何金汗 教授（博士生导师）
单位：四川大学华西医院/华西药学院
通讯地址：成都市武侯区国学巷37号
电话/传真：（028）85164128
E-mail: jinhanhe@scu.edu.cn
简历
教育经历:
2002/09 - 2007/07: 北京大学，博士学位 / 博士学历，
1997/09 - 2002/07: 北京大学，医学本科
工作经历:
2021/11 – 现今: 四川大学华西药学院临床药学与药事管理学系，主任
2021/11 – 现今: 四川大学华西医院药学部，主任
2013/07 – 2021/10: 四川大学华西医院药学部，副主任
2012/10 – 现今: 四川大学华西医院药学部，教授
2007/09 – 2012/10: 美国匹兹堡大学， 博士后
主要社会职务
1. 中国药理学会肾脏药理专委会委员
2. 中华医学会临床药学分会青年委员
3. 四川省药学会药学流行病学专委会副主任委员
4. 四川省预防医学会静配专委会副主任委员
人才称号
四川省卫生健康“首席专家”
四川省学术和技术带头人
四川省卫健委学术和技术带头人
四川大学青年骨干教师
研究方向
内分泌药理学，老年人合理用药
主要研究课题
1. 国家杰出青年科学基金，2021/01至2025/12，在研，主持
2. 国家自然科学基金重点项目，2020/01至2024/12，在研，主持
3. 国家自然科学基金面上项目，2015/01至2018/12，已结题，主持
4. 四川省杰出青年基金2014/01至2016/12，已结题，主持
5. 国家自然科学基金面上项目，2013/01至2016/12，已结题，主持
6. 四川大学优秀青年学者， 2013/01至2014/12，已结题，主持
7. 美国心脏病学会资助项目，2009/07至2011/07，已结题，主持
主要研究成果
1. Huang C, Liu Q, Tang Q, Jing X, Wu T, Zhang J, Zhang G, Zhou J, Zhang Z, Zhao Y, Huang H, Xia Y, Yan J, Xiao J*, Li Y*, He J*. Hepatocyte-specific deletion of Nlrp6 in mice exacerbates the development of non-alcoholic steatohepatitis. Free Radic Biol Med. 2021 Apr 12: S0891-5849(21)00210-0.
2. Zhou J, Li R, Liu Q, Zhang J, Huang H, Huang C, Zhang G, Zhao Y, Wu T, Tang Q, Huang Y, Zhang Z, Li Y*, He J*. Blocking 5-LO pathway alleviates renal fibrosis by inhibiting the epithelial-mesenchymal transition. Biomed Pharmacother. 2021 Mar 12;138: 111470.
3. Zhang G, Liu Q, Li Y, Huang C, Zhou J, Zhao Y, Wu T, Tang Q, Li R, Zhang Z, Zhang J, Huang Y, Huang H, Xia Y, Yan J, Jing X, He J*. Mesencephalic astrocyte-derived neurotrophic factor alleviates alcohol induced hepatic steatosis via activating Stat3-mediated autophagy. Biochem Biophys Res Commun. 2021 Apr 23;550:197-203. (IF=2.98）
4. Zhou J, Li R, Zhang J, Liu Q, Wu T, Tang Q, Huang C, Zhang Z, Huang Y, Huang H, Zhang G, Zhao Y, Zhang T, Mo L, Li Y*, He J*. Targeting interstitial myofibroblast-expressed integrin αvβ3 alleviates renal fibrosis. Mol Pharm. 2021 Mar 1;18(3):1373-1385.
5. Wu T, Liu Q, Li Y, Li H, Chen L, Yang X, Tang Q, Pu S, Kuang J, Li R, Huang Y, Zhang J, Zhang Z, Zhou J, Huang C, Zhang G, Zhao Y, Zou M, Jiang W, Mo L*, He J*. Feeding-induced hepatokine, Manf, ameliorates diet-induced obesity by promoting adipose browning via p38 MAPK pathway. J Exp Med. 2021 Jun 7;218(6):e20201203.
6. Pu S, Li Y, Liu Q, Zhang X, Chen L, Li R, Zhang J, Wu T, Tang Q, Yang X, Zhang Z, Huang Y, Kuang J, Li H, Zou M, Jiang W, He J*. Inhibition of 5-lipoxygenase in hepatic stellate cells alleviates liver fibrosis. Front Pharmacol. 2021 Feb 18;12:628583.
7. Tang Q, Liu Q, Yang X, Wu T, Huang C, Zhang J, Zhang Z, Zhang G, Zhao Y, Zhou J, Huang H, Xia Y, Yan J, Li Y, He J*. Sirtuin 6 supra-physiological overexpression in hypothalamic pro-opiomelanocortin neurons promotes obesity via the hypothalamus-adipose axis. FASEB J. 2021 Mar;35(3):e21408.
8. Zhang J, Li Y, Liu Q, Huang Y, Li R, Wu T, Zhang Z, Zhou J, Huang H, Tang Q, Huang C, Zhao Y, Zhang G, Jiang W, Mo L, Zhang J, Xie W, He J*. Sirt6 alleviated liver fibrosis by deacetylating conserved lysine 54 on Smad2 in hepatic stellate cells. Hepatology. 2021 Mar;73(3):1140-1157.
9. Zhang Z, Du Z, Liu Q, Wu T, Tang Q, Zhang J, Huang C, Huang Y, Li R, Li Y, Zhao Y, Zhang G, Zhou J, Huang H, Fang Z*, He J*. Glucagon-like peptide 1 analogue prevents cholesterol gallstone formation by modulating intestinal farnesoid X receptor activity. Metabolism. 2021 Feb 11;118:154728.
10. Yang X, Liu Q, Li Y, Ding Y, Zhao Y, Tang Q, Wu T, Chen L, Pu S, Cheng S, Zhang J, Zhang Z, Huang Y, Li R, Zhao Y, Zou M, Shi X, Jiang W, Wang R*, He J*. SGLT2 inhibition by canagliflozin ameliorates diet-induced obesity by promoting intra-adipose sympathetic innervation. Br J Pharmacol. 2021 Apr;178(8):1756-1771.
11. Zhang T, Li Y, Song Y, Chen X, Li J, Peng Q, He J, Fei X. Curcumin- and cyclopamine-loaded liposomes to enhance therapeutic efficacy against hepatic fibrosis. Drug Des Devel Ther. 2020 Dec 23; 14:5667-5678.
12. Zhang J, Li R, Liu Q, Zhou J, Huang H, Huang Y, Zhang Z, Wu T, Tang Q, Huang C, Zhao Y, Zhang G, Mo L, Li Y*, He J*. SB431542-Loaded Liposomes Alleviate Liver Fibrosis by Suppressing TGF-β Signaling. Mol Pharm. 2020 Nov 2;17(11):4152-4162
13. Yang X, Liu Q, Li Y, Tang Q, Wu T, Chen L, Pu S, Zhao Y, Zhang G, Huang C, Zhang J, Zhang Z, Huang Y, Zou M, Shi X, Jiang W, Wang R*, He J*. The diabetes medication canagliflozin promotes mitochondrial remodeling of adipocyte via the AMPK-Sirt1-Pgc-1α signaling pathway. Adipocyte. 2020 Dec;9(1):484-494.
14. Tang Q, Gao Y, Liu Q, Yang X, Wu T, Huang C, Huang Y, Zhang J, Zhang Z, Li R, Pu S, Zhang G, Zhao Y, Zhou J, Huang H, Li Y, Jiang W, Chang Y*, He J*. Sirt6 in pro-opiomelanocortin neurons controls energy metabolism by modulating leptin signaling. Mol Metab. 2020 Apr 9:100994.
15. Huang Y, Li Y, Liu Q, Zhang J, Zhang Z, Wu T, Tang Q, Huang C, Li R, Zhou J, Zhang G, Zhao Y, Huang H, He J*. Telmisartan attenuates obesity-induced insulin resistance via suppression of AMPK mediated ER stress. Biochem Biophys Res Commun. 2020 Mar 12;523(3):787-794.
16. Li R, Li Y, Zhang J, Liu Q, Wu T, Zhou J, Huang H, Tang Q, Huang C, Huang Y, Zhang Z, Zhang G, Zhao Y, Ma L, Feng Y, Mo L, Han M*, He J*. Targeted delivery of celastrol to renal interstitial myofibroblasts using fibronectin-binding liposomes attenuates renal fibrosis and reduces systemic toxicity. J Control Release. 2020 Jan 10;320:32-44.
17. Pu S, Liu Q, Li Y, Li R, Wu T, Zhang Z, Huang C, Yang X, He J*. Montelukast Prevents Mice Against Acetaminophen-Induced Liver Injury. Front Pharmacol. 2019 Sep 18;10:1070.
18. Li Y, Zhang T, Liu Q, He J*. PEG-derivatized dual-functional nanomicelles for improved cancer therapy. Front Pharmacol. 2019 Jul 19;10:808.
19. Li Y, Zhang T, Liu Q, Zhang J, Li R, Pu S, Wu T, Ma L, He J*. Mixed micelles loaded with the 5-benzylidenethiazolidine-2,4-dione derivative SKLB023 for efficient treatment of non-alcoholic steatohepatitis. Int J Nanomedicine. 2019 May 28;14:3943-3953.
20. Li H, Shen J, Wu T, Kuang J, Liu Q, Cheng S, Pu S, Chen L, Li R, Li Y, Zou M, Zhang Z, Jiang W, Qu A, He J*. Irisin is controlled by farnesoid x receptor and regulates cholesterol homeostasis. Front Pharmacol. 2019 May 28;10:548.
21. Yan J, Tung HC, Li S, Niu Y, Garbacz WG, Lu P, Bi Y, Li Y, He J, Xu M, Ren S, Monga SP, Schwabe RF, Yang D, Xie W. Aryl hydrocarbon receptor signaling prevents activation of hepatic stellate cells and liver fibrogenesis in mice. Gastroenterology. 2019 Sep;157(3):793-806.e14.
22. Li Y, Pu S, Liu Q, Li R, Zhang J, Wu T, Chen L, Li H, Yang X, Zou M, Xiao J, Xie W*, He J*. An integrin-based nanoparticle that targets activated hepatic stellate cells and alleviates liver fibrosis. J Control Release. 2019 Jun 10;303:77-90.
23. Mao Z, Lin H, Su W, Li J, Zhou M, Li Z, Zhou B, Yang Q, Zhou M, Pan K, He J*, Zhang W*. Deficiency of ZnT8 promotes adiposity and metabolic dysfunction by increasing peripheral serotonin production. Diabetes. 2019 Jun;68(6):1197-1209.
24. Xiao J, Wang F, Wong NK, He J, Zhang R, Sun R, Xu Y, Liu Y, Li W, Koike K, He W, You H, Miao Y, Liu X, Meng M, Gao B, Wang H, Li C. Global liver disease burdens and research trends: Analysis from a Chinese perspective. J Hepatol. 2019 Jul;71(1):212-221.
25. Li R, Wang X, Wu S, Wu Y, Chen H, Xin J, Li H, Lan J, Xue K, Li X, Zhuo C, He J, Tang CS, Jiang W. Irisin ameliorates angiotensin II-induced cardiomyocyte apoptosis through autophagy. J Cell Physiol. 2019 Aug;234(10):17578-17588.
26. Liu Q, Pu S, Chen L, Shen J, Cheng S, Kuang J, Li H, Wu T, Li R, Jiang W, Zou M, Zhang Z, Li Y, Li J*, He J*. Liver-specific Sirtuin6 ablation impairs liver regeneration after 2/3 partial hepatectomy. Wound Repair Regen. 2019 Jul;27(4):366-374.
27. Chen L, Liu Q, Tang Q, Kuang J, Li H, Pu S, Wu T, Yang X, Li R, Zhang J, Zhang Z, Huang Y, Li Y, Zou M, Jiang W, Li T, Gong M, Zhang L, Wang H, Qu A, Xie W*, He J*. Hepatocyte-specific Sirt6 deficiency impairs ketogenesis. J Biol Chem. 2019 Feb 1;294(5):1579-1589.
28. Kuang J, Chen L, Tang Q, Zhang J, Li Y, He J*. The role of Sirt6 in obesity and diabetes. Front Physiol. 2018 Feb 27;9:135.
29. Cheng S, Zou M, Liu Q, Kuang J, Shen J, Pu S, Chen L, Li H, Wu T, Li R, Li Y, Jiang W, Zhang Z*, He J*. Activation of constitutive androstane receptor prevents cholesterol gallstone formation. Am J Pathol. 2017 Apr;187(4):808-818.
30. Kuang J, Zhang Y, Liu Q, Shen J, Pu S, Cheng S, Chen L, Li H, Wu T, Li R, Li Y, Zou M, Zhang Z, Jiang W, Xu G, Qu A, Xie W, He J*. Fat-specific sirt6 ablation sensitizes mice to high-fat diet-induced obesity and insulin resistance by inhibiting lipolysis. Diabetes. 2017 May;66(5):1159-1171.
31. Li H, Pu S, Liu Q, Huang X, Kuang J, Chen L, Shen J, Cheng S, Wu T, Li R, Li Y, Mo L, Jiang W, Song Y*, He J. Potentially inappropriate medications in Chinese older adults: The beers criteria compared with the screening tool of older persons' prescriptions criteria. Geriatr Gerontol Int. 2017 Nov;17(11):1951-1958.
32. Wu T, Zhang F, Yang Q, Zhang Y, Liu Q, Jiang W, Cao H, Li D, Xie S, Tong N*, He J*. Circulating mesencephalic astrocyte-derived neurotrophic factor is increased in newly diagnosed prediabetic and diabetic patients, and is associated with insulin resistance. Endocr J. 2017 Apr 29;64(4):403-410.
33. Li Y, Li R, Liu Q, Li W, Zhang T, Zou M, Li H, Wu T, Cheng S, Su Z, Zhang Z, He J*. One-step self-assembling nanomicelles for pirarubicin delivery to overcome multidrug resistance in breast cancer. Mol Pharm. 2016 Nov 7;13(11):3934-3944.
34. Li Y, Liu Q, Li W, Zhang T, Li H, Li R, Chen L, Pu S, Kuang J, Su Z, Zhang Z, He J*. Design and validation of peg-derivatized vitamin e copolymer for drug delivery into breast cancer. Bioconjug Chem. 2016 Aug 17;27(8):1889-99.
35. Mo L, Shen J, Liu Q, Zhang Y, Kuang J, Pu S, Cheng S, Zou M, Jiang W, Jiang C, Qu A, He J*. Irisin is regulated by car in liver and is a mediator of hepatic glucose and lipid metabolism. Mol Endocrinol. 2016 May;30(5):533-42.
36. Pu S, Ren L, Liu Q, Kuang J, Shen J, Cheng S, Zhang Y, Jiang W, Zhang Z, Jiang C, He J*. Loss of 5-lipoxygenase activity protects mice against paracetamol-induced liver toxicity. Br J Pharmacol. 2016 Jan;173(1):66-76.
37. Jiang M, Klein M, Zanger UM, Mohammad MK, Cave MC, Gaikwad NW, Dias NJ, Selcer KW, Guo Y, He J, Zhang X, Shen Q, Qin W, Li J, Li S, Xie W. Inflammatory regulation of steroid sulfatase: A novel mechanism to control estrogen homeostasis and inflammation in chronic liver disease. J Hepatol. 2016 Jan;64(1):44-52.
38. Zhao X, Gao M, He J, Zou L, Lyu Y, Zhang L, Geng B, Liu G, Xu G. Perilipin1 deficiency in whole body or bone marrow-derived cells attenuates lesions in atherosclerosis-prone mice. PLoS One. 2015 Apr 9;10(4):e0123738.
39. He J#*, Xu C#, Kuang J, Liu Q, Jiang H, Mo L, Geng B, Xu G*. Thiazolidinediones attenuate lipolysis and ameliorate dexamethasone-induced insulin resistance. Metabolism. 2015 Jul;64(7):826-36. #，共同第一作者
40. Cheng Q, Inaba Y, Lu P, Xu M, He J, Zhao Y, Guo GL, Kuruba R, de la Vega R, Evans RW, Li S, Xie W. Chronic activation of FXR in transgenic mice caused perinatal toxicity and sensitized mice to cholesterol toxicity. Mol Endocrinol. 2015 Apr;29(4):571-82.
41. Mo L, Yang X, He J, Dong B. Evaluation of potentially inappropriate medications in older inpatients in China. J Am Geriatr Soc. 2014 Nov;62(11):2216-8.
42. Mo L, He J*. Nuclear hormone receptors PXR and CAR and metabolic diseases. Horm Mol Biol Clin Investig. 2014 Aug;19(2):129-40.
43. Mo L, He Q, Wang Y, Dong B, He J*. High prevalence of obstructive sleep apnea in Marfan's syndrome. Chin Med J (Engl). 2014;127(17):3150-5.
44. Jiang M, He J, Kucera H, Gaikwad NW, Zhang B, Xu M, O'Doherty RM, Selcer KW, Xie W. Hepatic overexpression of steroid sulfatase ameliorates mouse models of obesity and type 2 diabetes through sex-specific mechanisms. J Biol Chem. 2014 Mar 21;289(12):8086-97.
45. Shi X, Cheng Q, Xu L, Yan J, Jiang M, He J, Xu M, Stefanovic-Racic M, Sipula I, O'Doherty RM, Ren S, Xie W. Cholesterol sulfate and cholesterol sulfotransferase inhibit gluconeogenesis by targeting hepatocyte nuclear factor 4α. Mol Cell Biol. 2014 Feb;34(3):485-97.
46. He J, Hu B, Shi X, Weidert ER, Lu P, Xu M, Huang M, Kelley EE, Xie W. Activation of the aryl hydrocarbon receptor sensitizes mice to nonalcoholic steatohepatitis by deactivating mitochondrial sirtuin deacetylase Sirt3. Mol Cell Biol. 2013 May;33(10):2047-55.
47. He J, Gao J, Xu M, Ren S, Stefanovic-Racic M, O'Doherty RM, Xie W. PXR ablation alleviates diet-induced and genetic obesity and insulin resistance in mice. Diabetes. 2013 Jun;62(6):1876-87.
48. Gao J, He J, Shi X, Stefanovic-Racic M, Xu M, O'Doherty RM, Garcia-Ocana A, Xie W. Sex-specific effect of estrogen sulfotransferase on mouse models of type 2 diabetes. Diabetes. 2012 Jun;61(6):1543-51.
49. He J, Lee JH, Febbraio M, Xie W. The emerging roles of fatty acid translocase/CD36 and the aryl hydrocarbon receptor in fatty liver disease. Exp Biol Med. 2011 Oct;236(10):1116-21.
50. He J, Nishida S, Xu M, Makishima M, Xie W. PXR prevents cholesterol gallstone disease by regulating biosynthesis and transport of bile salts. Gastroenterology. 2011 Jun;140(7):2095-106.
51. Lee JH, Wada T, Febbraio M, He J, Matsubara T, Lee MJ, Gonzalez FJ, Xie W. A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosis. Gastroenterology. 2010 Aug;139(2):653-63.
52. He J, Cheng Q, Xie W. Minireview: Nuclear receptor-controlled steroid hormone synthesis and metabolism. Mol Endocrinol. 2010 Jan;24(1):11-21.
53. Gong H#, He J#, Lee JH, Mallick E, Gao X, Li S, Homanics GE, Xie W. Activation of the liver X receptor prevents lipopolysaccharide-induced lung injury. J Biol Chem. 2009 Oct 30;284(44):30113-21. #，共同第一作者
54. Gao J, He J, Zhai Y, Wada T, Xie W. The constitutive androstane receptor is an anti-obesity nuclear receptor that improves insulin sensitivity. J Biol Chem. 2009 Sep 18;284(38):25984-92.
55. Liu MJ, Takahashi Y, Wada T, He J, Gao J, Tian Y, Li S, Xie W. The aldo-keto reductase Akr1b7 gene is a common transcriptional target of xenobiotic receptors pregnane X receptor and constitutive androstane receptor. Mol Pharmacol. 2009 Sep;76(3):604-11.
56. Xu C, He J, Jiang H, Zu L, Zhai W, Pu S, Xu G. Direct effect of glucocorticoids on lipolysis in adipocytes. Mol Endocrinol. 2009 Aug;23(8):1161-70.
57. Xie Y, Ke S, Ouyang N, He J, Xie W, Bedford MT, Tian Y. Epigenetic regulation of transcriptional activity of pregnane X receptor by protein arginine methyltransferase 1. J Biol Chem. 2009 Apr 3;284(14):9199-205.
58. Zu L, He J, Jiang H, Xu C, Pu S, Xu G. Bacterial endotoxin stimulates adipose lipolysis via toll-like receptor 4 and extracellular signal-regulated kinase pathway. J Biol Chem. 2009 Feb 27;284(9):5915-26.
59. He J, Xie W. Nuclear xenobiotic receptors: integrating gene regulation to physiological functions. Prog Mol Biol Transl Sci. 2009;87:87-116.
60. Zhang T, He J, Xu C, Zu L, Jiang H, Pu S, Guo X, Xu G. Mechanisms of metformin inhibiting lipolytic response to isoproterenol in primary rat adipocytes. J Mol Endocrinol. 2009 Jan;42(1):57-66.
61. Zhou J, Febbraio M, Wada T, Zhai Y, Kuruba R, He J, Lee JH, Khadem S, Ren S, Li S, Silverstein RL, Xie W. Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARγ in promoting steatosis. Gastroenterology. 2008 Feb;134(2):556-67.
62. Zu L, Jiang H, He J, Xu C, Pu S, Liu M, Xu G. Salicylate blocks lipolytic actions of tumor necrosis factor-alpha in primary rat adipocytes. Mol Pharmacol. 2008 Jan;73(1):215-23.
63. Jiang H, He J, Pu S, Tang C, Xu G. Heat shock protein 70 is translocated to lipid droplets in rat adipocytes upon heat stimulation. Biochim Biophys Acta. 2007 Jan;1771(1):66-74.
64. Ren T, He J, Jiang H, Zu L, Pu S, Guo X, Xu G. Metformin reduces lipolysis in primary rat adipocytes stimulated by tumor necrosis factor-alpha or isoproterenol. J Mol Endocrinol. 2006 Aug;37(1):175-83.
65. He J, Jiang H, Tansey JT, Tang C, Pu S, Xu G. Calyculin and okadaic acid promote perilipin phosphorylation and increase lipolysis in primary rat adipocytes. Biochim Biophys Acta. 2006 Feb;1761(2):247-55.
编写教材与专著
1. 何金汗，《高等药理学》，编委，人民卫生出版社，2021
2. 何金汗，《系统内分泌学》，编委，科学出版社，2021
3. 何金汗，《临床药理学（英文版）》，副主编，人民卫生出版社，2021
4. He J and Xie W. Gallstones: Recent advance in epidemiology, pathogenesis, diagnosis and management, Nova Science Publishers, 2016
5. He J and Xie W. Nuclear Xenobiotic Receptors: Integrating Gene Regulation to Physiological Functions. In Progress in Molecular Biology and Translational Science (Vol. 87) (Ed. Chakravarti D.), pp87-116, Academic Press (2009) ISBN:978-0-12-374760-0
