药物化学系

王慧婧 副教授(硕士生导师)

来源: 发布时间:2024年09月02日 点击数:

单位:四川大学华西药学院 药物化学系

通讯地址:成都市人民南路三段17号四川大学华西药学院610041

E-mail: hjwang0313@scu.edu.cn, hjwang0313@163.com


教育与工作经历:

2008.09-2012.06 四川大学华西药学院 理学学士

2012.09-2017.06 重庆大学创新药物研究中心 工学博士(导师:秦勇教授)

2017.09-2019.12 美国加州大学圣地亚哥分校(UCSD)博士后(导师:Dionicio Siegel教授)

2020.04-2023.08 四川大学华西药学院药物化学系,特聘副研究员

2023.09-至今 四川大学华西药学院药物化学系,副教授


研究方向:

1. 手性药物的不对称合成

2. 生物酶的理性设计及其在药物合成中的应用


科研项目

1. 国家自然科学基金青年科学基金,天然核苷及类似物的立体发散性合成研究,项目号:222011922023-2025,负责人;

2. 四川省自然科学基金面上项目,单加氧酶的理性设计助力长春胺类生物碱的精准合成,项目号:2022NSFSC06152022-2023,负责人;

3. 2020-2023 四川大学引进人才科研启动经费资助项目,负责人。


曾获奖项

12022年入选四川省青年“千人计划”(天府峨眉计划)

22021年课堂教学质量优秀奖

32022年四川大学华西药学院红叶实验奖教金优秀实验课程组

42023年华西药学院本科优秀教学三等奖

52023年四川大学重大基础研究成果奖(二类)


班主任工作

担任2018级药学32022级药学3班的班主任


“大学生创新创业训练计划”项目指导

12022年度“大学生创新创业训练计划”项目(校级),呋喃环类核苷类药物合成中关键中间体的合成研究,20221328L

22024年度“大学生创新创业训练计划”项目(省级),异头碳为季碳的核苷及类似物的合成中关键中间体的研究,S202410610562


发表论文

1. Xiangtao Chen, Huijing Wang, Jie Zeng, Qiuhong Li, Tonghui Zhang, Qiaoyun Yang, Pei Tang*, Fen-Er Chen*. Stereodivergent Total Synthesis of Tacaman Alkaloids. Angew. Chem. Int. Ed. 2024, 63, e202407149 (一区,IF 16.1).

2. Qi Wang, Jiayi Mu, Jie Zeng, Linxi Wan, Yangyang Zhong, Qiuhong Li, Yitong Li, Huijing Wang*, and Fener Chen*. Additive-controlled asymmetric iodocyclization enables enantioselective access to both a- and b-nucleosides. Nat. Common. 2023, 14, 138. (一区,IF 17.694)

3. Jia-Qi Wang, Xu Ling, Hui-Jing Wang*, and Fen-Er Chen*. a-Lipoic acid chemistry: the past 70 years. RSC Adv., 2023, 13, 36346–36363 (三区,IF 3.9).

4. Hui-Jing Wang, Yang-Yang Zhong, You-Cai Xiao* and Fen-Er Chen*. Chemical and chemoenzymatic stereoselective synthesis of β-nucleosides and their analogues. Org. Chem. Front. 2022, 9, 1719−1741. (一区,IF 5.281);

5. Junxia Wei, Huijing Wang (co-first author), Qinwen Zheng, Jifa Zhang, Zhichao Chen, Jiaxing Wang, Liang Ouyang, Yuxi Wang*.Recent research and development of inhibitors targeting sentrin-specific protease 1 for the treatment of cancers. Eur. J. Med. Chem. 2022, 241, 114650. (一区,IF 7.088)

6. Hongmin Qu, Yu Chen, Xiangling Ceng, Pei Tang, Huijing Wang* and Fen-Er Chen*. Enantioselective synthesis of chiral 3-alkynyl-3-hydroxyindolin-2-ones by Zn/bis(sulfonamide)-diamine catalyzed asymmetric addition of alkynes to isatins. Asian J. Org. Chem. 2022, 11, e202200188 (1 of 5). (三区,IF 3.116)

7. Huijing Wang, Qiuyan Dong, Qinxia Xie, Pei Tang*. Asymmetric synthesis of ABC tricyclic systems in Daphniphyllum alkaloid. Chin. Chem. Lett. 2020, 31, 685-688. (一区,IF 8.455)

8. Huijing Wang, Matthew J. Kolar, Tina Chang, José Rizo, Srihari Konduri, Clare McNerlin, Alan Saghatelian, and Dionicio Siegel*. Stereochemistry of Linoleic Acid Esters of Hydroxy Linoleic Acids. Org. Lett. 2019, 21, 8080−8084. (一区,IF 6.072)

9. Yan-zhao Liu, Yao Hu, Guang-hui Lv, Rui-fang Nie, Yao Peng, Chen Zhang, Song-yang Lv, Li Hai, Hui-jing Wang*, and Yong Wu*. Synthesis of 1,2-Benzothiazines via C−H Activation/Cyclization in a Recyclable, Mild System. ACS Sustainable Chem. Eng. 2019, 7, 13425−13429. (一区,IF 8.198)

10. Yi Luo, Lingmei Guo, Xinling Yu, Haosheng Ding, Huijing Wang*, and Yong Wu*. Cp*IrIII-Catalyzed [3+2] Annulations of N-Aryl-2- aminopyrimidines with Sulfoxonium Ylides to Access 2-Alkyl Indoles Through C–H Bond Activation. Eur. J. Org. Chem. 2019, 3203–3207. (三区,IF 3.261)

11. Huijing Wang, Tina Chang, Srihari Konduri, Jianbo Huang, Alan Saghatelian, Dionicio Siegel. Synthesis of chemically edited derivatives of the endogenous regulator of inflammation 9-PAHSA. J. Antibiot. 2019, 72 (6), 498-506. (四区,IF 2.23)

12. Huijing Wang, Pei Tang, Qilong Zhou, Dan Zhang*, Zhitao Chen, Hongxiu Huang, Yong Qin*. One-Pot Synthesis of Multisubstituted Butyrolactonimidates: Total Synthesis of (-)-Nephrosteranic Acid, J. Org. Chem. 2015, 80, 2494-2505. (二区,IF 4.198);

13. Hongxiu Huang, Huijing Wang (co-first author), Ling Tan, Shuqing Wang, Pei Tang, Hao Song*, Xiao-Yu Liu, Dan Zhang, Yong Qin*. Asymmetric Michael Addition Induced by (R)-tert-Butanesulfinamide and Synthesis of Chiral Pyrazolidinone Derivatives, J. Org. Chem. 2016, 81, 10506-10516. (二区,IF 4.198)

  编辑:四川大学华西药学院