杨劲松教授（博士生导师）
单位：四川大学华西药学院天然药物学系
通信地址：成都市人民南路三段17号四川大学华西药学院（610041）
E-mail：yjs@scu.edu.cn, yjscd@163.com
学习和研究工作简历
杨劲松教授，四川大学化学专业学士（1992年）、南开大学有机化学理学硕士（1995年）、华西医科大学药物化学理学博士（1998年），日本东邦大学药学部药物化学博士后（1998年12月-1999年12月）。从1998年9月至今，在四川大学任教，历任助教、讲师、副教授，现为华西药学院教授、博士生导师、天然药物学系主任。担任中国化学会糖化学专业委员会委员、中国疫苗行业协会糖疫苗专业委员会委员、国际碳水化合物期刊《J. Carbohydr. Chem.》编委，《四川大学学报（医学版）》编委。研究兴趣聚焦于糖链高效合成领域的关键科学问题和技术瓶颈，开展复杂寡糖合成的基础和应用研究。以通讯作者在JACS、Angew等国际顶级和本领域权威期刊发表论文40余篇。申请发明专利5项，获授权3项。主持国家级、省部级科研项目共12项，参与国家基金委创新群体、科技部十二五重大新药创制专项等项目共4项。
获得的学术奖励和人才称号
四川省学术和技术带头人（2024）
四川省卫生健康领军人才（2021）
教育部新世纪优秀人才（2008）
四川省杰出青年基金（2008）
首届中国化学会糖化学贡献奖（2021）
亚洲核心计划学术报告奖（ACP Lectureship Award）（2018）
第五届“阿达玛斯”学术论文奖（2018）
四川大学第八届“姜维平优秀教学奖”二等奖（2022）
四川大学优秀博士学位论文指导教师奖（2022）
研究兴趣：
新的糖化学合成方法和策略的发展
细菌细胞壁糖缀合物、肿瘤相关糖抗原的合成和活性评价
基于糖类的新药发现
近期发表论文
1. Jin-Song Yang*, Yu-Xiong Ruan, Hong-Yang Wang, Ling Li, Yan-Li Zhao, Yong Qin, Effect of Protecting Groups and Activating Conditions on 3-Deoxy-D-glycero-D-galacto-2-nonulosonic Acid (Kdn) Glycosylation: Stereoselective Synthesis of α- and β‑Kdn Glycosides, 2024, https://doi.org/10.1021/acs.orglett.4c04325.
2. Sheng Luo, Zhuo-Jia Xu, Xia Wang, Xiao-Qing Hu, Ke Shang, Zhen Zhang, Chao He, Yong Qin, Jin-Song Yang*, Divergent Synthesis and Antigenicity Evaluation of Core Oligosaccharides of the Lipopolysaccharides from Acinetobacter baumannii SMAL and ATCC 19606, Org. Lett. 2024, 26, 8069-8073.
3. Yuanyuan Jiang, Shichao Duan, Jiaming Li, Yanli Zhao, Jinsong Yang*, Chemical and chemoenzymatic syntheses of sialyl Lewisa tetrasaccharide antigen, Org. Biomol. Chem., 2024, 22, 5776-5782.
4. Ling Li, Xiao-Chen Yin, Yuan-Yuan Jiang, Yi-Fei Xia, Xia Wang, Jiao Li, Hong Li, Yong Qin, Jin-Song Yang*, Chemical Synthesis of a Branched Nonasaccharide Fragment from Helicobacter pylori Lipopolysaccharide, Org. Lett. 2024, 26, 2103-2107.
5. Su-Jia Li, Qing Fang, Ying-Wen Huang, Yi-Yang Luo, Xiao-Dong Mu, Ling Li, Xiao-Chen Yin, and Jin-Song Yang*, Chemical Synthesis of the Nonreducing Hexasaccharide Fragment of Axinelloside A Based on a Stepwise Glycosylation Approach, Org. Lett. 2022, 24, 7088-7094.
6. Xian-Yang Zhou, Ling-Xin Li, Zhen Zhang, Shi-Chao Duan, Ying-Wen Huang, Yi-Yang Luo, Xiao-Dong Mu, Zhi-Wei Chen, Yong Qin, Jing Hu, Jian Yin, Jin-Song Yang*, Chemical Synthesis and Antigenic Evaluation of Inner Core Oligosaccharides from Acinetobacter baumannii Lipopolysaccharide, Angew. Chem. Int. Ed. 2022, 61, e202204420.
7. Jin-Cai Lei, Yuan-Yuan Jiang, Yi-Fei Xia, Qing Fang, Shi-Chao Duan, Yu-Xiong Ruan, Jin-Song Yang*, Stereoselective Synthesis of a Tetrasaccharide Fragment from Rhamnogalacturonan II Side Chain A, Chin. J. Chem. 2022, 40, 1799-1806.
8. Xing-Ling Pan, Lei Huang, Yan Zeng, Chun-Yun Xu, Dong-Mei Liu, Yue Chu, Yong Qin, Jin-Song Yang*. Synthesis of an Unusual Hexasaccharide Repeating Unit from the Cell Wall Polysaccharide of Eubacterium saburreum strain T19, Org. Chem. Front. 2020, 7, 2298.
9. Dong-Mei Liu, Hong-Ling Wang, Jin-Cai Lei, Xian-Yang Zhou, Jin-Song Yang*. A Highly α-Stereoselective Sialylation Method Using 4-O-4-Nitropicoloyl Thiosialoside Donor, Eur. J. Org. Chem. 2020, 575.
10. Yan Zeng and Jin-Song Yang*. Stereoselective Synthesis of a Tetrasaccharide Fragment from Cellulosome Produced by Clostridium thermocellum, Asian J. Org. Chem. 2020, 9, 317.
11. Jin-Cai Lei, Yu-Xiong Ruan, Sheng Luo, Jin-Song Yang*. Stereodirecting Effect of C3-Ester Groups on the Glycosylation Stereochemistry of L-Rhamnopyranose Thioglycoside Donors: Stereoselective Synthesis of α- and -L-Rhamnopyranosides, Eur. J. Org. Chem. 2019, 6377.
12. Xian-Yang Zhou, Pan Yang, Sheng Luo, and Jin-Song Yang*. Divergent Synthesis of 3-Deoxy-D-manno-oct-2-ulosonic Acid (Kdo) Glycosides Containing α-(2→4)-Linked Kdo-Kdo Unit, Chem. Asian J. 2019, 14, 454.
13. Wei Huang, Ying-Yu Zhou, Xing-Ling Pan, Xian-Yang Zhou, Jin-Cai Lei, Dong-Mei Liu, Yue Chu, Jin-Song Yang*. Stereodirecting Effect of C5-Carboxylate Substituents on the Glycosylation Stereochemistry of 3‑Deoxy-D-manno-oct-2-ulosonic Acid (Kdo) Thioglycoside Donors: Stereoselective Synthesis of α- and β‑Kdo Glycosides, J. Am. Chem. Soc. 2018, 140, 3574.
14. Yuan Xu, Hua-Chao Bin, Fu Su, Jin-Song Yang*. Stereoselective synthesis of aryl 1,2-cis-furanosides and its application to the synthesis of the carbohydrate portion of antibiotic hygromycin A, Tetrahedron Lett. 2017, 58, 1548.
15. Peng-Cheng Gao, San-Yong Zhu, Hui Cao, Jin-Song Yang*. Total Synthesis of Marine Glycosphingolipid Vesparioside B, J. Am. Chem. Soc. 2016, 138, 1684.
16. Kai Zhu, Jin-Song Yang*. Synthesis of tri- and tetrasaccharide glycosides of (4S)-4-hydroxy-D-proline relevant to the cell wall O-glycans of green alga Chlamydomonas reinhardtii, Tetrahedron 2016, 72, 3113.
17. Jia-Sheng Huang, Wei Huang, Xue Meng, Xin Wang, Peng-Cheng Gao, Jin-Song Yang*. Stereoselective Synthesis of α-3-Deoxy-D-manno-oct-2-ulosonic Acid (α-Kdo) Glycosides Using 5,7-O-Di-tert-butylsilylene-Protected Kdo Ethyl Thioglycoside Donors, Angew. Chem. Int. Ed. 2015, 54, 10894.
18. Shuai Wang, Xue Meng, Wei Huang, Jin-Song Yang*. Study on the Influence of Silyl Protections on the Anomeric Reactivity of Galactofuranosyl Thioglycosides and Application of the Silylated Thiogalactofuranosides to One-Pot Synthesis of Diverse β-D-Oligogalactofuranosides, J. Org. Chem. 2014, 79, 10203.
19. San-Yong Zhu, Jia-Sheng Huang, Shan-Shan Zheng, Kai Zhu, Jin-Song Yang*. First Total Synthesis of the Proposed Structure of Batatin VI, Org. Lett. 2013, 15, 4154.
20. Qiang-Wei Liu, Hua-Chao Bin, Jin-Song Yang*. β-Arabinofuranosylation Using 5-O-(2-Quinolinecarbonyl) Substituted Ethyl Thioglycoside Donors, Org. Lett. 2013, 15, 3974.
21. Xing-Yong Liang, Hua-Chao Bin, Jin-Song Yang*. Tuning Effect of Silyl Protecting Groups on the Glycosylation Reactivity of Arabinofuranosyl Thioglycoside, Org. Lett. 2013, 15, 2834.
22. Xing-Yong Liang, Qiang-Wei Liu, Hua-Chao Bin, Jin-Song Yang*. One-Pot Synthsis of Branched Oligosaccharide by Use of Galacto- and Mannopyranosyl Thioglycoside Diols as Key Glycosylating Agent, Org. Biomol. Chem. 2013, 11, 3903.
23. Xing-Yong Liang, Li-Ming Deng, Jin-Song Yang*. Review on Synthesis and Occurrence of Oligoaranbino-, Oligogalacto- and Oligofructo furanoses, Chin. J. Org. Chem. 2013, 33, 245.
24. Jia Shao, Jin-Song Yang*. A Diastereoselective Cyclic Imine Cycloaddition Strategy to Access Polyhydroxylated Indolizidine Skeleton: Concise Syntheses of (+)-/(–)-Lentiginosines and (–)-2-epi-Steviamine, J. Org. Chem. 2012, 77, 7891.
25. San-Yong Zhu, Jin-Song Yang*. Synthesis of Tetra- and Hexasaccharide Fragments Corresponding to the O-Antigenic Polysaccharide of Klebsiella Pneumoniae, Tetrahedron 2012, 68, 3795.
26. Li-Min Deng, Xia Liu, Xing-Yong Liang, Jin-Song Yang*. Regioselective Glycosylation Method Using Partially Protected Arabino- and Galactofuranosyl Thioglycosides as Key Glycosylating Substrates and Its Application to One-Pot Synthesis of Oligofuranoses, J. Org. Chem. 2012, 77, 3025.
27. Lin Xie, San-Yong Zhu, Xiao-Qiu Shen, Li-Li He, Jin-Song Yang*. Total Synthesis of Batatoside L, J. Org. Chem. 2010, 75, 5764.
