孙逊 教授（博士，博士生导师）
单位：四川大学华西药学院药剂教研室
通讯地址：成都市人民南路三段17号四川大学华西药学院
电话/传真：（028）85502307
E-mail:sunxun@scu.edu.cn
简历
现任四川大学二级教授，博士生导师，药剂学系主任，国家杰出青年科学基金获得者，国家药典委员会委员，英国皇家学会牛顿高级学者，四川省高级留学回国人员。
1991.9-1996.7华西医科大学药学院本科
1996.8-2000.7 广州珠江医院
2000.9-2005.7 四川大学华西药学院攻读药剂学博士学位
2005.8-2007.2 美国宾夕法尼亚大学医学院博士后
2007.2-2008.9 美国密西根大学药学院博士后
2008.9-2012.6 四川大学华西药学院副研究员
2012.7-至今 四川大学华西药学院教授
研究方向
1.生物大分子药物高效递释系统。
2.靶向药物传递系统和分子药剂学。
学术兼职
·国家药典委员会委员（生物制品专业）
·中国药学会药剂专业委员会副主任委员
·美国基因和细胞治疗协会（ASGCT）官方杂志Molecular Therapy副主编
·国际控释协会官方杂志J. Controlled Release副主编
·国际控释协会（CRS）中国分会副主席
·四川省药学会常务理事
科研成果获奖情况：
1)2021年荣获国家科技进步奖二等奖，获奖题目：静脉注射用脂质类纳米药物制剂关键技术及产业化
2)2017年荣获树兰医学青年奖
3)2015年荣获四川省科技进步一等奖；获奖题目：中药新型给药系统的示范研究与应用
4)2015年荣获第三届四川省卫计委有突出贡献的中青年专家荣誉称号
5)2014年荣获成都市科学技术进步奖二等奖；获奖题目：中药新型给药系统的示范研究与应用
6)2012年获“中国药学会青年药剂奖”
7)2011年荣获第十一届四川省青年科技奖
8)2011年荣获四川省科技进步一等奖 （第3完成人）；获奖题目：针对多种器官组织或细胞的靶向释药系统的构建、表征及靶向特性研究
9)2008年获全国百篇优秀博士学位论文提名奖，获奖题目：静脉注射用治疗基因靶向传递系统研究
10)2006年荣获四川省科技进步三等奖（第2完成人）；获奖题目：治疗基因靶向传递系统的研究
主持的科研项目：
主持国家自然科学基金10项，国际合作项目4项，教育部新世纪优秀人才计划1项，国家科技重大专项子课题1项，四川省重大科技专项1项。
1. 国家自然科学基金联合基金项目（区域创新发展联合基金），U24A20811，亚单位疫苗和病毒载体疫苗新型递送系统的构建及其免疫增效机制的研究，2025.01-2028.12，260万元。
2.国家自然科学基金重点国际（地区）合作研究项目，82320108020，递送树突状细胞的新型双节微针用于肿瘤的免疫治疗，2024.01-2028.12，210万元。
3.国家自然科学基金杰出青年基金，81925036, 生物大分子药物递释系统，2020.01-2024.12，400万元。
4. 国家自然科学基金国际（地区）合作与交流项目，81961130395, 新型无痛缓释型乙肝
疫苗微针的基础开发及应用，2019.03-2022.02，49万元。
5. 国家自然科学基金面上项目，81872814，靶向淋巴结内树突状细胞的疫苗递送系统
用于类风湿性关节炎的治疗，2019.01-2022.12，57万元。
6. 四川省重大科技专项，2018SZDZX0018，基于可注射天然来源辅料的微粒递药系统
的构建及其应用，2018.07-2021.09，200万元。
7. 国家自然科学基金面上项目，81673362，克服免疫抑制屏障的多功能肿瘤疫苗载体
的构建及其机制研究，2017.01-2020.12，60万元。
8. 国家自然科学基金优秀青年基金，81422044，药剂学，2015.01-2017.12，100万元。
9. 国家自然科学基金面上项目，81173011，跨越肿瘤递送屏障的多功能腺病毒载体系统的研究，2012.01-2015.12，60万元。
10. 与英国中央兰开夏大学合作项目, 11H1554，Nanomedicines for Drug DeliveryApplications of anticancer small molecule, gene and protein，2011.11-2014.12，140万元。
11. 欧盟第七框架项目资助的科研项目，PIRSES-GA-2008-230791，Hyaluronan-basedinjectable material for tissue engineering，2009.09-2013.08，8.7万欧元。
Prof. Dr. Xun Sun
Key Laboratory of Drug-Targeting and Drug Delivery System, Ministry of Education
Department of Pharmaceutics
West China School of Pharmacy
Sichuan University, Chengdu 610041,China
Tel/Fax: (+86) 28 85502307
E-mail:sunxun@scu.edu.cn，xunsun22@gmail.com
Prof. Xun Sunis the dean of the Department of Pharmaceutics at Sichuan University with expertise in the targeted drug delivery systems and the delivery of biophar-maceuticals. After postdoctoral training at Perelman School of Medicine, University of Pennsylvania and the College of Pharmacy, University of Michigan, she joined the faculty of Sichuan University in 2008. She has served as the principal investi-gator for over 30 research projects worth over ¥40 million from National Natural Science Foundation of China, National Key Research and Development Program of China, British Royal Society, European Commission and Industry. She has pub-lished more than 300 papers with an h-index of 67, and ranks among the world's top 2% most-cited scientists for seven consecutive years.
Prof. Sun was the recipient of National Science Fund for Distinguished Young Scholars, the Newton Ad-vanced Fellowship, the second prize of National Scientific and Technological Progress Award and the first Prize of Sichuan Provincial Science and Technology Improvement Prize. Prof. Sun is serving as Section Editor of Molecular Therapy and Associate Editor of Journal of Controlled Release. Currently she is the President of the Chinese Local Chapter of Controlled Release Society (CRS) and Vice Chairman of the Pharmaceutical Committee of the Chinese Pharmaceutical Society.
Selected Publications（代表性论著）
More publication can be found inhttps://orcid.org/0000-0002-0218-1664
1.Yangsen Ou, Fuhua Wu, Chunting He, Shuang Luo, Zhaofei Guo, Yongshun Zhang, Rui Hu, Yanhua Xu, Xue Tang, Yuanhao Zhao, Lin Ye, Xiaoyan Chen, Shuting Bai, Guangsheng Du,Xun Sun, Modulating nuclear stiffness and envelope barrier facilitates AAV nuclear entry and reduces immunogenicity,Nature Communications, 2026, 17(1): 4549.
2.Rui Hu, Chengzheng You, Zhaofei Guo, Xiaoyan Zhu, Yanhua Xu, Yangsen Ou, Kun Xiong, Zhiqiang Xie, Guangsheng Du, Shuting Bai, Libing Hu, Xun Sun, Unified inactivation-mineralization: An engineered bacterial platform for synergistic radio-immunotherapy,Journal of Controlled Release, 2026, 397: 115150.
3.Shuting Bai, Yuan Xue, Chunting He, Kun Xiong, Tianyi Luo, Xue Tang, Yanhua Xu, Nan Qiao, Ming Qin, Xiaofang Zhong, Penghui He, Hongjiao Wei, Yangsen Ou, Guangsheng Du,Xun Sun, A Morphology-Driven Cascade Delivery of Antigens for Potent T Cell Immunity,Advanced Materials, 2026, 38(35): e73396.
4.Yanhua Xu, Xue Tang, Zhaofei Guo, Yuwei Wang, Chunting He, Hongjiao Wei, Yuan Xue, Yangsen Ou, Lin Ye, Yuanhao Zhao, Kun Xiong, Guangsheng Du, Yunzhu Lin, Shuting Bai,Xun Sun, Biomineralized nanoemulsion delivers mRNA for potent cancer immunotherapy,Journal of Controlled Release, 2026, 394: 114889.
5.Yongshun Zhang, Lan Yang, Yuxin Wang, Yingying Wang, Chengzheng You, Hairui Wang, Xiaojia Yang, Yunming Zhang, Zhiqiang Xie, Kun Xiong, Yangsen Ou, Guangsheng Du,Xun Sun, A ferroptosis-priming gene therapy for post-surgical cancer recurrence,Acta Pharmaceutica Sinica B, 2026.
6.Hairui Wang, Jinghong Xian, Guonian Zhu, Zhiqiang Xie, Guangsheng Du, Yongshun Zhang, Lan Yang, Yunming Zhang, Teng Li, Yehui Zhou, Weimin Li,Xun Sun, Chengdi Wang, Inhalational therapy of pulmonary infection via macrophage-targeted nanoemulsions,Acta Pharmaceutica Sinica B, 2026, 16(5): 3175-3190.
7.Zhiqiang Xie, Yunming Zhang, Xiaoyan Chen, Xiaofang Zhong, Hairui Wang, Mingxin Xie, Shuting Bai, Zhengjun Chen, Fan Fan, Yuandong Zhang,Xun Sun, NeutrophilGranule-Mimetic Emulsion Inducing GastrointestinalImmunity against Helicobacter pylori via Subcutaneous Vaccination,ACS Nano, 2025, 19(45): 39043-39061.
8.Xiaoyan Chen, Zhiqiang Xie, Ruinan Wu, Xiyue He, Ming Qin, Hairui Wang, Shuting Bai, Zhengjun Chen, Chunting He, Yangsen Ou, Yuanhao Zhao, Mingxin Xie, Yongshun Zhang, Guangsheng Du,Xun Sun, Liver-Targeted Tolerogenic Vaccines: A Nano-Membrane Coupled Approach for Autoimmune Disease Therapies,Advanced Materials, 2025, 37(35): 2507743.
9.Fuhua Wu, Zhaofei Guo, Jialiang Yang, Yangsen Ou, Xiejin Xie, Hu Liao, Chenqi Guo, Yuxi Zhan, Haiping Wu, Rui Hu, Yanhua Xu, Xue Tang, Haolin Wang, Lin Ye, Penghui He, Chunting He, Lu Huang, Shuang Luo,Xun Sun, Zhenglin Yang, A Universal Therapeutic Vaccine Leveraging Autologous Pre-Existing Immunity to Eliminate in Situ Uniformly Engineered Heterogeneous Tumor Cells,Advanced Materials, 2025, 37(9): 2412430.
10.Zhaofei Guo, Fuhua Wu, Chenqi Guo, Rui Hu, Yangsen Ou, Yining Zhu, Shuang Luo, Yuanshuai Song, Penghui He, Chunting He, Yanhua Xu, Xue Tang, Ming Qin, Hairui Wang, Guangsheng Du,Xun Sun, Metalloparticle-Engineered Pickering Emulsion Displaying AAV-Vectored Vaccine for Enhancing Antigen Expression and Immunogenicity Against Pathogens,Advanced Materials, 2025, 37(8): 2412627.
11.Chunting He, Penghui He, Yangsen Ou, Xue Tang, Hongjiao Wei, Yanhua Xu, Shuting Bai, Zhaofei Guo, Rui Hu, Kun Xiong, Guangsheng Du,Xun Sun, Rectifying the Crosstalkbetween the Skeletal andImmune Systems Improves Osteoporosis Treatment by Core–ShellNanocapsules,ACS Nano, 2025, 19(5): 5549-5567.
12.Shuang Luo, Hao Jiang, Qingwei Li, Yingfei Qin, Shiping Yang, Jing Li, Lingli Xu, Yan Gou, Yafei Zhang, Fengjiang Liu, Xiao Ke, Qiang Zheng,Xun Sun, An adeno-associated virus variant enabling efficient ocular-directed gene delivery across species,Nature Communications, 2024, 15(1): 3780.
13.Yuanhao Zhao, Xiaoyan Chen, Penghui He, Xuanyu Wang, Yanhua Xu, Rui Hu, Yangsen Ou, Zhihua Zhang, Zhibing Zhang, Guangsheng Du,Xun Sun, Transdermal Microneedles Alleviated Rheumatoid Arthritis by Inducing Immune Tolerance via Skin-Resident Antigen Presenting Cells,Small, 2024, 20(16): 2307366.
14.Hairui Wang, Shuang Luo, Mingxin Xie, Zhao Chen, Yunming Zhang, Zhiqiang Xie, Yongshun Zhang, Yu Zhang, Lan Yang, Fuhua Wu, Xiaoyan Chen, Guangsheng Du, Jincun Zhao,Xun Sun, ACE2 Receptor-Targeted Inhaled Nanoemulsions Inhibit SARS-CoV-2 and Attenuate Inflammatory Responses,Advanced Materials, 2024, 36(14): 2311537.
15.Yongshun Zhang, Lan Yang, Yangsen Ou, Rui Hu, Guangsheng Du, Shuang Luo, Fuhua Wu, Hairui Wang, Zhiqiang Xie, Yu Zhang, Chunting He, Cheng Ma, Tao Gong, Ling Zhang, Zhirong Zhang,Xun Sun, Combination of AAV-delivered tumor suppressor PTEN with anti-PD-1 loaded depot gel for enhanced antitumor immunity,Acta Pharmaceutica Sinica B, 2024, 14(1): 350-364.
