陈治超，副研究员，硕士生导师
联系方式
单位：四川大学华西药学院药物化学系
地址：成都市人民南路三段华西药学院
E-mail：chenzhichao@scu.edu.cn
教育及工作经历
2022.10--至今，四川大学华西药学院药物化学系，副研究员，硕士生导师
2019.01—2022.10，四川大学华西药学院药物化学系，专职博士后
2015.09--2019.01，四川大学华西药学院药物化学系，理学博士，导师：陈应春
2010.09--2013.06，沈阳药科大学药物化学系，理学硕士，导师：宫平教授
教授
2006.09--2010.06，沈阳药科大学中药学系，理学学士
研究方向：
聚焦于新型有机合成方法学的发展和手性药物及关键中间体的高效合成工艺开发。现主要围绕有机小分子/金属配合物协同催化、自动串联催化反应等开展基础研究；并应用新的不对称催化策略和技术发展新的合成工艺，实现手性原料药物的高效制备。
主要科研项目：
1. 国家自然科学基金青年项目：Lewis碱/金属配合物协同催化不对称环化反应研究，项目号：21901169，2020.01-2022.12，负责人；
2. 中国博士后科学基金面上资助：Lewis碱/金属配合物协同催化的多样性不对称反应研究，项目号：2019M663488，2020.01-2022.12，负责人；
3. 西南特色中药资源国家重点实验室开放基金：吖丙（丁）啶衍生物分子内去对称化反应构建复杂手性氮杂环化合物研究，项目号：SKLTCM2022018，2022.09-2024.09，负责人；
4. 四川大学专职博士后科研基金：金属配合物/Lewis碱协同催化构建复杂螺环化合物的研究，项目号：2020SCU12019，2020.01-2021.12，负责人；
近年代表性论文：
1) Yuan Hu, Jin-Yu Huang, Ru-Jie Yan, Zhi-Chao Chen,* Qin Ouyang, Wei Du Ying-Chun Chen*, Diastereodivergent cis- and trans-fused [4 + 2] annulations of cyclic 1,3-dienes and 1-azadienes via ligand-controlled palladium catalysis, Chem. Sci., 2023, 14, 1896−1901.
2) Guo-Li Shen, Yuan-Yuan Tan, Yuan Hu, Zhi-Chao Chen,* Wei Du, Ying-Chun Chen*, Asymmetric Construction of Multifunctional γ-Lactams from 1,3-Dienes and α-Ketoamides via Pd(0)-π-Lewis Base Catalysis, Org. Lett. 2023, 25, 6649–6653.
3) Bo Zhu, Teng Sun, Zhi-Chao Chen,* Lu Gao, Wei Du and Ying-Chun Chen*, Substrate-controlled divergent synthesis with ortho-vinyl-functionalised 1,3-enynes and imines via palladium catalysis, Org. Chem. Front., 2023, 10, 3300−3306.
4) Jian-Xiang Zhu, Fu Pi, Teng Sun, Wen-Yu Huang, Lu Gao, Zhi-Chao Chen,* Wei Du, Ying-Chun Chen*, Asymmetric 2,4-Dienylation/[4 + 2] Annulation Cascade to Construct Fused Frameworks via Auto-Tandem Palladium Catalysis, Org. Lett. 2023, 25, 3682−3686
5) Jian-Bin Lu, Shu-Yuan Liang, Wu-Tao Gui, Zhi-Chao Chen,* Wei Du, Ying-Chun Chen*, Asymmetric Assemblies of 1,3-Dienes, Sulfuric Diamide, and Aldehydes to Access 1,3-Diamines through Relay Amine/Palladium Catalysis. Org. Lett. 2023, 25, 576−580.
6) Jin-Yu Huang, Yuan Hu, Zhi-Chao Chen,* Gu Zhan,* Wei Du, Ying-Chun Chen*, Rapid Construction of Hexahydro-1H-pyrrolo[3,2-c]pyridines with Functionalized 1,3-Enynes and Imines via Palladium Catalysis. Asian J. Org. Chem. 2023, e202300225
7) Jian-Xiang Zhu, Zhi-Chao Chen,* Wei Du, and Ying-Chun Chen*, Asymmetric Auto-Tandem Palladium Catalysis for 2,4-Dienyl Carbonates: Ligand-Controlled Divergent Synthesis, Angew. Chem. Int. Ed. 2022, 61, e202200880.
8) Zhi Chen, Yu-Fan Li, Shun-Zhong Tan, Qin Ouyang, Zhi-Chao Chen,* Wei Du, Ying-Chun Chen*, Chem. Sci. 2022, 13, 12433–12439.
9) Ze-Liang He, Peng Chen, Zhi-Chao Chen,* Wei Du, and Ying-Chun Chen*, Construction of Hydrodibenzo[b,d]furan Frameworks from Morita−Baylis−Hillman Carbonates of Isatins and o‑Hydroxy Enones via Palladium and Brønsted Base Relay Catalysis, Org. Lett. 2022, 24, 100−104.
10) Jie Zhang, Xue Song, Zhi-Chao Chen,* Wei Du, Ying-Chun Chen* New J. Chem. 2022, 46, 16382–163386.
11) Yue Li, Peng Chen, Zhi-Chao Chen,* Wei Du, Ying-Chun Chen*, Cooperative Tertiary Phosphine/Palladium Catalyzed Nucleophilic Allylation between Morita−Baylis−Hillman Carbonates and Alkenes, Eur. J. Org. Chem. 2022, 2022, e202200218.
12) Zhi Chen, Zhi-Chao Chen,* Wei Du, Ying-Chun Chen*, Asymmetric [4+3] Annulations for Constructing Divergent Oxepane Frameworks via Cooperative Tertiary Amine/Transition Metal Catalysis, Org. Lett. 2021, 23, 8559−8564.
13) Jian-Bin Lu, Chong-Hui Shi, Di Hu, Xin-Yue Gao, Zhi-Chao Chen,* Wei Du, Ying-Chun Chen*, Regioselectivity Umpolung in Asymmetric Diels−Alder Reaction of ortho-Formyl-Substituted Cinnamates and Dienals via Double Aminocatalysis, Org. Lett. 2021, 23, 145−149.
14) Yue Li, Peng Chen, Zhi-Chao Chen,* Wei Du, Qin Ouyang, Ying-Chun Chen*, Palladium-catalysed oxidative nucleophilic allylation between alkenes and activated ketimines, Org. Chem. Front. 2021, 8, 5418−5423.
15) Zhi-Chao Chen, Wei Du, Ying-Chun Chen*, New Amines and Activation Modes in Asymmetric Aminocatalysis, Chin. J. Chem. 2021, 39, 1775–1786.
16) Peng Chen, Yue Li, Zhi-Chao Chen,* Wei Du, and Ying-Chun Chen*, Pseudo-Stereodivergent Synthesis of Enantioenriched Tetrasubstituted Alkenes by Cascade 1,3-Oxo-Allylation/Cope Rearrangement, Angew. Chem. Int. Ed. 2020, 59, 7083–7088.
17) Cui-Xia Hu, Lin Chen, Di Hu, Xue Song, Zhi-Chao Chen,* Wei Du, Ying-Chun Chen*, Construction of Enantioenriched 9H‑Fluorene Frameworks via a Cascade Reaction Involving Remote Vinylogous Dynamic Kinetic Resolution, Org. Lett. 2020, 22, 8973−8977.
18) Zhi-Chao Chen, Zhi Chen, Wei Du,* Ying-Chun Chen*, Transformations of Modified Morita−Baylis−Hillman Adducts from Isatins Catalyzed by Lewis Bases, Chem. Rec. 2020, 20, 541–555.
19) Zhi-Chao Chen, Zhi Chen, Zhen-Hong Yang, Li Guo, Wei Du,* Ying-Chun Chen*, Cooperative Tertiary Amine/Chiral Iridium Complex Catalyzed Asymmetric [4+3] and [3+3] Annulation Reactions, Angew. Chem. Int. Ed. 2019, 58, 15021−15025.
20) Zhi-Chao Chen, Peng Chen, Zhi Chen, Qin Ouyang, Hua-Ping Liang,* Ying-Chun Chen*, Organocatalytic Enantioselective 1,3-Difunctionalizations of Morita−Baylis− Hillman Carbonates, Org. Lett. 2018, 20, 6279−6283.
