鲜苗 特聘副研究员
单位：四川大学华西药学院药理系
通讯地址：成都市人民南路三段17号四川大学华西药学院（邮编610041）
电子邮箱：miaoxian@scu.edu.cn
教育工作经历：
2025 - 今，四川大学，华西药学院，特聘副研究员
2019 - 2024，康奈尔大学医学院-Houston Methodist Hospital，博士后研究员
2014 - 2019，浙江大学，药学院，药理学，硕博连读，博士
2010 - 2014，浙江大学，药学院，药学，学士
研究方向：肿瘤药理学、抗肿瘤靶点的发现及机制研究等；天然产物及衍生物的活性筛选及作用机制研究。
发表论文：
1) Xian, M.#, Wang, Q.#, Xiao, L., Zhong, L., Xiong, W., Ye, L., ... & Yi, Q. (2024). Leukocyte immunoglobulin-like receptor B1 (LILRB1) protects human multiple myeloma cells from ferroptosis by maintaining cholesterol homeostasis. Nature Communications, 15, 5767 (2024). https://doi.org/10.1038/s41467-024-50073-x
2) Chen, Y.#, Xian, M.#, Ying, W., Bing, S., Liu, J., Xiang, S., …&Ying, M. (2024). Succinate dehydrogenase deficiency-driven succinate accumulation induces drug resistance in acute myeloid leukemia via ubiquitin-cullin regulation. Nature Communications, 15, 9820 (2024). https://doi.org/10.1038/s41467-024-53398-9
3) Xiao, L.#, Xian, M.#, Zhang, C., Guo, Q., & Yi, Q. (2024). Lipid peroxidation of immune cells in cancer. Frontiers in Immunology, 14, 1322746.
4) Xian, M.#, Cao, H.#, Cao, J., Shao, X., Zhu, D., Zhang, N., ... & He, Q. (2017). Bortezomib sensitizes human osteosarcoma cells to adriamycin-induced apoptosis through ROS-dependent activation of p-eIF2α/ATF4/CHOP axis. International journal of cancer,141(5), 1029-1041.
5) Zhou, Q.#, Xian, M.#, Xiang, S., Xiang, D., Shao, X., Wang, J., ... & He, Q. (2017). All-trans retinoic acid prevents osteosarcoma metastasis by inhibiting M2 polarization of tumor-associated macrophages. Cancer immunology research, 5(7), 547-559.
6) Xiao, L., Duan, R., Liu, W., Zhang, C., Ma, X., Xian, M., ... & Yi, Q. (2025). Adoptively transferred tumor-specific IL-9-producing cytotoxic CD8+ T cells activate host CD4+ T cells to control tumors with antigen loss. Nature Cancer, 1-18.
7) Xiong, W., Xiao, L., Duan, R., Wang, Q., Xian, M., Zhang, C., ... & Yi, Q. (2025). Depletion of myeloid-derived suppressor cells sensitizes murine multiple myeloma to PD-1 checkpoint inhibitors. Journal for Immunotherapy of Cancer, 13(1), e008979.
8) Qian, J., Wang, Q., Xiao, L., Xiong, W., Xian, M., Su, P., ... & Yi, Q. (2024). Development of therapeutic monoclonal antibodies against DKK1 peptide-HLA-A2 complex to treat human cancers. Journal for Immunotherapy of Cancer, 12(1).
9) Xiao, L., Ma, X., Ye, L., Su, P., Xiong, W., Bi, E., Wang, Q., Xian, M., ... & Yi, Q. (2022). IL-9/STAT3/fatty acid oxidation–mediated lipid peroxidation contributes to Tc9 cell longevity and enhanced antitumor activity. The Journal of clinical investigation, 132(7).
10) Su, P., Xiao, L., Ye, L., Wang, Z., Xiong, W., Wang, Q., Ma, X., Xian, M., ... & Yi, Q. (2022). A novel role of lysophosphatidic acid (LPA) in human myeloma resistance to proteasome inhibitors. Journal of hematology & oncology, 15(1), 1-6.
11) Wang, Q., Lin, Z., Wang, Z., Ye, L., Xian, M., Xiao, L., ... & Yi, Q. (2021). RARγ activation sensitizes human myeloma cells to carfilzomib treatment through OAS-RNase L innate immune pathway. Blood, 139(1), 59-72.139(1), 59-72.
12) Wang, Q., Zhao, D., Xian, M., Wang, Z., Bi, E., Su, P., ... & Yi, Q. (2020). MIF as a biomarker and therapeutic target for overcoming resistance to proteasome inhibitors in human myeloma. Blood, 136(22), 2557-2573.
13) Li, Y., Xian, M., Yang, B., Ying, M., & He, Q. (2017). Inhibition of KLF4 by statins reverses adriamycin-induced metastasis and cancer stemness in osteosarcoma cells. Stem cell reports, 8(6), 1617-1629.
14) Zhang, N., Xie, T., Xian, M., Wang, Y., Li, H., Ying, M., & Ye, Z. (2016). SIRT1 promotes metastasis of human osteosarcoma cells. Oncotarget, 7(48), 79654-79669.
15) Shao, X., Liu, Y., Li, Y., Xian, M., Zhou, Q., Yang, B., ... & He, Q. (2016). The HER2 inhibitor TAK165 sensitizes human acute myeloid leukemia cells to retinoic acid-induced myeloid differentiation by activating MEK/ERK mediated RARα/STAT1 axis. Scientific reports, 6(1), 1-11.
