李曼 副教授 （博士生导师）
单位：四川大学华西药学院药剂学系
通讯地址：四川省成都市人民南路三段十七号四川大学华西药学院药学大楼609-1室
E-mail: manli@scu.edu.cn
简历
2006.09-2010.06 四川大学生命科学学院 生物技术基地班 理学学士
2010.09-2013.06 四川大学华西药学院 药剂学 理学硕士 导师：张志荣 教授
2013.09-2016.06 四川大学华西药学院 药剂学 理学博士 导师：张志荣 教授
2016.07-2020.09 四川大学华西药学院药剂学系 专职博士后/助理研究员、副研究员（专职科研），导师：何勤 教授
2020.09-至今 四川大学华西药学院药剂学系 副教授
2021.07-至今 四川大学华西药学院药剂学系 博士生导师
2023.02-2024.01 英国帝国理工访问研究员，合作导师：Professor Dame Molly Stevens FREng FRS
研究方向
新型药物递释系统及其机制研究
学术兼职
中国颗粒学会第四届青年理事
中国颗粒大会药物制剂与粒子设计专业委员会委员
中国抗癌协会肿瘤标志专业委员会青委会委员
European Journal of Pharmaceutics and Biopharmaceutics 编委
Asian Journal of Pharmaceutical Sciences青年编委
科研项目
1. 自然科学基金面上项目，82173771，2022.01-2025.12，55万，主持
2. 自然科学基金青年项目，81703450，2018.01-2020.12，20.1万，主持
3. 四川省自然科学基金面上项目，2025ZNSFSC0682，2025.1-2026.12，20万，主持
4. 四川省自然科学基金青年科学基金项目，2022NSFSC1523，2022.1-2023.12，10万，主持
5. 四川省科技厅“苗子工程”项目，2019JDRC0097，2019.01-2021.01，10万，主持
6. 四川大学博士后交叉学科创新启动基金项目，2019-2021，20万，主持
7. 中国博士后科学基金特别资助，2018T110985，2018-2020，15万，主持
8. 中国博士后科学基金面上资助（一等），2017M620429，2017-2019，8万，主持
9. 四川大学专职博士后研发基金，2018.01-2019.12，15万，主持
10. 自然科学基金重大项目，81690261，332.6万元，2017.1-2021.12，参研
11. 自然科学基金国际合作（交流）项目，NSFC-STINT(中瑞)，82311530116，2023.05-2026.04，40万元，参研
获得奖励
1. 第七届中国国际互联网+创新创业大赛国际赛道铜奖指导教师
2. 第七届中国国际互联网+创新创业大赛省级银奖指导教师
3. 第七届“创客中国·创业天府”四川省中小企业创新创业大赛全省总决赛创客组二等奖指导教师
4. 第十五届大学生药苑论坛一等奖指导教师
5. 第二届川渝药学/中药学大学生实验技能及创新设计竞赛二等奖指导教师
6. 四川大学课堂教学质量优秀奖
7. 四川大学华西药学院本科优秀教学三等奖
代表性研究论文
1. Fang Chen, Zhidi He, Rong Guo, Min Li, Jiaxin Li, Yashi Wang, Xuan He, Zhipeng Tian, Xiaoli Ling, Lin Xiong, Wenjing Bai, Man Li*, Qin He*, Extracellular vesicle-hitchhiking nanoliposomes for cancer-associated fibroblast phenotypes modulation impede metastasis progression. Science Advances. 2025, 11, eadr5635. IF=12.5
2. .Min Li, Shuang Chen, Rong Guo, Yang Wang, Mingrui Yang, Yingke Liu, Qiang Zhang, Shiyu Zhu, Jiaxin Li, Fang Chen, Bo Wang, Man Li*, Qin He*. Microglia-Derived Nanovesicles Synchronize Macroautophagy and Chaperone-Mediated Autophagy for Alzheimer’s Therapy. Signal Transduction and Targeted Therapy. 2025, 10, 360. IF=52.7
3. Qihang Ding, Siqi Huang, Zihan Zhang, Donghu Yu, Man Li*, Qin He*, Ling Mei*. Integration of Photodiagnosis and Therapy Guided by Micro/Nanorobots. Advanced Materials. 2025, 37, 2420359. IF=27.4
4. Xuhui Wang, Dong Chen, Kexin Huang, Man Li, Changyou Zhan, Ziyan Dong, Tao Deng, Kebai Ren, Yue Qiu, Zhirong Zhang,* Qin He*. Albumin-Hitchhiking Drug Delivery to Tumor-Draining Lymph Nodes Precisely Boosts Tumor-Specific Immunity through Autophagy Modulation of Immune Cells. Advanced Materials. 2023, 35, 29, 2211055. IF=27.4
5. Miao Deng, Rong Guo, Yang Wang, Jia-Xin Li, Jiao He, Man Li* and Qin He*. Curbing Exosome Communications via Introducing Artificial Membrane Receptors for Metastatic Pancreatic Cancer Therapy. Advanced Materials. 2023, 35, 29, 2303736. IF=27.4
6. Yashi Wang, Sheng Yin, Dan He, Yujia Zhang, Ziyan Dong, Zhipeng Tian, Jiayu Li, Fang Chen, Yang Wang, Man Li*, Qin He*. Dual Strategies Based on Golgi Apparatus/Endoplasmic Reticulum Targeting and Anchoring for High-Efficiency siRNA Delivery and Tumor RNAi Therapy. ACS Nano, 2025, 19(3), 3791–3806. IF=16
7. Junyu Wu, Yang Long, Man Li*, Qin He*. Emerging nanomedicine-based therapeutics for hematogenous metastatic cascade inhibition: Interfering with the crosstalk between “seed and soil”. Acta Pharmaceutica Sinica B, 2021,11(8), 2286-2305. IF=14.6
8. Jiaojie Wei, Yang Long, Rong Guo, Xinlei Liu, Xian Tang, Jingdong Rao, Sheng Yin, Zhirong Zhang, Man Li*, Qin He*. Multifunctional polymeric micelle-based chemo-immunotherapy with immune checkpoint blockade for efficient treatment of orthotopic and metastatic breast cancer. Acta Pharmaceutica Sinica B, 2019; 9(4): 819–831. IF=14.6
9. Xiaoli Ling, Ziyan Dong, Jiao He, Dong Chen, Dan He, Rong Guo, Qin He*, Man Li*. Advances in Polymer-Based Self-Adjuvanted Nanovaccines. Small, 2025, 21,6, 2409021. IF=12.1
10. Lin Xiong, Shuang Chen, Sihui Li, Dan He, Yashi Wang, Qiang Zhang, Zhidi He, Man Li*, Qin He*. ATP-responsive tumor targeted lipid nanoparticle for enhanced siRNA delivery and improved treatment efficacy in melanoma. Journal of Controlled Release, 2025, 382, 113622. IF=11.5
11. Dong Chen, Xiaoli Ling, Yashi Wang, Qiang Zhang, Xuan He, Ziyan Dong, Man Li*, Qin He*. Autophagy-activating aluminum hydroxide nanovaccine for enhanced antigen presentation and anti-tumor immunity. Journal of Controlled Release, 2025, 377, 223-235. IF=11.5
12. Qihang Ding1, Haiyan Chen1, Yifan Zhang1, Junbin Yang, Man Li*, Qin He*, Ling Mei*. Innovative Integration of Nanomedicines and Phototherapy to Modulate Autophagy for Enhanced Tumor Eradication. Journal of Controlled Release, 2025, 377, 855-879. IF=11.5
13. Xiaoli Ling, Zhipeng Tian, Dong Chen, Yujia Zhang, Ziyan Dong, Dan He, Jiayu Li, Zhidi He, Jiaxin Li, Fang Chen, Qin He, Man Li*. Functionalized aluminum hydroxide-based self-adjuvanted nanovaccine orchestrates antitumor immune responses via Dectin-1 signaling. Journal of Controlled Release, 2025, 378, 559-572. IF=11.5
14. Man Li, Mengmeng Li, Yiliang Yang, Yingke Liu, Hanbing Xie, Qianwen Yu, Lifeng Tian, Xian Tang, Kebai Ren, Jianping Li, Zhirong Zhang, Qin He*. Remodeling tumor immune microenvironment via targeted blockade of PI3K-γ and CSF-1/CSF-1R pathways in tumor associated macrophages for pancreatic cancer therapy. Journal of Controlled Release, 2020, 321, 23-35. IF=11.5
15. Man Li, Hanbing Xie, Yingke Liu, Chunyu Xia, Xingli Cun, Yang Long, Xiaoxiao Chen, Miao Deng, Rong Guo, Zhirong Zhang, Qin He*. Knockdown of hypoxia-inducible factor-1 alpha by tumor targeted delivery of CRISPR/Cas9 system suppressed the metastasis of pancreatic cancer. Journal of Controlled Release, 2019, 304, 204-215. IF=11.5
16. Chunyu Xia, Wenjing Bai, Tao Deng, Ting Li, Ling Zhang, Zhengze Lu, Zhirong Zhang, Man Li*, Qin He*. Sponge-like nano-system suppresses tumor recurrence and metastasis by restraining myeloid-derived suppressor cells-mediated immunosuppression and formation of pre-metastatic niche. Acta Biomaterialia, 2023, 158,708–724. IF=9.7
17. Shuya Zang, Kexin Huang, Jiaxin Li, Kebai Ren, Ting Li, Xuan He, Yuan Tao, Jiao He, Ziyan Dong, Man Li*, Qin He*. Metabolic Reprogramming by Dual-targeting Biomimetic Nanoparticles for Enhanced Tumor Chemo-Immunotherapy. Acta Biomaterialia, 2022, 148, 181-193. IF=9.6
18. Kebai Ren, Jiao He, Yue Qiu, Zhuping Xu, Xuhui Wang, Jiaxin Li, Shuya Zang, Yiliang Yang, Jiaxin Li, Yang Long, Zhirong Zhang, Man Li*, Qin He*. A neutrophil-mediated carrier regulates tumor stemness by inhibiting autophagy to prevent postoperative triple-negative breast cancer recurrence and metastasis. Acta Biomaterialia, 2022, 145: 185-199. IF=9.6
19. Rong Guo, Miao Deng, Jiaxin Li, Xuan He, Penghui He, Houqin Liu, Yunxia Ye, Ziyi Mo, Xuan He, Man Li* and Qin He*. Depriving Tumor Cells of Ways to Metastasize: Ferroptosis Nanotherapy Blocks Both Hematogenous Metastasis and Lymphatic Metastasis. Nano Lett. 2023, 23, 3401−3411. IF=9.1
20. Jiayu Li, Sihui Li, Dan He, Yeyi Hu, Zhipeng Tian, Yashi Wang, Xiaoli Ling, Zhidi He, Man Li*, Qin He*. Rb1-Based Dual-Functional Liposomes for Enhanced siRNA Delivery and Synergistic Anti-Fibrotic Therapy of Hepatic Fibrosis. Nano Research, 2025, 18(11): 94908113. IF=9
