李炼 副研究员 （硕士生导师）
单位：四川大学华西药学院药剂学系
通讯地址：成都市人民南路三段17号四川大学华西药学院药学大楼716室
E-mail: liliantripple@163.com
简历
2008-2012 四川大学华西药学院，获理学学士学位
2012-2016 四川大学华西药学院，获药剂学博士学位
2016-2020 美国犹他大学药学院，博士后（师从Jindrich Koepecek院士）
2021-至今 四川大学华西药学院，特聘副研究员
2022-至今 四川大学华西药学院药剂学系，硕士生导师
研究方向
靶向药物递释系统的构建及机制研究
科研项目
1. 国家自然科学基金青年项目，2022-2024，30万，主持
2. 四川省科技厅青年项目，2022-2023，10万，主持
3. 四川省2021年度“天府峨眉计划”青年人才项目，50万，主持
4. 四川大学引进人才科研启动经费资助项目，2021-2023，30万，主持
近五年代表性研究论文
1. Junlin Li, Ping Zhang, Minglu Zhou, Chendong Liu, Yuan Huang*, Lian Li*. Trauma-Responsive Scaffold Synchronizing Oncolysis Immunization and Inflammation Alleviation for Postoperative Suppression of Cancer Metastasis. ACS Nano, 2022, 16: 6064–6079. (IF=18.02)
2. Minglu Zhou, Qingting Zuo, Yuan Huang, Lian Li*. Immunogenic Hydrogel Toolkit Disturbing Residual Tumor “Seeds” and Pre-metastatic “Soil” for Inhibition of Postoperative Tumor Recurrence and Metastasis. Acta Pharmaceutica Sinica B, 2022, 12: 2029-2042. (IF=14.90)
3. Liqiang Chen, Chendong Liu, Yucheng Xiang, JiayanLyu, Zhou Zhou, Tao Gong, Huile Gao, Lian Li*, Yuan Huang*. Exocytosis Blockade of Endoplasmic Reticulum-Targeted Nanoparticle Enhances Immunotherapy. Nano Today, 2021: 42, 101356. (IF=18.96)
4. Yucheng Xiang, Liqiang Chen, Chendong Liu, Xiaoli Yi, Lian Li*, Yuan Huang*. Redirecting Chemotherapeutics to Endoplasmic Reticulum Increases Tumor Immunogenicity and Potentiates Anti-PD-L1 Therapy. Small, 2022, 18: 2104591. (IF=15.15)
5. Minglu Zhou, Chaohui Luo, Zhou Zhou, Lian Li*, Yuan Huang*. Improving Anti-PD-L1 Therapy in Triple Negative Breast Cancer by Polymer-Enhanced Immunogenic Cell Death and CXCR4 Blockade. Journal of Controlled Release, 2021, 334: 248-262. (IF=11.47)
6. Lian Li, Jiawei Wang, D. Christopher Radford, Jindrich Kopecek, Jiyuan Yang*. Combination Treatment with Immunogenic and Anti-PD-L1 Polymer-Drug Conjugates of Advanced tumors in a Transgenic MMTV-PyMT Mouse Model of Breast Cancer, Journal of Controlled Release, 2021, 332: 652-659. (IF=11.47)
7. Lian Li, Yachao Li, Chieh‐Hsiang Yang, D. Christopher Radford, Jiawei Wang, Margit Janát‐Amsbury, Jindřich Kopeček*, Jiyuan Yang*, Inhibition of Immunosuppressive Tumors by Polymer-Assisted Inductions of Immunogenic Cell Death and Multivalent PD‐L1 Crosslinking, Advanced Functional Materials, 2020, 30: 1908961. (IF=19.92)
8. Lian Li, Jiawei Wang, Yachao Li, D. Christopher Radford, Jiyuan Yang*, Jindřich Kopeček*, Broadening and Enhancing Functions of Antibodies by Self-Assembling Multimerization at Cell Surface, ACS Nano, 2019, 13: 11422-11432. (IF=18.02)
9. Lian Li, Jiyuan Yang, Sirima Soodvilai, Jiawei Wang, Praneet Opanasopit, Jindřich Kopeček*, Drug-Free Albumin-Triggered Sensitization of Cancer Cells to Anticancer Drugs, Journal of Controlled Release, 2019, 293: 84-93. (IF=11.47)
10. Lian Li, Jiyuan Yang, Jiawei Wang, Jindřich Kopeček*, Amplification of CD20 Cross-Linking in Rituximab-Resistant B-Lymphoma Cells Enhances Apoptosis Induction by Drug-Free Macromolecular Therapeutics, ACS Nano, 2018, 12: 3658-3670. (IF=18.02)
授权专利
1. 中国专利：一种可同时放大免疫原性细胞死亡以及增强抗肿瘤效果的联合用药物；黄园；向宇成；李炼；ZL201910896703.X。
2. 美国专利：Polymeric Drug Delivery Conjugates and Methods of Making and Using Thereof, Jiyuan Yang, Lian Li, C. Matthew Peterson, Jindrich Kopecek, U.S. Patent Application No. 17/754,915.
