杜广盛 副研究员
单位：四川大学华西药学院药剂系
通讯地址：成都市人民南路三段17号四川大学华西药学院
Email: gshengdu@scu.edu.cn
教育和工作经历：
2006-2010 山东大学药学院，理学学士
2010-2013 天津大学化工学院，工学硕士
2013-2018 荷兰莱顿大学药学院，药剂学博士
2018-2022 四川大学华西药学院，博士后、副研究员（专职科研），合作导师: 孙逊教授
2022-至今 四川大学华西药学院药剂系，副研究员
研究方向:
1. 微针药物递送系统的研究
2. 新型疫苗和佐剂递送系统的研究
科研项目：
1. 国家自然科学基金专项项目，2023 - 2025，主持
2. 国家自然科学基金青年基金，2021 - 2023，主持
3. 四川省自然科学基金青年基金，2022 - 2023，主持
4. 教育部博士后基金面上项目，2020 - 2021，主持
获奖：
1. 2023年第十八届“挑战杯”全国大学生课外学术科技作品竞赛一等奖指导教师
2. 2023年第十七届“挑战杯”四川省大学生课外学术科技作品竞赛特等奖指导教师
3. 2022年四川大学华西药学院“红叶实验奖学奖教金”
代表性研究论文：
1. Xuanyu Wang#, Xiaofang Zhong#, Zhiqiang Xie, Yuanhao Zhao, Hairui Wang, Zhirong Zhang, Tao Gong, Guangsheng Du*, Xun Sun*. A trinity strategy: Mesoporous platinum nanoparticles serve as a photoenhanced nanoplatform for tumor immunotherapy. Chemical Engineering Journal, 2024, 495:153365.
2. Jiaxuan Zhao, Penghui He, Min Jiang, Chunting He, Yuanhao Zhao, Zhihua Zhang, Zhibing Zhang, Guangsheng Du*, Xun Sun*. Transdermally delivered tolerogenic nanoparticles induced effective immune tolerance for asthma treatment. Journal of Controlled Release, 2024, 366:637-649.
3. Yuanhao Zhao, Xiaoyan Chen, Penghui He, Xuanyu Wang, Yanhua Xu, Rui Hu, Yangsen Ou, Zhihua Zhang, Zhibing Zhang, Guangsheng Du*, Xun Sun*. Transdermal microneedles alleviated rheumatoid arthritis by inducing immune tolerance via skin-resident antigen presenting cells. Small, 2023:2307366.
4. Guangsheng Du, Ming Qin, Xun Sun*. Recent progress in application of nanovaccines for enhancing mucosal immune responses. Acta Pharmaceutica Sinica B, 2023, 13:2334-2345.
5. Zhengjun Chen, Xinyan Hao, Hairui Wang, Xiaofang Zhong, Xiaoyan Chen, Yuanhao Zhao, Yuandong Zhang, Guangsheng Du*, Xun Sun*. Smart combination of aluminum hydroxide and MF59 to induce strong cellular immune responses. Journal of Controlled Release, 2022, 349:699-711.
6. Guangsheng Du, Penghui He, Jiaxuan Zhao, Chunting He, Min Jiang, Zhihua Zhang, Zhibing Zhang, Xun Sun*. Polymeric microneedle-mediated transdermal delivery of melittin for rheumatoid arthritis treatment. Journal of Controlled Release, 2021, 336:537-548.
7. Ming Qin, Guangsheng Du*, Xun Sun*. Recent advances in the noninvasive delivery of mRNA. Accounts of Chemical Research, 2021, 54:4262-4271.
8. Guangsheng Du, Zhihua Zhang, Penghui He, Zhibing Zhang*, Xun Sun*. Determination of the mechanical properties of polymeric microneedles by micromanipulation. Journal of the Mechanical Behavior of Biomedical Materials, 2021, 117:104384.
9. Xiaoyu Hong, Xiaofang Zhong, Guangsheng Du, Yingying Hou, Yunting Zhang, Zhirong Zhang, Tao Gong, Ling Zhang*, Xun Sun*. The pore size of mesoporous silica nanoparticles regulates their antigen delivery efficiency. Science Advances, 2020, 6:eaaz4462.
10. Guangsheng Du, Xun Sun*. Engineering nanoparticulate vaccines for enhancing antigen cross-presentation. Current Opinion in Biotechnology, 2020, 66:113-122.
11. Guangsheng Du, Rania M. Hathout, Maha Nasr, M. Reza Nejadnik, Jing Tu, Roman I. Koning, Abraham J. Koster, Bram Slütter, Alexander Kros, Wim Jiskoot, Joke A. Bouwstra*, Juha Mönkäre. Intradermal vaccination with hollow microneedles: A comparative study of various protein antigen and adjuvant encapsulated nanoparticles. Journal of Controlled Release, 2017, 255:109-118.
12. Anne Marit de Groot#, Guangsheng Du#, Juha Mönkäre, Anouk C.M. Platteel, Femke Broere, Joke A. Bouwstra, Alice J.A.M. Sijts*. Hollow microneedle-mediated intradermal delivery of model vaccine antigen-loaded PLGA nanoparticles elicits protective T cell-mediated immunity to an intracellular bacterium. Journal of Controlled Release, 2017, 266:27-35.
