黄园教授(博士，博士生导师)
单位：四川大学华西药学院药剂系
通讯地址：成都市人民南路三段17号四川大学华西药学院
电话/传真：（028）85501617
E-mail:hyuan@aliyun.com
简历
1989-1993 华西医科大学药学院，获理学学士学位
1993-1996 华西医科大学药学院，获药剂学硕士学位
2000-2003 四川大学华西药学院，获药剂学博士学位
1996- 四川大学华西药学院药剂系任助教、讲师、副教授、教授
2001-2002 美国马里兰大学药学院药剂学教研室访问学者
任职及学术兼职
中国药学会第二十五届理事会理事、中国药学会药学教育专业委员会副主任委员、全国药学专业学位研究生教育指导委员会委员、中国抗癌协会第三届纳米肿瘤学专业委员会常务委员、四川省药学会副理事长。担任"Asian J. Pharm."杂志副主编和"药学学报"杂志编委，人卫社《药剂学》副主编，中国医药出版社《药剂学》编委。
研究方向
1、靶向给药系统的构建及其作用机制研究：包括生物大分子药物黏膜递药系统的研究；亚细胞靶向递药系统的研究
2、药物新剂型、新制剂的研究
主要研究课题
1、基于“表面性质-主动靶向”交互作用的多肽蛋白类药物递送系统的跨黏膜转运调控（国家自然科学基金区域创新发展联合基金，编号：U22A20356，起止日期：2023.1-2026.12，负责人）。
2、模拟肠道营养物质吸收的口服高效递药系统的研究（国家重点研发计划中国和新西兰政府间国际科技创新合作项目，编号：2021YFE0115200，起止日期：2022.1-2024.12，负责人）
3、克服组织和细胞屏障的高效递药系统的构建与机制研究（国家自然科学基金杰出青年基金，编号：81625023，起止日期：2017.1-2021.12，负责人）。
获奖情况
1、静脉注射用脂质类纳米药物制剂关键技术及产业化。国家科学技术进步二等奖。2021，排名第六
2、多肽蛋白类药物口服高效递释系统基础研究，教育部高等学校自然科学一等奖。2019，排名第一
3、四川省学术技术带头人，2023
4、四川省三八红旗手标兵，2022
5、国务院政府特殊津贴，2019
6、四川大学 "探究式-小班化"教学质量优秀奖
7、四川大学第五届“德沃群芳”育人文化建设优秀团队，2019
代表性论著
1.KongJinxia, DengYudi, XuYiwen, ZhangPing, LiLian,HuangYuan*. A Two-pronged Delivery Strategy Disrupting Positive Feedback Loop of Neutrophil Extracellular Traps for Metastasis Suppression. ACS nano，2024，18 (24), 15432-15451
2.Yinglan Yu, Mingjie Ni, Yaxian Zheng, Yuan Huang. Airway epithelial-targeted nanoparticle reverses asthma in inhalation therapy. Journal of Controlled Release, 2024,367, 223-234
3.Liyun Xing, Xi Liu, Licheng Wu, Jiawei Wu, Yudi Deng, Qiuyi Li, Zhou Zhou, Lian Li, Yuan Huang*. Orally Hierarchical Targeting Delivery Systems Relieve Colitis by Protecting Host Mitochondria and Modulating Gut Microbiota. Nano Today, 2024,55, 102155
4.Qingting Zuo; Jiayan Lyu; Xinran Shen; Fengju Wang; Liyun Xing; Minglu Zhou; Zhou Zhou; Lian Li; Yuan Huang*. A Less-is-More Strategy for Mitochondria-Targeted Photodynamic Therapy of Rheumatoid Arthritis. Small, 2024, 2307261
5.Xinran Shen, Liqiang Chen, Chendong Liu, Lian Li,* and Yuan Huang*. Modulation of Autophagy Direction to Enhance Antitumor Effect of Endoplasmic- Reticulum-Targeted Therapy: Left orRight? Adv. Sci. 2023, 2301434
6.Jiawei Wu, Liyun Xing, YaxianZheng, Yinglan Yu, Ruinan Wu, Xi Liu, Lian Li, and Yuan Huang*. Disease-Specific Protein Corona Formed in Pathological Intestine Enhances the Oral Absorption of Nanoparticles. Acta Pharm Sin B. 2023, 13, 3876-3891
7.Yinglan Yu, Shujie Li, Yuan Yao, Xinran Shen, Lian Li, Yuan Huang*.Increasing stiffness promotes pulmonary retention of ligand-directed dexamethasone-loaded nanoparticle for enhanced acute lung inflammation therapy. Bioactive Materials, 2023;20:539-547
8.Liqiang Chen, Peihang Jiang, Xinran Shen, Jiayan Lyu, Chendong Liu, Lian Li, and Yuan Huang*.Cascade Delivery to Golgi Apparatus and On-Site Formation of Subcellular Drug Reservoir for Cancer Metastasis Suppression. Small 2022, 2204747
9.Qiuyi Li, Cheng Chen, Jinxia Kong, Lian Li, Junlin Li, Yuan Huang*. Stimuli-Responsive Nano Vehicle Enhances Cancer Immunotherapy by Coordinating Mitochondria-Targeted Immunogenic Cell Death and PD-L1 Blockade. Acta Pharm Sin B.2022;12(5):2533-2549
10.ChendongLiu,LianLi,JiayanLyu,YuchengXiang,LiqiangChen,ZhouZhou,YuanHuang*. Split Bullets Loaded Nanoparticles for Amplified Immunotherapy. Journal of Controlled Release, 2022;347:199-210
11.Lei Wu#, Lingling Wang#, Xi Liu, YuliBai, Ruinan Wu, Xiang Li, Yutong Mao, Ling Zhang, YongxiangZheng, Tao Gong, Zhirong Zhang and Yuan Huang*. Milk-Derived Exosomes Exhibit Versatile Effects for Improved Oral Drug Delivery. Acta Pharm Sin B. 2022;12(4):2029-2042
12.Shujie Li, Lian Li, Xi Lin, Cheng Chen, ChaohuiLuo, and Yuan Huang*.Targeted Inhibitionof Tumor Inflammation and Tumor-Platelet Crosstalk by Nanoparticle-Mediated Drug Delivery Mitigates Cancer Metastasis. ACS nano. 2022;16(1):50-67
13.Yinglan Yu, LiYun Xing, Lian Li, Jiawei Wu, Jinhan He, Yuan Huang*. Coordination of rigidity modulation and targeting ligand modification on orally-delivered nanoparticles for the treatment of liver fibrosis. Journal of Controlled Release. 2022;341:215-226
14.Xiaoli Yi , Yue Yan , Lian Li , Rui Zhou , Xinran Shen , Yuan Huang *. Combination of mitochondria impairment and inflammation blockade to combat metastasis. Journal of Controlled Release. 2022;341:753–768
15.Liqiang Chen, Chendong Liu, Yucheng Xiang, JiayanLyu, Zhou Zhou, Tao Gong, Huile Gao, Lian Li*, Yuan Huang*. Exocytosis Blockade of Endoplasmic Reticulum-Targeted Nanoparticle Enhances Immunotherapy. Nano Today. 2021;42:101356
