Yao-Zhong Jiang,“Synthesis of dendritic ligands and application in asymmetric transfer hydrogenation”,J. Org. Chem.2005,70, 1006.
194.Chun-Yu Ho, Ying-Chun Chen,Man-King Wong, Dan Yang,“Fluorinated chiral secondary amines as catalysts for epoxidation of olefins with oxone”,J. Org. Chem.2005,70, 898.
195.Dan Yang,* Ying-Chun Chen, Nian-Yong Zhu, “Sterically bulky thioureas as air- and moisture-stable ligands for Pd-catalyzed Heck reactions of aryl halides”,Org. Lett.2004,6, 1577.
196.Ying-Chun Chen, Dong Xue, Jin-Gen Deng, Xin Cui, Jin Zhu, Yao-Zhong Jiang, “Efficient asymmetric transfer hydrogenation of activated olefins catalyzed by ruthenium amido complexes”,Tetrahedron Lett.2004,45, 1555.
197.Pei Nian Liu, Ying-Chun Chen, Xue Qiang Li, Yong Qiang Tu, Jin Gen Deng, “Dendritic catalysts for asymmetric transfer hydrogenation based on (1S,2R)-norephedrine derived ligands”,Tetrahedron: Asymmetry2003,14, 2481.
198.Ying-Chun Chen, Tong-Fei Wu, Jin-Gen Deng, Hui Liu, Xin Cui, Jin Zhu, Yao-Zhong Jiang, Michael C. K. Choiand Albert S. C. Chan, “Multipledendritic catalysts for asymmetric transfer hydrogenation”,J. Org. Chem.2002, 67,5301.
199.Ying-Chun Chen,Tong-Fei Wu, Jin-Gen Deng, Hui Liu, Yao-Zhong Jiang, Michael C. K. Choiand Albert S. C. Chan, “Dendritic catalysts for asymmetric transfer hydrogenation”,Chem. Commun.2001, 1488.
200.Peilian Liu,Yingchun Chen, Jingen Deng, Yongqiang Tu, “Efficient method for the preparation of benzylic bromides”,Synthesis2001, 2078.
