通讯地址：成都市人民南路三段17号四川大学华西校区华西药学院（邮编610041）
电子邮箱:yancheng@scu.edu.cn
简历
2016/09-2018/09斯坦福大学，医学院，访问学者
2012/09-至今四川大学，华西药学院，教学科研
2009/04-2012/03京都大学，药学院，博士
2004/09-2007/06四川大学，华西药学院，硕士
2000/09-2004/07四川大学，华西药学院，学士
学术团体任职
1.中国医药生物技术协会药物分析技术分会委员会常务委员
2.中国药理学会分析药理学专业委员会委员
3.中国药理学会分析药理学专业委员会青年委员会常务委员
4.四川省色谱学会委员
5.Journal of Pharmaceutical Analysis青年编委
研究方向
分子成像技术在医药研发中的应用，具体包括：
1.生物靶点分析与药物筛选
2.药代动力学与药效学研究
3.分子影像探针与诊疗一体化药物
主持的科研项目
1)国家自然科学基金（81402891）
2)教育部博士点新教师基金（20130181120114)
3）四川省自然科学基金（2023NSFSC1721）
4）四川省卫生和计划生育委员会普及应用项目（16PJ225）
5）四川大学优秀青年学者基金（2015SCU04A37）
指导的学生科研项目
1）国家级大学生创新训练计划（201610610125）
2）四川省大学生创新训练计划（201510610327）
3）四川大学本科创新训练计划（201610611296）
4）四川大学本科创新训练计划（201510611139）
荣誉奖项
1）国家级一流本科课程《体内药物分析与毒物分析》（线上线下混合式）
2）全国高等学校药学类专业青年教师微课教学大赛一等奖（药物分析组）
3）全国高等学校药学类专业青年教师教学能力大赛二等奖（药物分析组）
4）全国药物分析大会优秀论文优秀奖
5）全国药物分析大会优秀论文二等奖
6）四川大学青年骨干教师奖
7）四川大学基于智慧教学环境“探究式-小班化”教学质量优秀奖
8）四川大学华西药学院本科优秀教学奖
9）四川大学华西药学院本科优秀教学三等奖
10）四川大学本科优秀毕业论文（设计）三等奖（曹敏）（指导教师）
11）四川大学本科优秀毕业论文（设计）三等奖（曹思雨薇）（指导教师）
12）四川大学本科优秀毕业论文（设计）三等奖（李文君）（指导教师）
13）四川大学本科优秀毕业论文（设计）三等奖（朱必越）（指导教师）
14）四川大学本科优秀毕业论文（设计）三等奖（李雪）（指导教师）
15）四川大学本科优秀毕业论文（设计）三等奖（邓越）（指导教师）
代表性论著
1.Jiajun Wu,Meiting Mao,Jie Yang,Kexin Li,Pengxin Deng,Jing Zhong,Xiaoai Wu*,Yan Cheng*.Development of an18F-labeled azobenzothiazole tracer for α-synuclein aggregates in the brain.Org Biomol Chem.2024, 22, 4550-4558.
2.Jiajun Wu,Kexin Li,Jie Yang,Meiting Mao,Yan Cheng*.Radiolabeled imaging agents for Alzheimer’s disease.iRADIOLOGY.2023, 2, 80-95.
3.Qinyu Wang,Jing Zhong,Kexin Li,Jiajun Wu,Xiaoxue Wang,Shen Jiang,Jiapei Dai,Yan Cheng*.Compact luminol chemiluminophores for in vivo detection and imaging of β-Sheet Protein Aggregates.Anal. Chem.2023,95, 1065-1073.
4.Biyue Zhu,Jing Yang,Richard Van,Fan Yang,Yue Yu,Astra Yu,Kathleen Ran,Keyi Yin,Yingxia Liang,Xunuo Shen,Wei Yin,Se Hoon Choi,Ying Lu,Changning Wang,Yihan Shao,Liang Shi,Rudolph E Tanzi,Can Zhang*,Yan Cheng*,Zhirong Zhang,Chongzhao Ran*.Epitope alteration by small molecules and applications in drug discovery.Chem. Sci.2022, 13, 8104-8116.
5.Jing Ma,Xiaoxue Wang,Na Li,Yan Cheng*.A bifunctional probe that allows dual-channel fluorescence turn-on detection of protein aggregates and hydrogen peroxide in neurodegenerative diseases.Sens. Actuators B Chem.2021,346,130536.
6.Wanyun Li, Jing Ma, Qian Jiang, Ting Zhang, Qingrong Qi*,Yan Cheng*.Fast Noninvasive Measurement of Brown Adipose Tissue in Living Mice by Near-Infrared Fluorescence and Photoacoustic Imaging.Anal. Chem.2020, 92(5), 3787-3794.
7.BiyueZhu,TingZhang,QianJiang, Ying Li, Yu Fu, Jiapei Dai, Ge Li, Qingrong Qi*,Yan Cheng*. Synthesis and evaluation of pyrazine and quinoxaline fluorophores for in vivo detection of cerebral tau tangles in Alzheimer’s models.Chem. Commun. (Camb).2018, 54(82), 11558-11561.
8.Zhu BY,Cheng Y*,Li GB,Yang SY,Zhang ZR*. Synthesis and evaluation of styrylpyran fluorophores for noninvasive detection of cerebral β-amyloid deposits.Bioorg Med Chem.2016 Feb 15;24(4):827-34.
9.YanCheng*,BiyueZhu,YueDeng,ZhirongZhang*.In vivo detection of cerebral amyloid fibrils with smart dicynomethylene-4H-pyran-based fluorescence probe.Anal. Chem.2015, 87(9), 4781-4787.
10.Cheng Y,*Zhu BY,Li X,Li GB,Yang SY,Zhang ZR*.Bioorg. Med. Chem. Lett.2015, 25(20):4472-6. doi: 10.1016/j.bmcl.2015.08.081.
11.MasahiroOno*,YanCheng, HiroyukiKimura, HiroyukiWatanabe, KenjiMatsumura, MasashiYoshimura, ShimpeiIikuni, YokoOkamoto, MasafumiIhara, RyosukeTakahashi, HideoSaji.Development of Novel (123)I-Labeled Pyridyl Benzofuran Derivatives for SPECT Imaging of β-Amyloid Plaques in Alzheimer's Disease.PLoS One.，8(9):e74104, 2013.
12.Yan Cheng, Masahiro Ono*, Hiroyuki Kimura, Masashi Ueda, Hideo Saji.Technetium-99m Labeled Pyridyl Benzofuran Derivatives as Single Photon Emission Computed Tomography Imaging Probes for β-Amyloid Plaques in Alzheimer’s Brains.J. Med. Chem.55(5), 2279-2286, 2012
13.Masahiro Ono*,Yan Cheng, Hiroyuki Kimura, Mengchao Cui, Shinya Kagawa, Ryuichi Nishii, Hideo Saji*.Novel18F-Labeled Benzofuran Derivatives with Improved Properties for Positron Emission Tomography (PET) Imaging of β-Amyloid Plaques in Alzheimer's Brains.J. Med. Chem.54(8), 2971-2979, 2011
14.Yan Cheng, Masahiro Ono*, Hiroyuki Kimura, Shinya Kagawa, Ryuichi Nishii, Hideo Saji*.Fluorinated Benzofuran Derivatives for PET Imaging of β-Amyloid Plaques in Alzheimer's Disease Brains.ACS Med. Chem. Lett.1(7), 321-325, 2010
15.Yan Cheng, Masahiro Ono*, Hiroyuki Kimura, Shinya Kagawa, Ryuichi Nishii, Hideo Saji*.A Novel18F-Labeled Pyridyl Benzofuran Derivative for Imaging of β-Amyloid Plaques in Alzheimer's Brains.Bioorg. Med. Chem. Lett.20(20), 6141–6144, 2010
16.Masahiro Ono*, Manami Ishikawa, Hiroyuki Kimura, Shun Hayashi, Kenji Matsumura, Hiroyuki Watanabe, Yoichi Shimizu,Yan Cheng, Mengchao Cui, Hidekazu Kawashima, Hideo Saji*,Development of Dual Functional SPECT/Fluorescent Probes for Imaging Cerebral β-amyloid Plaques.Bioorg. Med. Chem. Lett.20(13), 3885–3888, 2010
17.Masahiro Ono*, Rumi Watanabe, Hidekazu Kawashima,Yan Cheng, Hiroyuki Kimura, Hiroyuki Watanabe,Mamoru Haratake, Hideo Saji, Morio Nakayama*,Fluoro-pegylated Chalcones as Positron Emission Tomography Probes for in vivo Imaging of β-amyloid Plaques in Alzheimer's Disease.J. Med. Chem.52(20), 6394–6401, 2009.
