贾知军 研究员（博士生导师）
通信地址：成都市人民南路三段十七号，四川大学华西药学院
电子邮箱：zhijun_jia@scu.edu.cn
简历：
2020-至今 四川大学，研究员
2018-2020 美国加州理工学院，博士后，师从Frances H. Arnold教授（美国三院院士，2018诺贝尔化学奖得主）
2017-2018 德国马克斯•普朗克分子生理所，博士后，师从Herbert Waldmann院士
2012-2016 德国多特蒙德工业大学，化学生物学专业，博士，师从Herbert Waldmann院士
2009-2012 四川大学，药物化学专业，硕士，师从陈应春教授
2005-2009 四川大学，生物技术基地班，市场营销（第二专业），本科
研究内容：
针对天然酶难以满足科学与产业需求的挑战性难题，致力于非天然酶功能创制与产业化研究（Bioworks beyond nature）。面向产学研一体化与“十五五”生物制造战略定位，融合人工智能与定向进化策略，开发非天然酶催化及生物合成新方法，从而实现高价值功能分子的绿色生物制造。
累计发表学术论文40余篇，总引用数超过2600次，H指数为20，相关成果被Nature Catalysis, Synfact, Chemistry Views等国际知名期刊与学术媒体亮点报道。入选国家海外高层次人才引进计划，承担“绿色生物制造”“中药现代化”国家重点研发计划子课题等国家级、省部级科研项目4项，申请并获受理专利20余项，其中授权中国发明专利6项，专有技术成果转化1项。产业实践方面，创办四川艾合智兴生物科技有限公司，聚焦非天然酶技术研发与产业转化，赋能传统产业升级，公司获批成都市首批概念验证中心（活性分子生物合成）、国家高新技术企业等平台与资质认定。
代表性论文：
(1) Liu, X.-Q.‡; Li, R.‡; Chen, J.-L.; Li, Y.; Wei, L.; Wu, H.; Li, L.; Chen, B.-H.; Wu, Y.; Liu, S.-J.; Lin, G.-X.; Zhang, J.-F.; Zheng, Y.; Zhang, C.; Yang, Y.-F.; Wang, X.*; Chen, P.*; Jia, Z.-J.* Reprogramming Imine Reductases for Enantioselective Reduction of Electron-Rich Enamides. JACS Au 2026, 6, 955−964.
(2) He, H.; Yan, J.-X.; Zhu, J.-X.; Liu, S.-J.; Liu, X.-Q.; Chen, P.*; Wang, X.*; Jia, Z.-J.* Enantioselective Trifluoromethylazidation of Styrenyl Olefins Catalyzed by an Engineered Nonheme Iron Enzyme. Angew. Chem. Int. Ed. 2025, 64, e202423507.
(3) Wang, Z.-Y.; Ma, X.-Y.; Wu, Y.; Liu, Y.; Lin, G.-X.; Liu, X.-Q.; Zhang, C.; Chen, P.*; Zheng, Y.*; Jia, Z.-J.* Engineering Unspecific Peroxygenases for Enantioselective α-Hydroxylation of β-Ketoesters. Angew. Chem. Int. Ed. 2025, 64, e202509359.
(4) Liu, F.‡; Li, S.-Y.‡; Fan, Z.-S.; Luo, J.-H.; Zeng, X.; Wei, L.; Li, Y.; Li, J.-Y.; Zheng, Y.; Wang, X.; Zhang, C.*; Chen, P.*; Jia, Z.-J.* Directed Evolution of Nonheme Iron Enzymes for Enantioselective Aminative Difunctionalization of Alkenes. JACS Au 2025, 5, 4472−4480.
(5) Liu, Y.; Chen, Y.; Zhao, Y.-J.; Zhang, G.-Q.; Zheng, Y.; Yu, P.*; Chen, P.*; Jia, Z.-J.* Iron-Catalyzed Primary Amination of C(sp³)–H Bonds. J. Am. Chem. Soc. 2024, 146, 24863−24870.
(6) Jia, Z.-J.; Gao, S.; Arnold, F. H. Enzymatic Primary Amination of Benzylic and Allylic C(sp³)-H Bonds. J. Am. Chem. Soc. 2020, 142, 10279−10283.
(7) Jia, Z.-J., Shan, G., R., Daniliuc, C. G., Antonchick, A. P.,* Waldmann, H.* Enantioselective Synthesis of the Spirotropanyl Oxindole Scaffold throughBime-x-tallic Relay Catalysis. Angew. Chem. Int. Ed. 2018, 57, 14493-14497.
(8) Jia, Z.-J., Takayama, H., Futamura, Y., Aono, H., Bauer, J. O., Strohmann, C., Antonchick, A. P.*, Osada, H.*, Waldmann, H.* Catalytic EnantioselectiveSynthesis of a Pyrrolizidine–Alkaloid-Inspired Compound Collection withAntiplasmodial Activity. J. Org. Chem. 2018, 13, 7033-7041.
(9) Jia, Z.-J., Merten, C., Knauer, L., Murarka, S., Strohmann, C., Waldmann, H.* Biology-Oriented Synthesis of Decahydro-4,8-epoxyazulene Scaffolds. Synlett 2017, 28, 2918-2922.
(10) Jia, Z.-J., Merten, C., Gontla, R., Daniliuc, C. G., Antonchick, A. P.,* Waldmann, H.* General Enantioselective C‒H Activation with Efficiently TunableCyclopentadienyl Ligands. Angew. Chem. Int. Ed. 2017, 56, 2429-2434.
(11) Jia, Z.-J., Daniliuc, C. G., Antonchick, A. P.,* Waldmann, H.* Phosphine-Catalyzed Dearomatizing [3+2] Annulations of Isoquinolinium Methylides with Allenes. Chem. Commun. 2015, 51, 1054-1057.
(12) Jia, Z.-J., Jiang, K., Zhou, Q.-Q., Dong, L., Chen, Y.-C.* Amine-N-Heterocyclic Carbene Cascade Catalysis for the Asymmetric Synthesis of Fused Indane Derivatives with Multiple Chiral Centres. Chem. Commun. 2013, 49, 5892-5894.
(13) Jia, Z.-J., Zhou, Q., Zhou, Q.-Q., Chen, P.-Q., Chen, Y.-C.* exo-Selective Asymmetric Diels–Alder Reaction of 2,4-Dienals and Nitroalkenes by Trienamine Catalysis. Angew. Chem. Int. Ed. 2011, 50,8638-8641.
(14) Jia, Z.-J., Jiang, H., Li, J.-L.,Gschwend, B., Li, Q.-Z., Yin, X., Grouleff, J., Chen, Y.-C.,* Jørgensen,K. A.* Trienamines in Asymmetric Organocatalysis: Diels−Alder and Tandem Reactions. J. Am. Chem. Soc. 2011,133,5053-5061.
