张媛媛 副教授（硕士生导师）
通讯地址：成都市人民南路三段十七号四川大学华西药学院药理学教研室
Email: zhangyy@scu.edu.cn
教育及工作经历：
2001年毕业于中国药科大学，获学士学位；2006年毕业于中国科学院上海生命科学研究院，获博士学位。2006-2007年于香港大学医学院内科系担任助理研究员。2007-2010年在复旦大学生命科学学院任教，2010年调入四川大学华西基础医学与法医学院。2016-2017年于美国 University of Pennsylvania访学。2021年调入华西药学院。
主要研究方向及领域：
主要从事激素调控代谢的机制研究，从代谢异常引起的氧化应激器官损伤和免疫调节角度，探寻心血管、肝脏、皮肤等代谢异常诱发疾病的治疗靶点及药物作用机制。依托四川大学药学院建立代谢药理学实验室，具备代谢异常疾病动物模型和细胞模型等完备的科研体系。研究团队包括科研助理、研究生（包含联合培养）、进修医生等十余人。
实验室目标是培养代谢药理学领域的优秀青年科研/研发人才，为他们打好学术基础，并在他们的职业发展中持续提供支持，使他们成为生物医学的顶尖人才！
学术兼职：
中国药理学会化疗药理专委会委员、网络药理学专委会委员，中国抗癌协会肿瘤胃肠病学专委会、肿瘤标志专委会委员，中国医学促进会徇证医学分会委员，四川省药理学会理事，四川省抗癌协会肿瘤标志专委会委员等。
主要获奖情况：
四川省学术与技术带头人后备人选（2020年）
四川大学“十佳青年教师教学奖”（2019年）
四川大学“大学生创新创业与实践教育优秀指导教师”（2019年）
主持科研项目：
国家自然科学基金面上项目（82170844）
四川省放射肿瘤学重点实验室开放基金（2020FSZLX-02）
近五年发表的部分科研论文：
1. Yang Y., Wu Y., Zou J., Wang Y.H., Xu M.X., Huang W., Yu D.J., Zhang L.,Zhang Y.Y.*, Sun X.D.*, Naringenin Attenuates Non-Alcoholic Fatty Liver Disease by Enhancing Energy Expenditure and Regulating Autophagy via AMPK. Front Pharmacol, 2021. 12: 687095.
2. Wu, Y., Y. Yang, F. Li, J. Zou, Y.-H. Wang, M.-X. Xu, Y.-L. Wang, R.-X. Li, Y.-T. Sun, S. Lu, Y.-Y. Zhang, and X.-D. Sun, Icaritin Attenuates Lipid Accumulation by Increasing Energy Expenditure and Autophagy Regulated by Phosphorylating AMPK. J Clin Transl Hepatol, 2021.9(3):373-383.
3. Wang, Y.L., J. Wu, R.X. Li, Y.T. Sun, Y.J. Ma, C.Y. Zhao, J. Zou, Y.Y. Zhang, and X.D. Sun, A double-edged sword: The Kelch-like ECH-associated protein 1-nuclear factor erythroid-derived 2-related factor 2-antioxidant response element pathway targeted pharmacological modulation in nonalcoholic fatty liver disease. Curr Opin Pharmacol, 2021. 60: 281-290.
4. Zhang, P., T. Li, X. Wu, E.C. Nice, C. Huang, and Y. Zhang, Oxidative stress and diabetes: antioxidative strategies. Front Med-PRC, 2020. 14(5): 583-600.
5. Tao, C.C., Y. Yang, F. Li, L. Qiao, Y. Wu, X.D. Sun, Y.Y. Zhang, and C.L. Li, Cloning short DNA into plasmids by one‐step PCR. Thoracic Cancer, 2020. 11. 3409-3415.
6. Tao, C.C., Y. Wu, X. Gao, L. Qiao, Y. Yang, F. Li, J. Zou, Y.H. Wang, S.Y. Zhang, C.L. Li, Y.Y. Zhang, and X.D. Sun, The antitumor effects of icaritin against breast cancer is related to estrogen receptors. Curr Mol Med, 2020. 21(1): 73-85.
7. Peng, L., J. Jiang, B. Tang, E.C. Nice, Y.Y. Zhang, and N. Xie, Managing therapeutic resistance in breast cancer: from the lncRNAs perspective. Theranostics, 2020. 10(23): 10360-10377.
8. Zhang, Z., L. Zhang, L. Zhou, Y.L. Lei, Y.Y. Zhang, and C.H. Huang, Redox signaling and unfolded protein response coordinate cell fate decisions under ER stress. Redox Biol, 2019. 25. 101047.
9. Xu, K., B. Han, Y. Bai, X.Y. Ma, Z.N. Ji, Y. Xiong, S.K. Miao, Y.Y. Zhang, and L.M. Zhou, MiR-451a suppressing BAP31 can inhibit proliferation and increase apoptosis through inducing ER stress in colorectal cancer. Cell Death & Dis, 2019. 10. 152.
10. Tian, X., S. Chen, Y. Zhang, L. Chen, X. Guo, Z. Xu, H. Liu, P. Hu, Z. Chen, Z. Li, and C. Huang, Absorption, liver first-pass effect, pharmacokinetics and tissue distribution of calycosin-7-O-ss-d-glucopyranoside (C7G) and its major active metabolite, calycosin, following oral administration of C7G in rats by LC-MS/MS. J Pharm Biomed Anal, 2018. 148: 350-354.
11. Liu, Y., W. Ren, Y. Bai, L. Wan, X. Sun, Y. Liu, W. Xiong, Y.Y. Zhang, and L. Zhou, Oxyresveratrol prevents murine H22 hepatocellular carcinoma growth and lymph node metastasis via inhibiting tumor angiogenesis and lymphangiogenesis. J Nat Med, 2018. 72(2): 481-492.
12. Liao, Q.J., Y.Y. Zhang, Y.C. Fan, M.H. Zheng, Y. Bai, G.D. Eslick, X.X. He, S.B. Zhang, H.H.X. Xia, and H. He, Perceptions of Chinese Biomedical Researchers Towards Academic Misconduct: A Comparison Between 2015 and 2010. Sci Eng Ethics, 2018. 24(2): 629-645.
13. Han, B., Y.Y. Zhang, K. Xu, Y. Bai, L.H. Wan, S.K. Miao, K.X. Zhang, H.W. Zhang, Y. Liu, and L.M. Zhou, NUDCD1 promotes metastasis through inducing EMT and inhibiting apoptosis in colorectal cancer. Am J Cancer Res, 2018. 8(5): 810-823.
14. Han, B., D. Feng, X. Yu, Y.Y. Zhang, Y.Q. Liu, and L.M. Zhou, Identification and Interaction Analysis of Molecular Markers in Colorectal Cancer by Integrated Bioinformatics Analysis. Med Sci Monit, 2018. 24: 6059-6069.
15. Xu, K., Y.Y. Zhang, B. Han, Y. Bai, Y. Xiong, Y. Song, and L.M. Zhou, Suppression subtractive hybridization identified differentially expressed genes in colorectal cancer: microRNA-451a as a novel colorectal cancer-related gene. Tumor Biol, 2017. 39(5).
16. Wu, Y., Y. Song, Y. Xiong, X. Wang, K. Xu, B. Han, Y. Bai, L. Li, Y. Zhang, and L. Zhou, MicroRNA-21 (Mir-21) Promotes Cell Growth and Invasion by Repressing Tumor Suppressor PTEN in Colorectal Cancer. Cell Physiol Biochem, 2017. 43(3): 945-958.
17. Shi, X., H. Zhu, Y. Zhang, M. Zhou, D. Tang, and H. Zhang, XuefuZhuyu decoction protected cardiomyocytes against hypoxia/reoxygenation injury by inhibiting autophagy. BMC Complement Altern Med, 2017. 17(1): 325.
18. Zhu, J.J., X. Chen, Y. Song, Y.Y. Zhang, L.M. Zhou, and L.H. Wan, Deficit of RACK1 contributes to the spatial memory impairment via upregulating BECLIN1 to induce autophagy. Life Sci, 2016. 151: 115-121.
19. Liu, Z.R., Y. Song, L.H. Wan, Y.Y. Zhang, and L.M. Zhou, Over-expression of miR-451a can enhance the sensitivity of breast cancer cells to tamoxifen by regulating 14-3-3 zeta, estrogen receptor alpha, and autophagy. Life Sci, 2016. 149: 104-113.
