周洲 副教授 (博士生导师) 
单位：四川大学华西药学院药剂系
通讯地址：成都市人民南路三段17号四川大学华西药学院
E-mail: zhou_zhou610@163.com
简历
2005-2009 中山大学药学院，获理学学士学位
2009-2015 四川大学华西药学院，获药剂学博士学位
2015- 四川大学华西药学院药剂系任讲师、副教授
2018-2019 美国犹他大学药学院访问学者
研究方向
靶向给药系统的构建及其作用机制研究
主要研究课题
1. 国家自然科学基金委员会，面上项目，82373819，2024至2027，主持。
2. 国家自然科学基金委员会，青年基金项目，81603042，2017至2019，主持。
3. 四川省科技厅，重点研发项目，2018SZ0032，2018至2019，主持。
4. 四川大学青年教师启动基金，2016SCU11008，2016至2017，主持。
代表性论著
1. Jing Tao, Yuan Yao, Minyi Huang, Jiahui Wu, Jiayan Lyu, Qiuyi Li, Lian Li, Yuan Huang, Zhou Zhou*. A nano-platform combats the “attack” and “defense” of cytoskeleton to block cascading tumor metastasis. Journal of Controlled Release, 2024, 367: 572-586.
2. Jiayan Lyu, Huizhi Liu, Liqiang Chen, Chendong Liu, Jing Tao, Yuan Yao, Lian Li, Yuan Huang, Zhou Zhou*. In situ hydrogel enhances non-efferocytic phagocytosis for post-surgical tumor treatment. Journal of Controlled Release, 2023, 363, 402-414.
3. Yuan Yao, Jing Tao, Jiayan Lyu, Cheng Chen, Yuan Huang, and Zhou Zhou*. Enhance Mitochondrial Damage by Nuclear Export Inhibition to Suppress Tumor Growth and Metastasis with Increased Antitumor Properties of Macrophages. ACS Appl. Mater. Interfaces 2023, 15, 20774−20787.
4. Chaohui Luo, Minglu Zhou, Cheng Chen, Shujie Li, Qiuyi Li, Yuan Huang, Zhou Zhou*. A liposome-based combination strategy using doxorubicin and a PI3K inhibitor efficiently inhibits pre-metastatic initiation by acting on both tumor cells and tumor-associated macrophages. Nanoscale, 2022, 14(12): 4573-4587.
5. Jiatao Yang, Qiuyi Li, Rui Zhou, Minglu Zhou, Xi Lin, Yucheng Xiang, Dandan Xie, Yuan Huang and Zhou Zhou*. Combination of mitochondria targeting doxorubicin with Bcl-2 function-converting peptide NuBCP-9 for synergistic breast cancer metastasis inhibition. Journal of Materials Chemistry B, 2021, 9(5): 1336-1350.
6. Jiatao Yang, Qiuyi Li, Minglu Zhou, Xiang Li, Yuan Huang, Nan Yang*, Zhou Zhou*. Concurrent impairment of nucleus and mitochondria for synergistic inhibition of cancer metastasis. International Journal of Pharmaceutics, 2021, 608: 121077.
7. Xiang Li#, Zhou Zhou#, Rui Zhou, Jiatao Yang, Minglu Zhou, Qiuyi Li, Lian Li, Yuan Huang*. Stimuli-Responsive Nanoparticles Combining Photodynamic Therapy and Mitochondria Disruption Suppressed Tumor Metastasis. Advanced Materials Interfaces, 2021: 2002200.
8. Qiuyi Li, Jiatao Yang, Cheng Chen, Xi Lin, Minglu Zhou, Zhou Zhou*, Yuan Huang*. A novel mitochondrial targeted hybrid peptide modified HPMA copolymers for breast cancer metastasis suppression. Journal of Controlled Release, 2020, 325: 38-51.
9. Yuanyuan Liu#, Zhou Zhou#, Xi Lin, Xiaofeng Xiong, Rui Zhou, Minglu Zhou, Yuan Huang*. Enhanced Reactive Oxygen Species Generation by MitochondriaTargeting of Anticancer Drug To Overcome Tumor Multidrug Resistance. Biomacromolecules, 2019, 20(10): 3755-3766.
10. Yanxi Liu, Qiuyi Li, Xiaofeng Xiong, Zhou Zhou*. Improved mitochondrial targeting effect of HPMA copolymer by SS20 peptide mediation and nonendocytosis pathway. Journal of Peptide Science, 2019, 25(2): e3144.
11. Yanxi Liu, Qiuyi Li, Xiaofeng Xiong, Yuan Huang and Zhou Zhou*. Mitochondria targeting and cell-penetrating peptides-co-modified HPMA copolymers for enhancing therapeutic efficacy of α-tocopheryl succinate. Journal of Materials, Chemistry B, 2018, 6(46): 7674-7683.
12. Yanxi Liu, Qiuyi Li, Xiaofeng Xiong, Yuan Huang and Zhou Zhou*. Enhanced cellular uptake by non-endocytic pathway for tumor therapy. Journal of Materials Chemistry B, 2018, 6(45): 7411-7419.
13. Fengling Wang, Lian Li, Wei Sun, Lijia Li, Yuanyuan Liu, Yuan Huang, Zhou Zhou*. A novel alpha(V) beta(3) ligand-modified HPMA copolymers for anticancer drug delivery. Journal of Drug Targeting, 2018, 26(3): 231-241.
14. Zhou Zhou, YanXi Liu, Lei Wu, Lian Li and Yuan Huang*. Enhanced nuclear delivery of anti-cancer drugs using micelles containing releasable membrane fusion peptide and nuclear-targeting retinoic acid. Journal of Materials Chemistry B, 2017, 5(34): 7175-7185.
15. Manling Tang, Minglu Zhou, Yuan Huang, Jiaju Zhong, Zhou Zhou* and Kui Luo*. Dual-sensitive and biodegradable core-crosslinked HPMA copolymer-doxorubicin conjugate-based nanoparticles for cancer therapy. Polymer Chemistry, 2017, 8(15): 2370-2380.
编辑：四川大学华西药学院
