黄园 教授 (博士生导师)

黄园教授 (博士，博士生导师)                 

单位：四川大学华西药学院药剂系

通讯地址：成都市人民南路三段17号四川大学华西药学院

电话/传真：（028）85501617

E-mail:hyuan@aliyun.com

简历

1989-1993  华西医科大学药学院，获理学学士学位

1993-1996  华西医科大学药学院，获药剂学硕士学位

2000-2003  四川大学华西药学院，获药剂学博士学位

1996-　　   四川大学华西药学院药剂系任助教、讲师、副教授、教授

2001-2002  美国马里兰大学药学院药剂学教研室访问学者

任职及学术兼职

　　中国药学会纳米药物专委会委员、中国药学会药学教育专业委员会副主任委员、全国药学专业学位研究生教育指导委员会委员、四川省药学会副理事长。担任"Asian J. Pharm."杂志副主编和"药学学报"杂志编委。

研究方向  

1、靶向给药系统的构建及其作用机制研究：包括口服胃肠道定位释药系统的研究；口服蛋白多肽类药物给药系统的研究；肿瘤靶向给药系统的研究

2、药物新剂型、新制剂的研究

主要研究课题及研究成果

1、可促进药物经肠道细胞摄取和出胞的口服纳米递药系统的研究（国家自然科学基金面上项目，编号：81872818，起止 日期：2019.1-2022.12，负责人）。

2、克服组织和细胞屏障的高效递药系统的构建与机制研究（国家自然科学基金杰出青年基金，编号：81625023，起止日期：2017.1-2021.12，负责人）。

3、肿瘤细胞核靶向HPMA聚合物给药系统的研究（国家自然科学基金面上项目，编号：81473167，起止日期：2015.1-2018.12，负责人）。

获奖情况

1、 多肽蛋白类药物口服高效递释系统基础研究，教育部高等学校自然科学一等奖。2019，排名第一

2、 国务院政府特殊津贴，2019

3、四川大学 "探究式-小班化"教学质量优秀奖

4、第3批国家"高端人才"科技创新领军人才，2018

5、倡导个性化教育，积极激发学生潜能——药学专业教学模式改革。四川省第八届高等教育优秀教学成果三等奖，2018，排名第一

代表性论著

1.Lei Wu, Yuli Bai, Lingling Wang, Xi Liu, Rui Zhou, Lian Li, Ruinan Wu, Zhirong Zhang, Xi Zhu, Yuan Huang*. Promoting apical-to-basolateral unidirectional transport of nanoformulations by manipulating the nutrient-absorption pathway. J. Control. Release.. 2020, 323: 151-160

2.Yucheng Xiang#，Liqiang Chen，Lian Li*, Yuan Huang*. Restoration and Enhancement of Immunogenic Cell Death of Cisplatin by Coadministration with Digoxin and Conjugation to HPMA Copolymer. ACS Appl. Mater. Interfaces. 2020,12(1):1606-1616

3.Minglu Zhou, Lijia Li, Lian Li, Xi Lin, Fengling Wang, Qiuyi Li, Yuan Huang*. Overcoming chemotherapy resistance via simultaneous drug-efflux circumvention and mitochondrial targeting. Acta Pharmaceutica Sinica B. 2019;9(3):615-625    

4.Yaxian Zheng, Jiawei Wu, Wei Shan, Lei Wu, Rui Zhou, Min Liu, Yi Cui, Minglu Zhou, Zhirong Zhang, and Yuan Huang*. Multifunctional Nanoparticles Enable Efficient Oral Delivery of Biomacromolecules via Improving Payload Stability and Regulating the Transcytosis Pathway. ACS Appl. Mater. Interfaces, 2018, 10, 34039-34049

5.Jiawei Wu, Yaxian Zheng, Min Liu, Wei Shan, Zhirong Zhang, and Yuan Huang*. Biomimetic Viruslike and Charge Reversible Nanoparticles to Sequentially Overcome Mucus and Epithelial Barriers for Oral Insulin Delivery. ACS Appl. Mater. Interfaces, 2018, 10, 9916-9928.

6.Yining Xu#, YaxianZheng,#, LeiWu,XiZhu,ZhirongZhang,YuanHuang*.A Novel Solid Lipid Nanoparticle with Endosomal Escape Function for Oral Delivery of Insulin. ACS Appl Mater Interfaces. 2018;10(11):9315-9324

7.Lei Wu, Wei Shan, Zhirong Zhang and Yuan Huang*.Engineering nanomaterials to overcome the mucosal barrier by modulating surface properties. Advanced Drug Delivery Reviews. 2018;124;150-163

8.Wang, Fengling; Sun, Wei; Li, Lian; Li, Lijia; Liu, Yuanyuan; Zhang, Zhirong; Huang, Yuan*. Charge-reversible Multi-functional HPMA Copolymers for Mitochondrial Targeting. ACS Appl Mater Interfaces. 2017, 9(33): 27563-27574

9.Lei Wu,Min Liu,Wei Shan,Xi Zhu,Lijia Li,Zhirong Zhang,Yuan Huang*.Bioinspired butyrate-functionalized nanovehicles for targeted oral delivery of biomacromolecular drugs. J. Control. Release. 2017;262:273-283

10.Qingqing Yang#, Lei Wu#, Lian Li, Zhou Zhou and Yuan Huang*. Subcellular co-delivery of two different site-oriented payloads for tumor therapy. Nanoscale, 2017, 9, 1547 - 1558

11.Lijia Li, Wei Sun, Lian Li, Yuanyuan Liu, Lei Wu, Fengling Wang, Zhou Zhou, Zhirong Zhang,and Yuan Huang*. A pH-responsive Sequential-disassembly Nanohybrid For Mitochondrial Targeting. Nanoscale, 2017, 9, 314–325

12.Lian Li, Wei Sun, Zhirong Zhang, and Yuan Huang*. Time-staggered delivery of docetaxel and H1-S6A, F8A peptide for sequential dual-strike chemotherapy through tumor priming and nuclear targeting. J. Control. Release. 2016;232:62-74

13.Xi Zhu#, Jun Wu#, Wei Shan,Zhou Zhou, Min Liu,Yuan Huang*. Sub-50 nm Nanoparticles with Biomimetic Surfaceto Sequentially Overcome theDiffusion Barrier of Mucus and Absorption Barrier of Epithelium. Adv. Funct. Mater. 2016;26(16):2728-2738

14.Min Liu, Jian Zhang, Xi Zhu, Wei Shan, Lian Li, Jiaju Zhong, Zhirong Zhang and YuanHuang*. Efficient mucus permeation and tight junction opening by dissociable "mucus-inert" agents coated trimethyl chitosan nanoparticles for oral insulin delivery. J. Control. Release. 2016;222:66-77

15.Lian Li, Wei Sun, Jiaju Zhong, Qingqing Yang, Xi Zhu, Zhou Zhou, Zhirong Zhang, and Yuan Huang*. Multistage Nanovehicle Delivery System based on Stepwise Size Reduction and Charge Reversal for Programmed Nuclear Targeting of Systemically Administered Anticancer Drugs. Adv. Funct. Mater. 2015;25:4101-4113

16.Wei Shan, Xi Zhu, Min Liu, Lian Li, Jiaju Zhong, Wei Sun, Zhirong Zhang, and Yuan Huang*. Overcoming the Diffusion Barrier of Mucus and Absorption Barrier of Epithelium by Self-Assembled Nanoparticles for Oral Delivery of Insulin. ACS nano. 2015 24;9(3):2345-56

专利

1、  一种岩白菜素、盐酸西替利嗪的复方口服剂型。授权号：ZL2010 1 0127015.6（第1发明人）。

2、  一种用于负载水溶性小分子药物的多核芯粘附微球及其制备方法。授权号：ZL2010 1 0271029.5（第1发明人）。

3、  一种载蛋白类药物的固体脂质纳米粒给药系统。授权号：ZL 201110041868.2（第1发明人）。

4、  一种基于N-(2-羟丙基)甲基丙烯酰胺聚合物的纳米粒及其制备方法。授权号：ZL 201510057676.9（第1发明人）。