王蛘 特聘研究员 (博士生导师)
单位：四川大学华西药学院 药剂学系
通信地址：四川省成都市人民南路三段17号四川大学华西药学院，邮编：610041
Email：yang_wang@scu.edu.cn
Lab web: http://yangwalab.com
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个人简介及经历
王蛘，博士, 四川大学华西药学院药剂学系特聘研究员、研究组长、博士生导师。2023年2月于瑞典卡罗林斯卡医学院（Karolinska Institutet）医学生物化学与生物物理系（Department of Medical Biochemistry and Biophysics）获得医学科学博士学位（导师：Björn Högberg 教授），研究方向为DNA折纸结构设计及其在药剂学中的纳米药物应用。随后于美国哈佛大学医学院/丹娜法伯癌症研究所从事博士后研究（合作导师：Ming-Ru Wu 教授），致力于人工智能驱动的合成生物学策略在免疫治疗中的应用。2025年6月入职四川大学华西药学院。
入选2024年国家海外高层次人才引进计划（青年项目）。以第一作者或共同第一作者在 Nature Nanotechnology、Nature Communications、Advanced Materials、ACS Nano 等国际权威期刊发表论文33篇，申请国家发明专利2项。代表性研究成果获国内外同行高度评价，并被 Nature Nanotechnology 等学术期刊及专业媒体作为研究亮点专题报道。
研究方向
1, 核酸折纸结构的设计与功能化，及其在药剂学中的纳米药物应用 (Design and functionalization of nucleic acid origami structures for nanomedicine applications in biopharmaceutics);
2, 基于人工智能的合成生物学策略在免疫治疗中的应用探索 (AI-driven synthetic biology strategies for immunotherapy);
3, 合成细胞的构建与调控，及其在生物药剂学中的创新转化应用 (Construction and regulation of synthetic cells for innovative translational applications in biopharmaceutics)。
科研项目
1，国家自然科学基金优秀青年科学基金项目（海外） 2025−2027，主持
2，四川大学引进人才科研启动经费资助项目 2025−2028，主持
3，瑞典研究理事会（Swedish Research Council）资助项目2025
3−2026， 主持
获奖
1，2020年四川省科技进步二等奖（自然科学类）（第3完成人）
2，第七届中国国际“互联网+”大学生创新创业大赛全国总决赛国际赛道金奖
3，第五届中国“互联网+”大学生创新创业大赛全国总决赛国际赛道国家银奖
大会特邀报告
1, 2025年6月，中国化学会第十二届DNA纳米技术研讨会，学术报告 (中国, 成都)
2, 2024年4月，第21届纳米科学基础年度会议（FNANO 2024），学术报告 (美国, 犹他, snowbird)
3, 2023年4月，第20届纳米科学基础年度会议（FNANO 2024），学术报告 (美国, 犹他, snowbird)
学术兼职
1, European Journal of Pharmaceutics and Biopharmaceutics，编委
2, 担任审稿人为Nature Communications, Journal of the American
Chemical Society, ACS Central Science，European Journal of Pharmaceutics
and Biopharmaceutics等杂志进行同行评审
近五年代表性论文:
(1) Yang Wang, Igor Baars, Ieva Berzina, Iris Rocamonde-Lago, Boxuan Shen, Yunshi Yang, Marco Lolaico, Janine Waldvogel, Ioanna Smyrlaki, Björn Högberg*. A DNA robotic switch with regulated autonomous display of cytotoxic ligand nanopatterns. Nature Nanotechnology. 19, pages 1366–1374 (2024)
(2) Ioanna Smyrlaki, Ferenc Fördős, Iris Rocamonde-Lago, Yang Wang, Boxuan Shen, Antonio Lentini, Vincent C Luca, Ana I Teixeira, Björn Högberg*. Soluble and multivalent Jag1 DNA origami nanopatterns activate Notch without pulling force. Nature Communications. 15, Article number: 465 (2024).
(3) Marco Lolaico, Sebbe Blokhuizen, Boxuan Shen, Yang Wang, Björn Högberg*. Computer-Aided Design of A-Trail Routed Wireframe DNA Nanostructures with Square Lattice Edges. ACS Nano. 17, 7, 6565–6574 (2023).
(4) Jiaye Liu#, Yang Wang #, Chunyang Mu#, Meng Li, Kewei Li, Shan Li, Wenshuang Wu, Lingyao Du, Xiaoyun Zhang, Chuan Li, Wei Peng, Xiaofeng Zheng*, Tianfu Wen*, Zhihui Li*, Yong Liu*. Pancreatic tumor eradication via selective Pin1 inhibition in cancer-associated fibroblasts and T lymphocytes engagement. Nature Communications. 13, Article number: 4308 (2022).
(5) Yang Wang, Erik Benson, Ferenc Fördős, Marco Lolaico, Igor Baars, Trixy Fang, Björn Högberg*. DNA Origami Penetration in Cell Spheroid Tissue Models is Enhanced by Wireframe Design. Advanced Materials. 33, 2008457 (2021).
(6) Yang Wang, Igor Baars, Ferenc Fördős, Björn Högberg*. Clustering of Death Receptor for Apoptosis Using Nanoscale Patterns of Peptides. ACS Nano. 15, 6, 9614–9626 (2021).
(7) Toon Verheyen, Trixy Fang, Dominik Lindenhofer, Yang Wang, Karen Akopyan, Arne Lindqvist, Björn Högberg, Ana I Teixeira*. Spatial organization-dependent EphA2 transcriptional responses revealed by ligand nanocalipers. Nucleic Acid Research. 48, 5777–5787 (2020).
English version is as following:
Research Professor. Dr. Yang Wang
Key Laboratory of Drug-Targeting and Drug Delivery System, Ministry of Education
Department of Pharmaceutics, West China School of Pharmacy
Sichuan University, Chengdu 610041, China
Email: yang_wang@scu.edu.cn, wangyangkiscu@gmail.com
Prof. Yang Wang received his doctoral degree in early 2023 from the Department of Medical Biochemistry and Biophysics at Karolinska Institutet, Sweden (supervised by Professor Björn Högberg). His Ph.D. research focused on the design of DNA origami nanostructures and their applications in biopharmaceutics as nanomedicine platforms. He subsequently conducted postdoctoral research at Harvard Medical School and Dana-Farber Cancer Institute (supervised by Professor Ming-Ru Wu), where he worked on artificial intelligence–driven synthetic biology strategies for cancer immunotherapy. In June 2025, he joined the West China School of Pharmacy, Sichuan University, as a Research Professor (Principal Investigator and Ph.D. advisor).
Dr. Wang has published 33 research papers as first author in internationally renowned journals including Nature Nanotechnology, Nature Communications, Advanced Materials, and ACS Nano, and holds 2 patent applications. His representative research has been highly recognized by experts in the field and featured as a research highlight by journals and professional media such as Nature Nanotechnology.
Research Interests
1, Design and functionalization of nucleic acid origami structures for nanomedicine applications in biopharmaceutics; 2, AI-driven synthetic biology strategies for immunotherapy; 3, Construction and regulation of synthetic cells for innovative translational applications in biopharmaceutics
Recent selected publications:
(1) Yang Wang, Igor Baars, Ieva Berzina, Iris Rocamonde-Lago, Boxuan Shen, Yunshi Yang, Marco Lolaico, Janine Waldvogel, Ioanna Smyrlaki, Björn Högberg*. A DNA robotic switch with regulated autonomous display of cytotoxic ligand nanopatterns. Nature Nanotechnology. 19, pages 1366–1374 (2024)
(2) Ioanna Smyrlaki, Ferenc Fördős, Iris Rocamonde-Lago, Yang Wang, Boxuan Shen, Antonio Lentini, Vincent C Luca, Ana I Teixeira, Björn Högberg*. Soluble and multivalent Jag1 DNA origami nanopatterns activate Notch without pulling force. Nature Communications. 15, Article number: 465 (2024).
(3) Marco Lolaico, Sebbe Blokhuizen, Boxuan Shen, Yang Wang, Björn Högberg*. Computer-Aided Design of A-Trail Routed Wireframe DNA Nanostructures with Square Lattice Edges. ACS Nano. 17, 7, 6565–6574 (2023).
(4) Jiaye Liu#, Yang Wang #, Chunyang Mu#, Meng Li, Kewei Li, Shan Li, Wenshuang Wu, Lingyao Du, Xiaoyun Zhang, Chuan Li, Wei Peng, Xiaofeng Zheng*, Tianfu Wen*, Zhihui Li*, Yong Liu*. Pancreatic tumor eradication via selective Pin1 inhibition in cancer-associated fibroblasts and T lymphocytes engagement. Nature Communications. 13, Article number: 4308 (2022).
(5) Yang Wang, Erik Benson, Ferenc Fördős, Marco Lolaico, Igor Baars, Trixy Fang, Björn Högberg*. DNA Origami Penetration in Cell Spheroid Tissue Models is Enhanced by Wireframe Design. Advanced Materials. 33, 2008457 (2021).
(6) Yang Wang, Igor Baars, Ferenc Fördős, Björn Högberg*. Clustering of Death Receptor for Apoptosis Using Nanoscale Patterns of Peptides. ACS Nano. 15, 6, 9614–9626 (2021).
(7) Toon Verheyen, Trixy Fang, Dominik Lindenhofer, Yang Wang, Karen Akopyan, Arne Lindqvist, Björn Högberg, Ana I Teixeira*. Spatial organization-dependent EphA2 transcriptional responses revealed by ligand nanocalipers. Nucleic Acid Research. 48, 5777–5787 (2020).
