李曼 副教授 （硕士生导师）
单位：四川大学华西药学院药剂学系
通讯地址：四川省成都市人民南路三段十七号四川大学华西药学院药学大楼609-1室
E-mail: manli@scu.edu.cn
简历
2006.09-2010.06 四川大学生命科学学院 生物技术基地班 理学学士
2010.09-2013.06 四川大学华西药学院 药剂学 理学硕士 导师：张志荣 教授
2013.09-2016.06 四川大学华西药学院 药剂学 理学博士 导师：张志荣 教授
2016.07-2020.09 四川大学华西药学院药剂学系 专职博士后/助理研究员、副研究员（专职科研），合作导师：何勤 教授
2020.09-至今 四川大学华西药学院药剂学系 副教授
2021.07-至今 四川大学华西药学院药剂学系 硕士生导师
研究方向
新型药物递释系统及其机制研究
科研项目
1. 自然科学基金面上项目，82173771，2022.01-2025.12，55万，主持
2. 自然科学基金青年项目，81703450，2018.01-2020.12，20.1万，主持
3. 四川省自然科学基金青年科学基金项目，2022NSFSC1523，2022.1-2023.12，10万，主持
4. 四川省科技厅“苗子工程”项目，2019JDRC0097，2019.01-2021.01，10万，主持
5. 四川大学博士后交叉学科创新启动基金项目，2019-2021，20万，主持
6. 中国博士后科学基金特别资助，2018T110985，2018-2020，15万，主持
7. 中国博士后科学基金面上资助（一等），2017M620429，2017-2019，8万，主持
8. 四川大学专职博士后研发基金，2018.01-2019.12，15万，主持
9. 自然科学基金重大项目，81690261，332.6万元，2017.1-2021.12，参研
代表性研究论文
1. Qinglin Sheng, Ting Li, Xian Tang, Wei Zhao, Rong Guo, Xingli Cun, Shuya Zang, Zhirong Zhang, Man Li* and Qin He*. Comprehensively enhanced delivery cascade by transformable beaded nanofibrils for pancreatic cancer therapy. Nanoscale, 2021, 13, 13328.
2. Xiaoxiao Chen1, Yuan Tao1, Manmin He, Miao Deng, Rong Guo, Qinglin Sheng, Xuhui Wang, Kebai Ren, Ting Li, Xuan He, Shuya Zang, Zhirong Zhang, Man Li* and Qin He*. Co-delivery of autophagy inhibitor and gemcitabine using a pH-activatable core-shell nanobomb inhibits pancreatic cancer progression and metastasis. Theranostics 2021, 11, 18, 8692-8705.
3. Junyu Wu, Yang Long, Man Li*, Qin He*. Emerging nanomedicine-based therapeutics for hematogenous metastatic cascade inhibition: Interfering with the crosstalk between “seed and soil”. Acta Pharmaceutica Sinica B, 2021,11(8), 2286-2305.
4. Man Li, Mengmeng Li, Yiliang Yang, Yingke Liu, Hanbing Xie, Qianwen Yu, Lifeng Tian, Xian Tang, Kebai Ren, Jianping Li, Zhirong Zhang, Qin He*. Remodeling tumor immune microenvironment via targeted blockade of PI3K-γ and CSF-1/CSF-1R pathways in tumor associated macrophages for pancreatic cancer therapy. Journal of Controlled Release, 2020, 321, 23-35.
5. Xingli Cun, Jiantao Chen, Mengmeng Li, Xuan He, Xian Tang, Rong Guo, Miao Deng, Man Li*, Zhirong Zhang, Qin He*. Tumor-Associated Fibroblast-Targeted Regulation and Deep Tumor Delivery of Chemotherapeutic Drugs with a Multifunctional Size-Switchable Nanoparticle. ACS Applied Materials & Interfaces, 2019, 11, (43), 39545-39559.
6. Rong Guo,Yang Long, Zhengze Lu, Miao Deng, Penghui He, Man Li*, Qin He*. Enhanced stability and efficacy of GEM-TOS prodrug by co-assembly with antimetastatic shell LMWH-TOS. Acta Pharmaceutica Sinica B, 2020, 10, 10, 1977-1988.
7. Jiaojie Wei, Yang Long, Rong Guo, Xinlei Liu, Xian Tang, Jingdong Rao, Sheng Yin, Zhirong Zhang, Man Li*, Qin He. Multifunctional polymeric micelle-based chemo-immunotherapy with immune checkpoint blockade for efficient treatment of orthotopic and metastatic breast cancer. Acta Pharmaceutica Sinica B 2019; 9(4): 819–831.
8. Man Li, Hanbing Xie, Yingke Liu, Chunyu Xia, Xingli Cun, Yang Long, Xiaoxiao Chen, Miao Deng, Rong Guo, Zhirong Zhang, Qin He*. Knockdown of hypoxia-inducible factor-1 alpha by tumor targeted delivery of CRISPR/Cas9 system suppressed the metastasis of pancreatic cancer. Journal of Controlled Release, 2019, 304, 204-215.
9. Man Li, You Li, Ke Peng, Ying Wang, Tao Gong, Zhirong Zhang, Qin He, Xun Sun*. Engineering intranasal mRNA vaccines to enhance lymph node trafficking and immune responses. Acta Biomaterialia, 2017, 64, 237-248.
10. Man Li, Mengnan Zhao, Yao Fu, You Li, Tao Gong, Zhirong Zhang, Xun Sun. Enhanced intranasal delivery of mRNA vaccine by overcoming the nasal epithelial barrier via intra- and paracellular pathways. Journal of Controlled Release, 2016,228, 9-19.
