符垚教授
单位：四川大学华西药学院药剂学系
地址：成都市人民南路三段17号四川大学华西药学院 610041
Email: yfu4@scu.edu.cn
简历
2000 – 2004年四川大学华西药学院，理学学士
2004 – 2007年四川大学华西药学院，理学硕士，导师：张志荣教授
2007 – 2012年美国威斯康辛大学-麦迪逊分校药学院，PhD，导师：W. John Kao教授
2012 – 2014年美国威斯康辛大学-麦迪逊分校生物医学工程系，从事博士后研究
2014年3月– 2022年9月四川大学华西药学院药剂学系，特聘副研究员/副教授
2022年9月至今四川大学华西药学院药剂学系，教授博士生导师
主要研究方向：
靶向蛋白及细胞器降解技术、新型生物材料用于皮肤创口敷料、靶向和长效缓控药物递释的研究。在ACS Nano, Biomaterials, Acta Pharm Sin B, J. Control Rel等本领域权威杂志发表一作及通讯作者论文50余篇。申请并获授权美国发明专利1项；申请并获授权中国发明专利4项；参编英文专著2本；国家十四五规划教材《生物药剂学与药物代谢动力学》副主编（高等教育出版社），参编人民卫生出版社《药学英语》上下册及《学习指导》（第6版）。主持国家自然科学基金项目3项，参与国家自然科学基金重大项目1项，参与科技部重大研究计划1项。担任《亚洲药剂学杂志》、《沈阳药科大学学报》和Pharmaceutical Fronts青年编委。四川省第十三批学术和技术带头人后备人选。
近三年代表性文章
1. Xu YY, Gui JJ, Zhang YX, Nan SM, Che YJ, Cao X, Fang XJ, Gong T, Zhang ZR, Fu Y*. Targeting renal tubule epithelial cells via a dual functionalized oligosaccharide self-assembly in the management of acute and chronic kidney diseases. Acta Pharm Sin B, 2025. (In press)
2. Luo MQ#, Zhang YX#, He SWX, Guo YY, Cao X, Gong T, Zhang ZR, Deng L*, Fu Y*. Effervescent microneedles for codelivery of chitosan nanoparticles and indocyanine green to enhance treatment of diet-induced obesity in mice. ACS Nano, 2025, 19, 11792-11806. (# equal contribution)
3. Li YA, Wang JW, Yu RL, Gong T, Zhang ZR, Liu RH*, Fu Y*. Leveraging Chemotherapy-Induced PD-L1 Upregulation to Potentiate Targeted PD-L1 Degradation using Nanoparticle-Based Targeting Chimeras. Chemical Engineering Journal, 2024, 499, 155708.
4. Nan SM, Che YJ, Gong T, Zhang ZR, Fu Y*. Human serum albumin-enriched corona formation on chitosan oligosaccharide-derived micelles for efficient renal-targeted drug delivery to ameliorate acute kidney injury. ACS Appl Mater Interfaces, 2024, 16(37), 49913-49925.
5. Zhang YX, Luo MQ, Jia YX, Gao TT, Deng L, Gong T, Zhang ZR, Cao X*, Fu Y*. Adipocyte-targeted delivery of rosiglitazone with localized photothermal therapy for the treatment of diet-induced obesity in mice. Acta Biomater. 2024, 181, 317-332.
6. Gui JJ, Zhu YT, Chen X, Gong T, Zhang ZR, Yu RL*, Fu Y*. Systemic platelet inhibition with localized chemotherapy by an injectable ROS-scavenging gel against postsurgical breast cancer recurrence and metastasis. Acta Biomater. 2024, 177, 388-399.
7. Chen X, Ouyang HL, Zhang YX, Chen CL, Gong T, Zhang ZR, Liu RH*, Fu Y*. Antigen-specific T cell Activation through Targeted Delivery of In-Situ Generated Antigen and Calcium Ionophore to enhance antitumor immunotherapy. J Control Rel. 2024, 365, 544-557.
8. Gengji JJ, Gong T, Zhang ZR, Deng L*,Fu Y*. Imaging techniques for studying solid dosage formulation: principles and applications.J Control Rel. 2023, 361, 659-670.
9. Li CR, Wang JR, Niu YN, Zhang HN, Ouyang HL, Zhang GW,Fu Y*. Baicalin nanocomplexes with an in situ-forming biomimetic gel implant for repair of calvarial bone defects via localized sclerostin inhibition.ACS Appl Mater Interfaces.2023, 15(7)), 9044-9057.
10. Wang M#, Wang YJ#,Gong T, Zhang ZR,Fu Y*. TLR4 blockade using docosahexaenoic acid restores vulnerability of drug-tolerant tumor cells and prevents breast cancer metastasis and post-surgical relapse.ACS Bio & Med Chem Au. 2023, 3, 97-113.(#co-first authors)
书稿章节
Fu Y.“Co-delivery of anticancer therapeutics via lipid-based nanoscale delivery systems” Chapter in: Marlene Lúcio, Carla M. Lopes, Maria Elisabete C.D. Real Oliveira “Functional Lipid Nanosystems in Cancer”. Pan Stanford Publishing and CRC Press. 2022.
Fu Y, Kao WJ. Proteomic approaches to characterize surface-bound proteins and material-mediated cellular proteins. Proteins at Interfaces III: State of the Art Book series: ACS Symposium Series. Editors: T Horbett, J Brash, W Norde. 2012,1120,809-837.
Yao Fu PhD
ACADEMIC QUALIFICATIONS
Ph.D.University of Wisconsin-Madison 2007 - 2012
May 2012 Pharmaceutical Sciences Advisor: Dr. W. John Kao
M.S.Sichuan University 2004 - 2007
July 2007 Pharmaceutical Sciences Advisor: Dr. Zhirong Zhang
B.S.Sichuan University 2000 – 2004
July 2004 Pharmacy
PREVIOUS ACADEMIC POSITIONS HELD
Postdoctoral Research Associate, 9/2012 – 3/2014, Department of Biomedical Engineering (Co-advised by Dr. Pamela Kreeger and Dr. Kristyn Masters), University of Wisconsin-Madison
PRESENT ACADEMIC POSITIONS HELD
Associate Professor, 3/2014 – 9/2022, West China School of Pharmacy, Sichuan University
Professor, 9/2022 – now, West China School of Pharmacy, Sichuan University
